Podoplanin Monoclonal Antibody (eBio8.1.1 (8.1.1)), Super Bright 600, eBioscience | Invitrogen 63-5381-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Podoplanin Monoclonal Antibody (eBio8.1.1 (8.1.1)), Super Bright 600, eBioscience

catalog :

63-5381-82

quantity :

100 ug

price :

US 405.00

clonality :

monoclonal

host :

Syrian golden hamster

conjugate :

Super Bright 600

clone name :

eBio8.1.1 (8.1.1)

reactivity :

mouse

application :

flow cytometry

citations: 11

Reference
Schnabellehner S, Kraft M, Schoofs H, Orts xe4 ter H, M xe4 kinen T. Penile cavernous sinusoids are Prox1-positive hybrid vessels. Vasc Biol. 2024;6: pubmed publisher
Sakarya A, Huang C, Yang C, Hsiao H, Chang F, Huang J. Vascularized lymph node transplantation successfully reverses lymphedema and maintains immunity in a rat lymphedema model. Bioeng Transl Med. 2022;7:e10301 pubmed publisher
Na E, Allen E, Baird L, Odom C, Korkmaz F, Shenoy A, et al. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2022;322:L550-L563 pubmed publisher
Chen Y, Zhang T, Yao F, Gao X, Li D, Fu S, et al. Dysregulation of interaction between LOXhigh fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissection. Theranostics. 2022;12:910-928 pubmed publisher
Tang C, Wang L, Sheng Y, Zheng Z, Xie Z, Wu F, et al. CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice. Theranostics. 2021;11:9791-9804 pubmed publisher
de Winde C, Makris S, Millward L, Cantoral Rebordinos J, Benjamin A, Mart xed nez V, et al. Fibroblastic reticular cell response to dendritic cells requires coordinated activity of podoplanin, CD44 and CD9. J Cell Sci. 2021;134: pubmed publisher
Prados A, Onder L, Cheng H, Mörbe U, Lütge M, Gil Cruz C, et al. Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity. Nat Immunol. 2021;22:510-519 pubmed publisher
Thacker V, Dhar N, Sharma K, Barrile R, Karalis K, McKinney J. A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth. elife. 2020;9: pubmed publisher
Fujimoto N, He Y, D Addio M, Tacconi C, Detmar M, Dieterich L. Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes. PLoS Biol. 2020;18:e3000704 pubmed publisher
Dieterich L, Kapaklikaya K, Cetintas T, Proulx S, Commerford C, Ikenberg K, et al. Transcriptional profiling of breast cancer-associated lymphatic vessels reveals VCAM-1 as regulator of lymphatic invasion and permeability. Int J Cancer. 2019;145:2804-2815 pubmed publisher
Blanco S, Bandiera R, Popis M, Hussain S, Lombard P, Aleksic J, et al. Stem cell function and stress response are controlled by protein synthesis. Nature. 2016;534:335-40 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Podoplanin Monoclonal Antibody (eBio8.1.1 (8.1.1)), Super Bright 600, eBioscience

Catalog # :

63-5381-82

Quantity :

100 ug

Price :

US 405.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Syrian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.125 ug/test

Species :

Mouse

Clone :

eBio8.1.1 (8.1.1)

Isotype :

IgG

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.125 ug/test

Aliases :

29kDa cytosolic podoplanin intracellular domain; Aggrus; CTA-520D8.1; E11; E11 antigen epitope; epithelial cell surface transmembrane protein antigen; glycoprotein 36; Glycoprotein 38; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); Ots8; OTS-8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; PDPN; PICD; Podoplanin; PSEC0003; PSEC0025; pulmonary type I alveolar epithelial cell transmembrane differentiation marker; RANDAM-2; RP23-348F1.2; RTI140; RTI40; T1a; T1A2; T1A-2; T1alpha; T1-alpha; TI1A; Transmembrane glycoprotein E11; type I cell 40 kDa protein