Phospho-STAT6 (Tyr641) Recombinant Rabbit Monoclonal Antibody (46H1L12)

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-STAT6 (Tyr641) Recombinant Rabbit Monoclonal Antibody (46H1L12)

catalog :

700247

quantity :

100 µg

price :

US 425.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

46H1L12

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 3

Reference
Ghonim M, Wang J, Ibba S, Luu H, Pyakurel K, Benslimane I, et al. Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway. J Transl Med. 2018;16:243 pubmed publisher
Seamons A, Treuting P, Meeker S, Hsu C, Paik J, Brabb T, et al. Obstructive Lymphangitis Precedes Colitis in Murine Norovirus-Infected Stat1-Deficient Mice. Am J Pathol. 2018;188:1536-1554 pubmed publisher
Botbol Y, Patel B, Macian F. Common Î³-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation. Autophagy. 2015;11:1864-77 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-STAT6 (Tyr641) Recombinant Rabbit Monoclonal Antibody (46H1L12)

Catalog # :

700247

Quantity :

100 µg

Price :

US 425.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

ChIP assay: 3 µg, ELISA: 1-5 µg/mL, Immunocytochemistry: 2-4 µg, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 0.5-1 µg/mL

Species :

Human, Mouse

Clone :

46H1L12

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.

Immunogen :

A peptide corresponding to amino acids 636-645 of P42226.

Format :

Liquid

Applications w/Dilutions :

ChIP assay: 3 µg, ELISA: 1-5 µg/mL, Immunocytochemistry: 2-4 µg, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 0.5-1 µg/mL

Aliases :

12S1644; D12S1644; IL4 STAT; IL-4 Stat; IL-4-STAT; signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; signal transducer and transcription activator 6; STAT; STAT, interleukin4-induced; Stat6; STAT-6; STAT6B; STAT6C; transcription factor IL-4 STAT

more info or order :

Invitrogen product webpage