This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD115 (c-fms) Monoclonal Antibody (AFS98), Super Bright 600, eBioscience
catalog :
63-1152-82
quantity :
100 ug
price :
US 392.00
clonality :
monoclonal
host :
rat
conjugate :
Super Bright 600
clone name :
AFS98

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 21
Reference
Eren R, Kaya G, Schwarzer R, Pasparakis M. IKKε and TBK1 prevent RIPK1 dependent and independent inflammation. Nat Commun. 2024;15:130 pubmed publisher
Mills K, Du Y, Coughlin J, Foss C, Horti A, Jenkins K, et al. Exploring [11C]CPPC as a CSF1R-targeted PET Imaging Marker for Early Parkinson's Disease Severity. medRxiv. 2024;: pubmed publisher
Ibrahim T, Wu P, Wang L, Fang Mei C, Murillo J, Merlo J, et al. Sex-dependent differences in the genomic profile of lingual sensory neurons in naïve and tongue-tumor bearing mice. Sci Rep. 2023;13:13117 pubmed publisher
Kocat xfc rk B, Lee Y, Nosaka N, Abe M, Martinon D, Lane M, et al. Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2023;8: pubmed publisher
Zhang W, Jiang X, ZOU Y, Yuan L, Wang X. Pexidartinib synergize PD-1 antibody through inhibiting treg infiltration by reducing TAM-derived CCL22 in lung adenocarcinoma. Front Pharmacol. 2023;14:1092767 pubmed publisher
Meyers A, Wang Z, Han W, Zhao Q, Zabalawi M, Duan L, et al. Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation. Cell Rep. 2023;42:111941 pubmed publisher
Yan Q, Gao H, Yao Q, Ling K, Xiao G. Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling. J Biol Chem. 2022;298:101639 pubmed publisher
Feng L, Li C, Zeng L, Gao D, Sun Y, Zhong L, et al. MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα. Signal Transduct Target Ther. 2022;7:21 pubmed publisher
Oladiran O, Shi X, Fournier S, Zhang J. CX3CR1 But Not CCR2 Expression Is Required for the Development of Autoimmune Peripheral Neuropathy in Mice. Front Immunol. 2021;12:720733 pubmed publisher
La Rose A, Bazioti V, Hoogerland J, Svendsen A, Groenen A, van Faassen M, et al. Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia. Mol Metab. 2021;53:101265 pubmed publisher
Fu J, Shih L, Yen T. HOXA11 plays critical roles in disease progression and response to cytarabine in AML. Oncol Rep. 2021;46: pubmed publisher
Serrano López J, Hegde S, Kumar S, Serrano J, Fang J, Wellendorf A, et al. Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. elife. 2021;10: pubmed publisher
Oladiran O, Shi X, Yang M, Fournier S, Zhang J. Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy. J Neuroinflammation. 2021;18:77 pubmed publisher
Wieghofer P, Hagemeyer N, Sankowski R, Schlecht A, Staszewski O, Amann L, et al. Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling. EMBO J. 2021;40:e105123 pubmed publisher
Consiglio C, Gollnick S. Androgen Receptor Signaling Positively Regulates Monocytic Development. Front Immunol. 2020;11:519383 pubmed publisher
Christofi M, Le Sommer S, Molzer C, Klaska I, Kuffova L, Forrester J. Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects. Cell Mol Life Sci. 2021;78:2857-2876 pubmed publisher
Xiao J, Wang C, Yao J, Alippe Y, Yang T, Kress D, et al. Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells. PLoS Biol. 2020;18:e3000807 pubmed publisher
Boeck M, Thien A, Wolf J, Hagemeyer N, Laich Y, Yusuf D, et al. Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model. Glia. 2020;68:1859-1873 pubmed publisher
Tong Y, Zhou L, Yang L, Guo P, Cao Y, Qin F, et al. Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production. EBioMedicine. 2019;39:132-144 pubmed publisher
Corey S, Jha J, McCart E, Rittase W, George J, Mattapallil J, et al. Captopril mitigates splenomegaly and myelofibrosis in the Gata1low murine model of myelofibrosis. J Cell Mol Med. 2018;22:4274-4282 pubmed publisher
Tang J, Frey J, Wilson C, Moncada Pazos A, Levet C, Freeman M, et al. Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation. Mol Cell Biol. 2018;38: pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD115 (c-fms) Monoclonal Antibody (AFS98), Super Bright 600, eBioscience
Catalog # :
63-1152-82
Quantity :
100 ug
Price :
US 392.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Mouse
Clone :
AFS98
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
AI323359; CD115; CD115 antigen; C-FMS; colony stimulating factor 1 receptor; colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1 receptor; CSF1R; CSF-1R; CSF-1-R; CSFIR; Csfmr; CSFR; EC 2.7.10.1; FIM2; Fim-2; FMS; fms proto-oncogene; HDLS; kinase CSFR; macrophage colony stimulating factor I receptor; macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; M-CSFR; M-CSF-R; mrfms; OTTHUMP00000224093; protein-tyrosine kinase; proto-oncogene c-Fms; proto-oncogene fms
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA