CD184 (CXCR4) Monoclonal Antibody (12G5), Super Bright 436, eBioscience™ | Invitrogen 62-9999-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD184 (CXCR4) Monoclonal Antibody (12G5), Super Bright 436, eBioscience™

catalog :

62-9999-41

quantity :

25Tests

price :

US 149.00

clonality :

monoclonal

host :

mouse

conjugate :

Super Bright 436

clone name :

12G5

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Strazza M, Azoulay Alfaguter I, Peled M, Smrcka A, Skolnik E, Srivastava S, et al. PLCÎµ1 regulates SDF-1Î±-induced lymphocyte adhesion and migration to sites of inflammation. Proc Natl Acad Sci U S A. 2017;114:2693-2698 pubmed publisher
Hajjar I, Goldstein F, Waller E, Moss L, Quyyumi A. Circulating Progenitor Cells is Linked to Cognitive Decline in Healthy Adults. Am J Med Sci. 2016;351:147-52 pubmed publisher
Lai L, Vödrös D, Kozlowski P, Montefiori D, Wilson R, Akerstrom V, et al. GM-CSF DNA: an adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine. Virology. 2007;369:153-67 pubmed

product information

Product Type :

Antibody

Product Name :

CD184 (CXCR4) Monoclonal Antibody (12G5), Super Bright 436, eBioscience™

Catalog # :

62-9999-41

Quantity :

25Tests

Price :

US 149.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µl (0.125 µg)/Test

Species :

Human

Clone :

12G5

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µl (0.125 µg)/Test

Aliases :

Fusin