This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD326 (EpCAM) Monoclonal Antibody (G8.8), Super Bright 645, eBioscience
catalog :
64-5791-82
quantity :
100 ug
price :
US 394.00
clonality :
monoclonal
host :
rat
conjugate :
Super Bright 645
clone name :
G8.8

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 34
Reference
Zanini F, Che X, Suresh N, Knutsen C, Klavina P, Xie Y, et al. Hyperoxia prevents the dynamic neonatal increases in lung mesenchymal cell diversity. Sci Rep. 2024;14:2033 pubmed publisher
Major J, Crotta S, Finsterbusch K, Chakravarty P, Shah K, Frederico B, et al. Endothelial AHR activity prevents lung barrier disruption in viral infection. Nature. 2023;621:813-820 pubmed publisher
Dowbaj A, Kohler T, Cordero Espinoza L, Hollfelder F, Huch M. Generation of liver mesenchyme and ductal cell organoid co-culture using cell self-aggregation and droplet microfluidics. STAR Protoc. 2023;4:102333 pubmed publisher
Lee J, Kim S, Lee B, Kim Y, Kim K, Chung G, et al. Major depression-related factor NEGR1 controls salivary secretion in mouse submandibular glands. iScience. 2023;26:106773 pubmed publisher
Zanini F, Che X, Knutsen C, Liu M, Suresh N, Domingo Gonzalez R, et al. Developmental diversity and unique sensitivity to injury of lung endothelial subtypes during postnatal growth. iScience. 2023;26:106097 pubmed publisher
Ge Y, Zadeh M, Mohamadzadeh M. Dissociation and flow cytometric isolation of murine intestinal epithelial cells for multi-omic profiling. STAR Protoc. 2023;4:101936 pubmed publisher
Wei M, Zuo S, Chen Z, Qian P, Zhang Y, Kong L, et al. Oncolytic vaccinia virus expressing a bispecific T-cell engager enhances immune responses in EpCAM positive solid tumors. Front Immunol. 2022;13:1017574 pubmed publisher
Xu L, Wei C, Chen Y, Wu Y, Shou X, Chen W, et al. IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection. Nat Commun. 2022;13:6881 pubmed publisher
Ghosh S, Kumar M, Santiana M, Mishra A, Zhang M, Labayo H, et al. Enteric viruses replicate in salivary glands and infect through saliva. Nature. 2022;607:345-350 pubmed publisher
Mauduit O, Aure M, Delcroix V, Basova L, Srivastava A, Umazume T, et al. A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands. Cell Rep. 2022;39:110663 pubmed publisher
Kumar B, Adebayo A, Prasad M, Capitano M, Wang R, Bhat Nakshatri P, et al. Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity. Sci Adv. 2022;8:eabh3375 pubmed publisher
Heino S, Fang S, Lähde M, Högström J, Nassiri S, Campbell A, et al. Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas. Sci Adv. 2021;7:eabj0512 pubmed publisher
Lin C, Chen M, Lin L, Christian D, Min B, Hunter C, et al. Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes. J Exp Med. 2021;218: pubmed publisher
Elmentaite R, Kumasaka N, Roberts K, FLEMING A, Dann E, King H, et al. Cells of the human intestinal tract mapped across space and time. Nature. 2021;597:250-255 pubmed publisher
Yip H, Papa A. Generation and functional characterization of murine mammary organoids. STAR Protoc. 2021;2:100765 pubmed publisher
Cordero Espinoza L, Dowbaj A, Kohler T, Strauss B, Sarlidou O, Belenguer G, et al. Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation. Cell Stem Cell. 2021;28:1907-1921.e8 pubmed publisher
Belicova L, Repnik U, Delpierre J, Gralinska E, Seifert S, Valenzuela J, et al. Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads. J Cell Biol. 2021;220: pubmed publisher
Shani O, Raz Y, Monteran L, Scharff Y, Levi Galibov O, Megides O, et al. Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity. elife. 2021;10: pubmed publisher
Goga A, Yagabasan B, Herrmanns K, Godbersen S, Silva P, Denzler R, et al. miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine. Nat Commun. 2021;12:3339 pubmed publisher
Teng Y, Xu F, Zhang X, Mu J, Sayed M, Hu X, et al. Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12. Mol Ther. 2021;29:2424-2440 pubmed publisher
Chen Q, Liu Y. Isolation and culture of mouse alveolar type II cells to study type II to type I cell differentiation. STAR Protoc. 2021;2:100241 pubmed publisher
Giraud J, Foroutan M, Boubaker Vitre J, Grillet F, Homayed Z, Jadhav U, et al. Progastrin production transitions from Bmi1+/Prox1+ to Lgr5high cells during early intestinal tumorigenesis. Transl Oncol. 2021;14:101001 pubmed publisher
Cheong S, Akram K, Matellan C, Kim S, Gaboriau D, Hind M, et al. The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling. Front Cell Dev Biol. 2020;8:577201 pubmed publisher
Wen X, Zhang J, Wan X, Frank A, Qu X, Kellum J. Tissue Inhibitor of Metalloproteinases-2 Mediates Kidney Injury during Sepsis. Nephron. 2020;144:644-649 pubmed publisher
Cousins F, Farley J, Kerrigan R, Mukherjee S, Darzi S, Gargett C, et al. The effects of hedgehog ligand neutralising antibody 5E1 in a mouse model of endometriosis. BMC Res Notes. 2020;13:454 pubmed publisher
Tang D, Xu X, Ying J, Xie T, Cao G. Transfer of metastatic traits via miR-200c in extracellular vesicles derived from colorectal cancer stem cells is inhibited by atractylenolide I. Clin Transl Med. 2020;10:e139 pubmed publisher
Remmerie A, Martens L, Thoné T, Castoldi A, Seurinck R, Pavie B, et al. Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver. Immunity. 2020;53:641-657.e14 pubmed publisher
Li Z, Xiao Y, Peng J, Locke D, Holmes D, Li L, et al. Quantifying drug tissue biodistribution by integrating high content screening with deep-learning analysis. Sci Rep. 2020;10:14408 pubmed publisher
Ko H, Hong S, Verma R, Jung J, Lee M, Kim N, et al. Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103+CD11b+ Dendritic Cells. Front Immunol. 2020;11:1897 pubmed publisher
Wang X, Yang L, Wang Y, Xu Z, Feng Y, Zhang J, et al. Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level. Cell Res. 2020;30:1109-1126 pubmed publisher
Martinez L, Garcia G, Contreras D, Gong D, Sun R, Arumugaswami V. Zika Virus Mucosal Infection Provides Protective Immunity. J Virol. 2020;94: pubmed publisher
Saborowski A, Wolff K, Spielberg S, Beer B, Hartleben B, Erlangga Z, et al. Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer InVivo and In Vitro. Hepatol Commun. 2019;3:423-436 pubmed publisher
Li Z, Scott M, Brzoska T, Sundd P, Li Y, Billiar T, et al. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages. Mil Med Res. 2018;5:24 pubmed publisher
de Aguiar Vallim T, Lee E, Merriott D, Goulbourne C, Cheng J, Cheng A, et al. ABCG1 regulates pulmonary surfactant metabolism in mice and men. J Lipid Res. 2017;58:941-954 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD326 (EpCAM) Monoclonal Antibody (G8.8), Super Bright 645, eBioscience
Catalog # :
64-5791-82
Quantity :
100 ug
Price :
US 394.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 ug/test
Species :
Mouse
Clone :
G8.8
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types. Also, Ep-CAM reportedly distinguishes adenocarcinomas from pleural mesotheliomas.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test
Aliases :
adenocarcinoma-associated antigen; CD326; cell surface glycoprotein Trop-1; DIAR5; EGP; EGP-2; EGP314; EGP40; EPCAM; Ep-CAM; EpCAM1; epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; ESA; GA733-2; gp40; hEGP314; HNPCC8; human epithelial glycoprotein-2; KS 1/4 antigen; KS1/4; KSA; Ly74; lymphocyte antigen 74; M1S2; M4S1; major gastrointestinal tumor-associated protein GA733-2; mEGP314; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; panepithelial glycoprotein 314; protein 289A; Protein D5.7A; Tacsd1; Tacstd1; TROP1; Trop-1 protein; Tumor-associated calcium signal transducer 1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA