MARVELD2 Recombinant Rabbit Monoclonal Antibody (54H19L38) | Invitrogen 700191 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MARVELD2 Recombinant Rabbit Monoclonal Antibody (54H19L38)

catalog :

700191

quantity :

100µg

price :

US 345

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

54H19L38

reactivity :

human, dogs

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; dogs; 1:1000; fig 3a	Ronaghan N, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, et al. The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction. Am J Physiol Gastrointest Liver Physiol. 2016;311:G466-79 pubmed publisher
immunocytochemistry; dogs western blot; dogs	Shiobara T, Usui T, Han J, Isoda H, Nagumo Y. The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin. PLoS ONE. 2013;8:e79954 pubmed publisher
	Jennek S, Mittag S, Reiche J, Westphal J, Seelk S, DÃ¶rfel M, et al. Tricellulin is a target of the ubiquitin ligase Itch. Ann N Y Acad Sci. 2017;1397:157-168 pubmed publisher
	Czulkies B, Mastroianni J, Lutz L, Lang S, Schwan C, Schmidt G, et al. Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells. Oncotarget. 2017;8:37009-37022 pubmed publisher
	Li C, Ma H, Wang Y, Cao Z, Graves Deal R, Powell A, et al. Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. J Clin Invest. 2014;124:2172-87 pubmed
	Richter J, Pieper R, Zakrzewski S, Gunzel D, Schulzke J, Van Kessel A. Diets high in fermentable protein and fibre alter tight junction protein composition with minor effects on barrier function in piglet colon. Br J Nutr. 2014;111:1040-9 pubmed publisher
	Mariano C, Palmela I, Pereira P, Fernandes A, Falcão A, Cardoso F, et al. Tricellulin expression in brain endothelial and neural cells. Cell Tissue Res. 2013;351:397-407 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MARVELD2 Recombinant Rabbit Monoclonal Antibody (54H19L38)

Catalog # :

700191

Quantity :

100µg

Price :

US 345

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 1-3 µg/mL

Species :

Human

Clone :

54H19L38

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Tight junctions form an important barrier of paracellular transport in epithelial cells. Sealing of two adjacent cells at bicellular tight junctions, a point where three adjacent cells are in contact with each other. Tricellulin is the first protein identified that specifically concentrates in tricellular tight junctions. This protein has four membrane spanning domains, similarly to claudins. Tricellulin expression is high in epithelium-derived tissues, such as small intestine, kidney and lung. Functional evidence for the role of tricellulin in tight junction formation comes from siRNA studies, where suppression of its expression leads to compromised epithelial barrier and tight junction formation. Loss of function in tricellulin mutants missing all or most of a conserved region in the cytosolic domain which binds to the cytosolic scaffolding protein ZO-1, indicate that interaction with other known tight junction proteins plays an important role for the function of tricellulin.

Immunogen :

A recombinant protein corresponding to amino acids 369-558 of Q8N4S9.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 1-3 µg/mL

Aliases :

BC003296; DFNB49; MARVD2; MARVEL (membrane-associating) domain containing 2; MARVEL domain containing 2; MARVEL domain-containing protein 2; MARVELD2; Mrvldc2; TRIC; Trica; Tricb; Tricc; Tricellulin

more info or order :

Invitrogen product webpage