T-bet Recombinant Rabbit Monoclonal Antibody (16H4L5) | Invitrogen 700059 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

T-bet Recombinant Rabbit Monoclonal Antibody (16H4L5)

catalog :

700059

quantity :

100 ug

price :

US 450.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

16H4L5

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 2

Reference
Walusimbi S, Pate J. Luteal cells from functional and regressing bovine corpora lutea differentially alter the function of gamma delta T cells. Biol Reprod. 2014;90:140 pubmed publisher
Mosenson J, Zloza A, Nieland J, Garrett Mayer E, Eby J, Huelsmann E, et al. Mutant HSP70 reverses autoimmune depigmentation in vitiligo. Sci Transl Med. 2013;5:174ra28 pubmed publisher

product information

Product Type :

Antibody

Product Name :

T-bet Recombinant Rabbit Monoclonal Antibody (16H4L5)

Catalog # :

700059

Quantity :

100 ug

Price :

US 450.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 8-12 ug/mL, Immunohistochemistry (Paraffin): 4-6 ug/mL, Western Blot: 5-7 ug/mL

Species :

Human

Clone :

16H4L5

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.

Immunogen :

A peptide corresponding to amino acids 520-535 of Q9UL17.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 8-12 ug/mL, Immunohistochemistry (Paraffin): 4-6 ug/mL, Western Blot: 5-7 ug/mL

Aliases :

HGNC:11599; LOW QUALITY PROTEIN: T-box transcription factor TBX21; Tbet; T-bet; TBLYM; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; TBT1; TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; transcription factor TBLYM; transcription factor T-box 21