Claudin 18 Recombinant Rabbit Monoclonal Antibody (34H14L15)

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Claudin 18 Recombinant Rabbit Monoclonal Antibody (34H14L15)

catalog :

700178

quantity :

100 µg

price :

US 375.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

34H14L15

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:200; loading ...; fig 4b	Lee Thacker S, Jeon H, Choi Y, Taniuchi I, Takarada T, Yoneda Y, et al. Core Binding Factors are essential for ovulation, luteinization, and female fertility in mice. Sci Rep. 2020;10:9921 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:250; loading ...; fig 7c	Quilichini E, Fabre M, Dirami T, Stedman A, De Vas M, Ozguc O, et al. Pancreatic ductal deletion of Hnf1b disrupts exocrine homeostasis, leads to pancreatitis and facilitates tumorigenesis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:2000; fig 2	Krah N, De La O J, Swift G, Hoang C, Willet S, Chen Pan F, et al. The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma. elife. 2015;4: pubmed publisher
western blot; rat	Overgaard C, Schlingmann B, Dorsainvil White S, Ward C, Fan X, Swarnakar S, et al. The relative balance of GM-CSF and TGF-Î²1 regulates lung epithelial barrier function. Am J Physiol Lung Cell Mol Physiol. 2015;308:L1212-23 pubmed publisher
immunohistochemistry; rat	Ward C, Schlingmann B, Stecenko A, Guidot D, Koval M. NF-ÎºB inhibitors impair lung epithelial tight junctions in the absence of inflammation. Tissue Barriers. 2015;3:e982424 pubmed publisher
immunohistochemistry - paraffin section; human; 1:300	Capella C, Marando A, Longhi E, Bernasconi B, Finzi G, Parravicini C, et al. Primary gastric Merkel cell carcinoma harboring DNA polyomavirus: first description of an unusual high-grade neuroendocrine carcinoma. Hum Pathol. 2014;45:1310-4 pubmed publisher
immunohistochemistry; human; 1:1000	Jang B, Lee B, Kim W. Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis. PLoS ONE. 2013;8:e82390 pubmed publisher
immunohistochemistry - paraffin section; human	Dainese E, Cimetti L, Capella C, Riva C. Linear and micronodular neuroendocrine cell hyperplasia in an ovarian mucinous cystadenoma. Pathol Res Pract. 2013;209:670-3 pubmed publisher
	Weber B, Mendler M, Lackner I, von Zelewski A, Höfler S, Baur M, et al. Lung injury after asphyxia and hemorrhagic shock in newborn piglets: Analysis of structural and inflammatory changes. PLoS ONE. 2019;14:e0219211 pubmed publisher
	Coati I, Lotz G, Fanelli G, Brignola S, Lanza C, Cappellesso R, et al. Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases. Br J Cancer. 2019;: pubmed publisher
	Chen H, Lu R, Zhang Y, Sun J. Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs. Tissue Barriers. 2018;6:1-13 pubmed publisher
	Luo J, Chimge N, Zhou B, Flodby P, Castaldi A, Firth A, et al. CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018;143:3169-3180 pubmed publisher
	Zhou B, Flodby P, Luo J, Castillo D, Liu Y, Yu F, et al. Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018;128:970-984 pubmed publisher
	Zhang Y, Yan W, Mathew E, Bednar F, Wan S, Collins M, et al. CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice. Cancer Immunol Res. 2014;2:423-35 pubmed publisher
	Zhang Y, Yan W, Collins M, Bednar F, Rakshit S, Zetter B, et al. Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. Cancer Res. 2013;73:6359-74 pubmed publisher
	Collins M, Bednar F, Zhang Y, Brisset J, Galban S, Galban C, et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest. 2012;122:639-53 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Claudin 18 Recombinant Rabbit Monoclonal Antibody (34H14L15)

Catalog # :

700178

Quantity :

100 µg

Price :

US 375.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunohistochemistry: 2-4 µg/mL, Western Blot: 2-3 µg/mL

Species :

Human, Mouse, Rat

Clone :

34H14L15

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear.

Immunogen :

A peptide corresponding to amino acids 224-237 of P56856.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunohistochemistry: 2-4 µg/mL, Western Blot: 2-3 µg/mL

Aliases :

claudin 18; claudin 18-like; claudin-18; CLDN18; SFTA5; SFTPJ; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J; UNQ778/PRO1572

more info or order :

Invitrogen product webpage