Phospho-PKC theta (Thr538) Recombinant Rabbit Monoclonal Antibody (F4H4L1)

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-PKC theta (Thr538) Recombinant Rabbit Monoclonal Antibody (F4H4L1)

catalog :

700043

quantity :

100 µg

price :

US 425.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

F4H4L1

reactivity :

human, mouse

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 5a	Ozay E, González Pérez G, Torres J, Vijayaraghavan J, Lawlor R, Sherman H, et al. Intracellular Delivery of Anti-pPKC? (Thr538) via Protein Transduction Domain Mimics for Immunomodulation. Mol Ther. 2016;24:2118-2130 pubmed publisher
immunohistochemistry - paraffin section; mouse; fig 5	Li Z, Abdullah C, Jin Z. Inhibition of PKC-? preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy. Br J Pharmacol. 2014;171:2913-24 pubmed publisher
	Wartewig T, Kurgyis Z, Keppler S, Pechloff K, Hameister E, Ollinger R, et al. PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis. Nature. 2017;552:121-125 pubmed publisher
	von Essen M, Kongsbak M, Levring T, Hansen A, Boding L, Lauritsen J, et al. PKC-? exists in an oxidized inactive form in naive human T cells. Eur J Immunol. 2013;43:1659-66 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-PKC theta (Thr538) Recombinant Rabbit Monoclonal Antibody (F4H4L1)

Catalog # :

700043

Quantity :

100 µg

Price :

US 425.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1:100-1:500, Immunohistochemistry (Paraffin): 4-6 µg/mL, Western Blot: 2-4 µg/mL

Species :

Human

Clone :

F4H4L1

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Protein Kinase C (PKC) isoforms are serine/threonine kinases involved in signal transduction pathways that govern a wide range of physiological processes including differentiation, proliferation, gene expression, brain function, membrane transport and the organization of cytoskeletal and extracellular matrix proteins. Increasing evidence from studies using in vitro and in vivo systems points to PKC as a key regulator of critical cell cycle transitions, including cell cycle entry and exit and the G1 and G2 checkpoints. PKC-mediated control of these transitions can be negative or positive, depending on the timing of PKC activation during the cell cycle and on the specific PKC isozymes involve. There have been at least 12 different PKC isoforms identified in humans to date, including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. The different PKC isoforms vary in structure, subcellular localization, tissue distribution and response to extracellular signals. PKC beta II has been shown to be expressed, in part, in cardiac muscle, intestinal epithelium, kidney and pancreas. PKC beta II has been shown to be involved in cell cycle progression and cancer proliferation.

Immunogen :

A peptide corresponding to amino acids 531-539 of Q04759.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:100-1:500, Immunohistochemistry (Paraffin): 4-6 µg/mL, Western Blot: 2-4 µg/mL

Aliases :

A130035A12Rik; AW494342; EC 2.7.11.13; kinase nPKC-theta; KPCT; MGC126514; MGC141919; nPKC-theta; PKC theta; PKC-0; Pkcq; PKCtheta; PKC-theta; PRKCQ; PRKCT; protein kinase C theta; protein kinase C theta type; protein kinase C, theta; RP11-563J2.1; si:ch211-239o15.1

more info or order :

Invitrogen product webpage