Phospho-ERK1/ERK2 (Thr185, Tyr187) Recombinant Rabbit Monoclonal Antibody (15H10L7)

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-ERK1/ERK2 (Thr185, Tyr187) Recombinant Rabbit Monoclonal Antibody (15H10L7)

catalog :

700012

quantity :

100 ug

price :

US 552.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

15H10L7

reactivity :

human, mouse, rat, dogs

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
western blot; rat; loading ...; fig 4a	Ahmad F, Salahuddin M, Alsamman K, Herzallah H, Al Otaibi S. Neonatal maternal deprivation impairs localized de novo activity-induced protein translation at the synapse in the rat hippocampus. Biosci Rep. 2018;38: pubmed publisher
western blot; human	Machado Neto J, Lazarini M, Favaro P, de Melo Campos P, Scopim Ribeiro R, Franchi Junior G, et al. ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. Biochim Biophys Acta. 2015;1853:583-93 pubmed publisher
western blot; mouse	Uitdehaag J, Sünnen C, van Doornmalen A, de Rouw N, Oubrie A, Azevedo R, et al. Multidimensional profiling of CSF1R screening hits and inhibitors: assessing cellular activity, target residence time, and selectivity in a higher throughput way. J Biomol Screen. 2011;16:1007-17 pubmed publisher
	Liu X, Jiang Y, Zhou H, Zhao X, Li M, Bao Z, et al. Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1. Cell Death Dis. 2023;14:118 pubmed publisher
	Pandya P, Kublo L, Stewart Ornstein J. p53 Promotes Cytokine Expression in Melanoma to Regulate Drug Resistance and Migration. Cells. 2022;11: pubmed publisher
	Messmann R, Dietl A, Wagner S, Domenig O, Jungbauer C, Luchner A, et al. Alterations of the renin angiotensin system in human end-stage heart failure before and after mechanical cardiac unloading by LVAD support. Mol Cell Biochem. 2020;472:79-94 pubmed publisher
	Sultana R, Shrestha A, Lee C, Ogundele O. Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression. Front Cell Neurosci. 2020;14:94 pubmed publisher
	Uka R, Britschgi C, Krättli A, Matter C, Mihic D, Okoniewski M, et al. Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth. Oncogene. 2020;39:4132-4154 pubmed publisher
	Pereira P, Ragupathi A, Shmuel S, Mandleywala K, Viola N, Lewis J. HER2-Targeted PET Imaging and Therapy of Hyaluronan-Masked HER2-Overexpressing Breast Cancer. Mol Pharm. 2020;17:327-337 pubmed publisher
	Bernardo P, Guimarães G, de Faria F, Longo G, Lopes G, Netto C, et al. LQB‑118 compound inhibits migration and induces cell death in glioblastoma cells. Oncol Rep. 2020;43:346-357 pubmed publisher
	Shrestha A, Sultana R, Lee C, Ogundele O. SK Channel Modulates Synaptic Plasticity by Tuning CaMKIIα/β Dynamics. Front Synaptic Neurosci. 2019;11:18 pubmed publisher
	Machado Neto J, Fenerich B, Scopim Ribeiro R, Eide C, Coelho Silva J, Dechandt C, et al. Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms. Cell Death Dis. 2018;9:311 pubmed publisher
	Yue J, Lai F, Beckedorff F, Zhang A, Pastori C, Shiekhattar R. Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs. Genes Dev. 2017;31:1809-1820 pubmed publisher
	Munjal C, Opoka A, Osinska H, James J, Bressan G, Hinton R. TGF-? mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease. Dis Model Mech. 2014;7:987-96 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-ERK1/ERK2 (Thr185, Tyr187) Recombinant Rabbit Monoclonal Antibody (15H10L7)

Catalog # :

700012

Quantity :

100 ug

Price :

US 552.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Canine, Human, Rat

Applications :

ChIP Assay: 1 uL, ELISA: Assay-dependent, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 1 ug/mL

Species :

Canine, Human, Rat

Clone :

15H10L7

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase (ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1.

Immunogen :

A peptide corresponding to amino acids 198-208 and 181-191 of P27361 and P28482, respectively.

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1 uL, ELISA: Assay-dependent, Immunocytochemistry: 5 ug/mL, Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 1 ug/mL

Aliases :

12559; 9030612K14Rik; AA407128; AU018647; BcDNA:RE08694; C78273; CG12559; CG12559-PA; CG12559-PC; CG12559-PD; CG12559-PE; CG12559-PG; CG12559-PH; CG12559-PI; CG18732; CT34260; CT39192; DERK; D-ERK; DERK-A; Diphospho-ERK; dm-dpERK; Dmel CG12559; Dmel_CG12559; DmErk; DmERKA; DmERK-A; DmMAPK; dpERK; dp-ERK; dpERK1; dpMAPK; drosophila ERK; Dsor2; E(sina)7; EC2-1; EK2-1; enhancer of seven in absentia 7; ERK; Erk MAP kinase; Erk/Map kinase; ERK/rolled; Erk1; Erk-1; erk1 erk2; Erk1/2; ERK1b; ERK2; ERK-2; ERKA; ERK-A; ERT1; ERT2; Esrk1; extracellular signal-regulated kinase; extracellular signal-regulated kinase (ERK2); extracellular signal-regulated kinase 1; Extracellular signal-regulated kinase 2; extracellular signal-regulated kinase A; extracellular signal-regulated kinase-1; extracellular signal-regulated kinase-2; extracellular signal-related kinase 1; Extracellular-regulated kinase A; extracellular-signal-regulated kinase 2; Extracellular-signal-related kinase A; EY2-2; fi06b09; GroupII; HS44KDAP; HUMKER1A; I79_009500; I79_018350; insulin-stimulated MAP2 kinase; l(2)41Ac; l(2R)EMS45-39; M phase MAP kinase; MAP kinase; MAP kinase 1; MAP kinase 2; MAP kinase 3; MAP kinase isoform p42; MAP kinase isoform p44; MapK; MAP-k; MAPK 1; MAPK 2; MAPK 3; MAPK1; mapk1.S; mapk1a; mapk1-a; mapk1-b; mapk2; mapk3; MAP-kinase; MBP kinase; Microtubule-associated protein 2 kinase; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen-activated 3; mitogen-activated protein kinase; mitogen-activated protein kinase 1; mitogen-activated protein kinase 1 S homeolog; mitogen-activated protein kinase 1a; mitogen-activated protein kinase 2; Mitogen-activated protein kinase 3; Mitogen-activated protein kinase ERK-A; MNK1; mpk1; Mtap2k; Myelin basic protein kinase; Myelin xP42 protein kinase; p38; p40; p41; p41mapk; p42; p42 MAP Kinase; P42MAPK; p42-MAPK; p44; p44 MAP kinase; p44erk1; p44-ERK1; p44mapk; p44-MAPK; pERK; p-ERK; phospho-ERK; pMapK; pp42/MAP kinase; Prkm1; PRKM2; Prkm3; protein kinase; Protein rolled; protein tyrosine kinase ERK2; RE08694p; RL; rl/ERK; rl/MAPK; rll; rl-PA; rl-PC; rl-PD; rl-PE; rl-PG; rl-PH; rl-PI; roll; rolled; sem; sevenmaker; SR2-1; Su(Raf)2B; wu:fi06b09; XELAEV_18010534mg; xp42; zERK1; zERK2

more info or order :

Invitrogen product webpage