TAK1 Recombinant Rabbit Monoclonal Antibody (28H25L68) | Invitrogen 700113 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TAK1 Recombinant Rabbit Monoclonal Antibody (28H25L68)

catalog :

700113

quantity :

100 ug

price :

US 450.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

28H25L68

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry

citations: 1

Reference
Athie A, Marchese F, González J, Lozano T, Raimondi I, Juvvuna P, et al. Analysis of copy number alterations reveals the lncRNA ALAL-1 as a regulator of lung cancer immune evasion. J Cell Biol. 2020;219: pubmed publisher

product information

Product Type :

Antibody

Product Name :

TAK1 Recombinant Rabbit Monoclonal Antibody (28H25L68)

Catalog # :

700113

Quantity :

100 ug

Price :

US 450.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 3-5 ug/1x10^6 cells, Immunocytochemistry: 2-3 ug/mL, Western Blot: 0.5-2 ug/mL

Species :

Human, Mouse, Rat

Clone :

28H25L68

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

TAK1 (also known as MAP3K7), a part of the serine/threonine kinase family, is a versatile protein with many signaling functions. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin beta1 and integrin beta5, promoting proper wound healing. TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 is autophosphorylated at Thr178, Thr184, Thr187 and Ser192, and finally TAK1 phosphorylates IKK- beta. Additionally, TAK1 represses human telomerase reverse transcriptase suggesting a role in regulation of cell lifespan.

Immunogen :

A recombinant protein corresponding to amino acids 476-606 of O43318.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 3-5 ug/1x10^6 cells, Immunocytochemistry: 2-3 ug/mL, Western Blot: 0.5-2 ug/mL

Aliases :

B430101B05; C87327; hypothetical protein LOC553788; I79_000697; M3K7; map3k7; map3k7.L; MAPKKK; MEKK7; mitogen activated protein kinase kinase kinase 7; mitogen-activated protein kinase kinase kinase 7; mitogen-activated protein kinase kinase kinase 7 L homeolog; RP1-154G14.1; si:ch211-225h9.1; Tak1; TAK1z; TGF1a; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; TGF-beta-activated kinase TAK1; transforming growth factor beta-activated kinase 1; transforming growth factor-beta-activated kinase 1; XELAEV_18027270mg; xTAK1; zgc:110612