product summary
Loading...
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PYK2 Recombinant Rabbit Monoclonal Antibody (9H12L1)
catalog :
700183
quantity :
100 µg
price :
US 514
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
9H12L1
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig s1a
Chan G, White C, Winn P, Cimpean M, Replogle J, Glick L, et al. CD33 modulates TREM2: convergence of Alzheimer loci. Nat Neurosci. 2015;18:1556-8 pubmed publisher
Al Juboori S, Vadakekolathu J, Idri S, Wagner S, Zafeiris D, Pearson J, et al. PYK2 promotes HER2-positive breast cancer invasion. J Exp Clin Cancer Res. 2019;38:210 pubmed publisher
product information
Product Type :
Antibody
Product Name :
PYK2 Recombinant Rabbit Monoclonal Antibody (9H12L1)
Catalog # :
700183
Quantity :
100 µg
Price :
US 514
Clonality :
Recombinant Monoclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Human
Applications :
ChIP Assay: 1 µL, Flow Cytometry: 2-4 µg/1x10^6 cells, Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 4-6 µg/mL, Western Blot: 1-3 µg/mL
Species :
Human
Clone :
9H12L1
Isotype :
IgG
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
Immunogen :
A recombinant protein corresponding to amino acids 780-880 of Q14289.
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: 1 µL, Flow Cytometry: 2-4 µg/1x10^6 cells, Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 4-6 µg/mL, Western Blot: 1-3 µg/mL
Aliases :
CADTK; CAK beta; CAKB; CAKbeta; CAK-beta; calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; cellular adhesion kinase beta; E430023O05Rik; FADK; FADK 2; FADK2; FAK; FAK1; FAK2; focal adhesion kinase 2; FRNK; PKB; pp125FAK; proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; PTK; PTK2 protein tyrosine kinase 2 beta; PTK2B; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; related adhesion focal tyrosine kinase
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA