This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD25 Monoclonal Antibody (BC96), Super Bright 600, eBioscience
catalog :
63-0259-42
quantity :
100 Tests
price :
US 392.00
clonality :
monoclonal
host :
mouse
conjugate :
Super Bright 600
clone name :
BC96

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
citations: 39
Reference
Dai Q, Shi R, Zhang G, Wang Y, Ye L, Peng L, et al. miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK. Exp Biol Med (Maywood). 2024;249:10111 pubmed publisher
Preglej T, Brinkmann M, Steiner G, Aletaha D, G xf6 schl L, Bonelli M. Advanced immunophenotyping: A powerful tool for immune profiling, drug screening, and a personalized treatment approach. Front Immunol. 2023;14:1096096 pubmed publisher
Huang T, Cheng L, Jiang Y, Zhang L, Qian L. Indole-3-pyruvic acid alleviates rheumatoid arthritis via the aryl hydrocarbon receptor pathway. Ann Transl Med. 2023;11:213 pubmed publisher
Chen A, Cao J, Chen H, Du H, Xi X, Sun J, et al. Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner. Front Aging Neurosci. 2022;14:842380 pubmed publisher
You Y, Huang S, Liu H, Fan C, Liu K, Wang Z. Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function. Mol Med Rep. 2021;24: pubmed publisher
Jarrell J, Sytsma B, Wilson L, Pan F, Lau K, Kirby G, et al. Numerical optimization of microfluidic vortex shedding for genome editing T cells with Cas9. Sci Rep. 2021;11:11818 pubmed publisher
Chang G, Yang X, Liu W, Lin S, Yang S, Zhao M. FABP4 facilitates inflammasome activation to induce the Treg/Th17 imbalance in preeclampsia via forming a positive feedback with IL-17A. Mol Ther Nucleic Acids. 2021;24:743-754 pubmed publisher
Zhong L, Shi W, Gan L, Liu X, Huo Y, Wu P, et al. Human endoglin-CD3 bispecific T cell engager antibody induces anti-tumor effect in vivo. Theranostics. 2021;11:6393-6406 pubmed publisher
Harb H, Benamar M, Lai P, Contini P, Griffith J, Crestani E, et al. Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections. Immunity. 2021;54:1186-1199.e7 pubmed publisher
Liu H, Hu P, Dubrulle J, Stossi F, Nikolai B, Mancini M, et al. Identification of celastrol as a novel HIV-1 latency reversal agent by an image-based screen. PLoS ONE. 2021;16:e0244771 pubmed publisher
Li W, Luo Y, Xu H, Ma Q, Yao Q. Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice. J Int Med Res. 2021;49:300060521998471 pubmed publisher
Yang P, Tian H, Zou Y, Chambon P, Ichinose H, Honig G, et al. Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis. Front Immunol. 2021;12:616583 pubmed publisher
Tewari R, Shayahati B, Fan Y, Akimzhanov A. T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells. J Biol Chem. 2021;:100311 pubmed publisher
Kasatskaya S, Ladell K, Egorov E, Miners K, Davydov A, Metsger M, et al. Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs. elife. 2020;9: pubmed publisher
Zu J, Yao L, Song Y, Cui Y, Guan M, Chen R, et al. Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa. Front Immunol. 2020;11:570888 pubmed publisher
Marshall L, Marubayashi S, Jorapur A, Jacobson S, Zibinsky M, Robles O, et al. Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4. J Immunother Cancer. 2020;8: pubmed publisher
Chandrashekara S, Lingaraju D, Renuka P, Anupama K. Potential of neutrophil to lymphocyte ratio in predicting sustained remission in rheumatoid arthritis compared to other immune activation markers. Indian J Med Res. 2020;152:234-243 pubmed publisher
He J, Xu Y, Yi M, Gu C, Zhu Y, Hu G. Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain. J Int Med Res. 2020;48:300060519871407 pubmed publisher
Henderson L, Hoyt K, Lee P, Rao D, Jonsson A, Nguyen J, et al. Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. JCI Insight. 2020;5: pubmed publisher
Mühlberger M, Unterweger H, Band J, Lehmann C, Heger L, Dudziak D, et al. Loading of Primary Human T Lymphocytes with Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles Does Not Impair Their Activation after Polyclonal Stimulation. Cells. 2020;9: pubmed publisher
Gonzalo Gil E, Rapuano P, Ikediobi U, Leibowitz R, Mehta S, Coskun A, et al. Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members. elife. 2019;8: pubmed publisher
Yang X, Zeng Q, Göktaş E, Gopal K, Al Aswad L, Blumberg D, et al. T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma. Invest Ophthalmol Vis Sci. 2019;60:877-888 pubmed publisher
Guo X, Jiang H, Shi B, Zhou M, Zhang H, Shi Z, et al. Disruption of PD-1 Enhanced the Anti-tumor Activity of Chimeric Antigen Receptor T Cells Against Hepatocellular Carcinoma. Front Pharmacol. 2018;9:1118 pubmed publisher
Ding J, Zhou T, Zheng X, Wang X, Tong X, Luo C, et al. The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis. Acta Cardiol Sin. 2018;34:399-408 pubmed publisher
Tankou S, Regev K, Healy B, Tjon E, Laghi L, Cox L, et al. A probiotic modulates the microbiome and immunity in multiple sclerosis. Ann Neurol. 2018;83:1147-1161 pubmed publisher
Dimitrov V, Bouttier M, Boukhaled G, Salehi Tabar R, Avramescu R, Memari B, et al. Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice. J Biol Chem. 2017;292:20657-20668 pubmed publisher
Sha J, Liu F, Zhai J, Liu X, Zhang Q, Zhang B. Alteration of Th17 and Foxp3+ regulatory T cells in patients with unexplained recurrent spontaneous abortion before and after the therapy of hCG combined with immunoglobulin. Exp Ther Med. 2017;14:1114-1118 pubmed publisher
Albert B, Niu A, Ramani R, Marshall G, Wender P, Williams R, et al. Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation. Sci Rep. 2017;7:7456 pubmed publisher
Kim J, Kwon C, Joh J, Sinn D, Choi G, Park J, et al. Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients. Med Princ Pract. 2017;26:221-228 pubmed publisher
La Porta J, Matus Nicodemos R, Valentin Acevedo A, Covey L. The RNA-Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation. PLoS ONE. 2016;11:e0158708 pubmed publisher
Zhao J, Ma J, Zhang X, Li Q, Yang X. Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance. Exp Ther Med. 2016;11:2300-2304 pubmed
Macdonald K, Hoeppli R, Huang Q, Gillies J, Luciani D, Orban P, et al. Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. J Clin Invest. 2016;126:1413-24 pubmed publisher
Legorreta Haquet M, Chávez Rueda K, Chávez Sánchez L, Cervera Castillo H, Zenteno Galindo E, Barile Fabris L, et al. Function of Treg Cells Decreased in Patients With Systemic Lupus Erythematosus Due To the Effect of Prolactin. Medicine (Baltimore). 2016;95:e2384 pubmed publisher
Younis R, Han K, Webb T. Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells. J Immunol. 2016;196:1419-29 pubmed publisher
Jabara H, Boyden S, Chou J, Ramesh N, Massaad M, Benson H, et al. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet. 2016;48:74-8 pubmed publisher
Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed publisher
Li J, Chen Q, Mo H, Zhang Y, Huang Z, Zeng Y. Immunophenotyping at the time of diagnosis distinguishes two groups of nasopharyngeal carcinoma patients: implications for adoptive immunotherapy. Int J Biol Sci. 2011;7:607-17 pubmed
Cubillos Ruiz J, Martinez D, Scarlett U, Rutkowski M, Nesbeth Y, Camposeco Jacobs A, et al. CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells. Oncotarget. 2010;1:329-38 pubmed
Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009;182:7518-26 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD25 Monoclonal Antibody (BC96), Super Bright 600, eBioscience
Catalog # :
63-0259-42
Quantity :
100 Tests
Price :
US 392.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.5 ug)/test
Species :
Human
Clone :
BC96
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.5 ug)/test
Aliases :
ADA; ADA1; Adenosine aminohydrolase; adenosine deaminase; CD25; CD25 antigen; cytokine receptor; IDDM10; IL 2 RA; IL 2 receptor; IL 2R; IL 2R subunit alpha; IL2 RA; IL2 RA antibody; IL2 receptor; il-2 receptor alpha; IL-2 Receptor alpha chain; IL-2 receptor alpha subunit; IL2 receptor subunit alpha; IL-2 receptor subunit alpha; IL2R; IL-2R alpha; IL-2R alpha chain; IL2R subunit alpha; IL-2R subunit alpha; Il2ra; IL-2RA; IL-2-RA; IL2-RA; Il2ra antibody; IL2RAC; IMD41; interleukin 2 receptor; interleukin 2 receptor alpha chain; interleukin 2 receptor subunit alpha; interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain; interleukin-2 receptor alpha; interleukin-2 receptor alpha chain; interleukin-2 receptor alpha subunit; interleukin-2 receptor beta chain; Interleukin2 receptor subunit alpha; interleukin-2 receptor subunit alpha; Ly-43; p55; p55 chain; sIL 2R; soluble IL 2 receptor; TAC antigen; TCGFR
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA