CD11b Monoclonal Antibody (ICRF44), Super Bright 702, eBioscience™ | Invitrogen 67-0118-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD11b Monoclonal Antibody (ICRF44), Super Bright 702, eBioscience™

catalog :

67-0118-41

quantity :

25Tests

price :

US 163

clonality :

monoclonal

host :

mouse

conjugate :

Super Bright 702

clone name :

ICRF44

reactivity :

crab eating macaque, human, chimpanzee

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

CD11b Monoclonal Antibody (ICRF44), Super Bright 702, eBioscience™

Catalog # :

67-0118-41

Quantity :

25Tests

Price :

US 163

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Baboon, Chimpanzee, Cynomolgus Monkey, Human, Rhesus Monkey

Applications :

Flow Cytometry: 5 µL (0.125 µg)/test

Species :

Baboon, Chimpanzee, Cynomolgus Monkey, Human, Rhesus Monkey

Clone :

ICRF44

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.125 µg)/test

Aliases :

HCD11B