This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD117 (c-Kit) Monoclonal Antibody (2B8), Super Bright 645, eBioscience
catalog :
64-1171-82
quantity :
100 ug
price :
US 391.00
clonality :
monoclonal
host :
rat
conjugate :
Super Bright 645
clone name :
2B8

The same clone is also sold as:
reactivity :
mouse, pigs
application :
flow cytometry
citations: 27
Reference
Chan A, Han L, Delaney C, Wang X, Mukhaleva E, Li M, et al. Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Sci Adv. 2024;10:eadk3127 pubmed publisher
Rossi G, Giger S, H xfc bscher T, Lutolf M. Gastruloids as in vitro models of embryonic blood development with spatial and temporal resolution. Sci Rep. 2022;12:13380 pubmed publisher
Li J, Li X, Sun W, Zhang J, Yan Q, Wu J, et al. Specific overexpression of SIRT1 in mesenchymal stem cells rescues hematopoiesis niche in BMI1 knockout mice through promoting CXCL12 expression. Int J Biol Sci. 2022;18:2091-2103 pubmed publisher
Lee D, Lee Y, Park S, Park H, Kang H, Kim J. Preventive Effects of a Human Hematopoietic Mesenchymal Stem Cell (hHMSC) Therapy in Ovalbumin-Induced Food Allergy. Biomedicines. 2022;10: pubmed publisher
Leong E, Pang Z, Stadnyk A, Lin T. Calcineurin Aα Contributes to IgE-Dependent Mast-Cell Mediator Secretion in Allergic Inflammation. J Innate Immun. 2022;14:320-334 pubmed publisher
Pattabiraman G, Liu Z, Paul M, Schaeffer A, Thumbikat P. mMCP7, a Mouse Ortholog of δ Tryptase, Mediates Pelvic Tactile Allodynia in a Model of Chronic Pelvic Pain. Front Pain Res (Lausanne). 2021;2:805136 pubmed publisher
Majumdar D, Pietras E, Pawar S. Analysis of Radiation-Induced Changes in Cell Cycle and DNA Damage of Murine Hematopoietic Stem Cells by Multi-Color Flow Cytometry. Curr Protoc. 2021;1:e216 pubmed publisher
Fu Z, Dean J, Xiong L, Dougherty M, Oliff K, Chen Z, et al. Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism. Nat Commun. 2021;12:4462 pubmed publisher
Cardenas R, Gonzalez R, Sanchez E, Ramos M, Cardenas E, Rodarte A, et al. SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis. J Biol Chem. 2021;296:100268 pubmed publisher
Furuyama S, Wu Q, Varnum Finney B, Sandstrom R, Meuleman W, Stamatoyannopoulos J, et al. Inaccessible LCG Promoters Act as Safeguards to Restrict T Cell Development to Appropriate Notch Signaling Environments. Stem Cell Reports. 2021;16:717-726 pubmed publisher
van den Berk P, Lancini C, Company C, Serresi M, Sanchez Bailon M, Hulsman D, et al. USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells. Cell Rep. 2020;33:108533 pubmed publisher
Hong Y, Singh N, Bamopoulos S, Gjerga E, Schmalbrock L, Balabanian K, et al. Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System. Biomedicines. 2020;8: pubmed publisher
Koeniger T, Bell L, Mifka A, Enders M, Hautmann V, Mekala S, et al. Bone marrow-derived myeloid progenitors in the leptomeninges of adult mice. Stem Cells. 2021;39:227-239 pubmed publisher
Darzianiazizi M, Mehrani Y, Chan L, Mould R, Kulkarni R, Sharif S, et al. Type I Interferon α/β Receptor-Mediated Signaling Negatively Regulates Antiviral Cytokine Responses in Murine Bone-Marrow-Derived Mast Cells and Protects the Cells from Virus-Induced Cell Death. Int J Mol Sci. 2020;21: pubmed publisher
Zheng Y, Wang N, Wang S, Yang B, Situ H, Zhong L, et al. XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling. Cell Commun Signal. 2020;18:48 pubmed publisher
Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, et al. Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. EMBO J. 2017;36:840-853 pubmed publisher
Costa D, Principi E, Lazzarini E, Descalzi F, Cancedda R, Castagnola P, et al. LCN2 overexpression in bone enhances the hematopoietic compartment via modulation of the bone marrow microenvironment. J Cell Physiol. 2017;232:3077-3087 pubmed publisher
Hidaka T, Ogawa E, Kobayashi E, Suzuki T, Funayama R, Nagashima T, et al. The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nat Immunol. 2017;18:64-73 pubmed publisher
Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, et al. Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis. J Clin Invest. 2016;126:4497-4515 pubmed publisher
Dong L, Yu W, Zheng H, Loh M, Bunting S, Pauly M, et al. Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment. Nature. 2016;539:304-308 pubmed publisher
Bellio M, Rodrigues C, Landin A, Hatzistergos K, Kuznetsov J, Florea V, et al. Physiological and hypoxic oxygen concentration differentially regulates human c-Kit+ cardiac stem cell proliferation and migration. Am J Physiol Heart Circ Physiol. 2016;311:H1509-H1519 pubmed publisher
Cole C, Verdoni A, Ketkar S, Leight E, Russler Germain D, Lamprecht T, et al. PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia. J Clin Invest. 2016;126:85-98 pubmed publisher
Zoch A, Mayerl S, Schulz A, Greither T, Frappart L, Rübsam J, et al. Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation. PLoS ONE. 2015;10:e0129151 pubmed publisher
Hodgkinson C, Gomez J, Payne A, Zhang L, Wang X, Dal Pra S, et al. Abi3bp regulates cardiac progenitor cell proliferation and differentiation. Circ Res. 2014;115:1007-16 pubmed publisher
Honarpour N, Rose C, Brumbaugh J, Anderson J, Graham R, Sweredoski M, et al. F-box protein FBXL16 binds PP2A-B55? and regulates differentiation of embryonic stem cells along the FLK1+ lineage. Mol Cell Proteomics. 2014;13:780-91 pubmed publisher
Agrawal V, Siu B, Chao H, Hirschi K, Raborn E, Johnson S, et al. Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation. Tissue Eng Part A. 2012;18:1454-63 pubmed publisher
Zuber J, Shi J, Wang E, Rappaport A, Herrmann H, Sison E, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011;478:524-8 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD117 (c-Kit) Monoclonal Antibody (2B8), Super Bright 645, eBioscience
Catalog # :
64-1171-82
Quantity :
100 ug
Price :
US 391.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse, Porcine
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Mouse, Porcine
Clone :
2B8
Isotype :
IgG2b, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA