TRAF3 Recombinant Rabbit Monoclonal Antibody (12H13L59) | Invitrogen 700121 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TRAF3 Recombinant Rabbit Monoclonal Antibody (12H13L59)

catalog :

700121

quantity :

100 ug

price :

US 493.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

12H13L59

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 3

Reference
Lim M, Maubach G, Birkl Toeglhofer A, Haybaeck J, Vieth M, Naumann M. A20 undermines alternative NF-κB activity and expression of anti-apoptotic genes in Helicobacter pylori infection. Cell Mol Life Sci. 2022;79:102 pubmed publisher
Maubach G, Lim M, Sokolova O, Backert S, Meyer T, Naumann M. TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-κB pathways. EMBO Rep. 2021;22:e52878 pubmed publisher
Varfolomeev E, Goncharov T, Maecker H, Zobel K, Komuves L, Deshayes K, et al. Cellular inhibitors of apoptosis are global regulators of NF-?B and MAPK activation by members of the TNF family of receptors. Sci Signal. 2012;5:ra22 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TRAF3 Recombinant Rabbit Monoclonal Antibody (12H13L59)

Catalog # :

700121

Quantity :

100 ug

Price :

US 493.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1-3 ug/mL

Species :

Human

Clone :

12H13L59

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e. g. RANK, CD30, CD40, etc. ) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region of similarity to the tumor necrosis factor-alpha (TNF-alpha) receptor-associated factors. TRAF3 binds only a single site, which contains the sequence PEQET, whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain.

Immunogen :

A recombinant protein corresponding to amino acids 1-187 of Q13114.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1-3 ug/mL

Aliases :

AI528849; amn; CAP1; CAP-1; CD40 associated protein 1; CD40 binding protein; CD40 receptor associated factor 1; CD40 receptor-associated factor 1; CD40-binding protein; CD40BP; CRAF1; IIAE5; LAP1; LMP1-associated protein 1; RING-type E3 ubiquitin transferase TRAF3; T-BAM; TNF receptor associated factor 3; Tnf receptor-associated factor 3; TRAF3; Trafamn