Phospho-JAK1 (Tyr1022, Tyr1023) Recombinant Rabbit Monoclonal Antibody (59H4L5)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-JAK1 (Tyr1022, Tyr1023) Recombinant Rabbit Monoclonal Antibody (59H4L5)

catalog :

700028

quantity :

100 ug

price :

US 450.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

59H4L5

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 2

Reference
Sayed R, Ghazy A, Yammany M. Recombinant human erythropoietin and interferon-β-1b protect against 3-nitropropionic acid-induced neurotoxicity in rats: possible role of JAK/STAT signaling pathway. Inflammopharmacology. 2022;30:667-681 pubmed publisher
Oetjen L, Mack M, Feng J, Whelan T, Niu H, Guo C, et al. Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. Cell. 2017;171:217-228.e13 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-JAK1 (Tyr1022, Tyr1023) Recombinant Rabbit Monoclonal Antibody (59H4L5)

Catalog # :

700028

Quantity :

100 ug

Price :

US 450.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

ChIP Assay: 1 uL, Immunocytochemistry: 1:100-1:500, Western Blot: 0.5-2 ug/mL

Species :

Human, Mouse

Clone :

59H4L5

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.

Immunogen :

A peptide corresponding to amino acids 1030-1039 of P23458. This site is commonly referred to as pY1022/pY1023 in the literature.

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1 uL, Immunocytochemistry: 1:100-1:500, Western Blot: 0.5-2 ug/mL

Aliases :

AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1