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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IRAK4 Recombinant Rabbit Monoclonal Antibody (12H2L6)
catalog :
700026
quantity :
100 µg
price :
US 375.00
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
12H2L6
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
product information
Product Type :
Antibody
Product Name :
IRAK4 Recombinant Rabbit Monoclonal Antibody (12H2L6)
Catalog # :
700026
Quantity :
100 µg
Price :
US 375.00
Clonality :
Recombinant Monoclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Human
Applications :
ChIP assay: 1 µL, Immunocytochemistry: 4-6 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 2-3 µg/mL
Species :
Human
Clone :
12H2L6
Isotype :
IgG
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kappa-B and MAP kinase (MAPK) by IL-1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
Immunogen :
A peptide corresponding to amino acids 41-52 of Q9NWZ3.
Format :
Liquid
Applications w/Dilutions :
ChIP assay: 1 µL, Immunocytochemistry: 4-6 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 2-3 µg/mL
Aliases :
8430405M07Rik; 9330209D03Rik; interleukin 1 receptor associated kinase 4; interleukin-1; interleukin-1 receptor-associated kinase 4; IPD1; Irak4; IRAK-4; NY-REN-64; REN64; renal carcinoma antigen NY-REN-64
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA