This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD40 Monoclonal Antibody (1C10), Super Bright 436, eBioscience
catalog :
62-0401-82
quantity :
100 ug
price :
US 378.00
clonality :
monoclonal
host :
rat
conjugate :
Super Bright 436
clone name :
1C10

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 16
Reference
Liu C, Guo S, Liu R, Guo M, Wang Q, Chai Z, et al. Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis. Neural Regen Res. 2024;19:671-679 pubmed publisher
Ramzy A, Soliman A, Hassanein S, Sebak A. Multitarget, multiagent PLGA nanoparticles for simultaneous tumor eradication and TME remodeling in a melanoma mouse model. Drug Deliv Transl Res. 2024;14:491-509 pubmed publisher
Lutz M, Ali S, Audiger C, Autenrieth S, Berod L, Bigley V, et al. Guidelines for mouse and human DC generation. Eur J Immunol. 2022;: pubmed publisher
Wang Z, Xu F, Hu J, Zhang H, Cui L, Lu W, et al. Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity. J Immunother Cancer. 2021;9: pubmed publisher
Agalave N, Mody P, Szabo Pardi T, Jeong H, Burton M. Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy. Front Immunol. 2021;12:642420 pubmed publisher
Diao G, Huang J, Zheng X, Sun X, Tian M, Han J, et al. Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells. Int J Mol Med. 2021;47:207-218 pubmed publisher
Chen H, Tan J, Li X, Li H, Wu W, Wu Y, et al. Myeloid and plasmacytoid dendritic cell combined vaccines loaded with heat-treated tumor cell lysates enhance antitumor activity in murine lung cancer. Oncol Lett. 2021;21:90 pubmed publisher
Darling R, Senapati S, Christiansen J, Liu L, Ramer Tait A, Narasimhan B, et al. Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8+ T Cell Memory and Delayed Tumor Progression. Int J Nanomedicine. 2020;15:6579-6592 pubmed publisher
Iske J, Seyda M, Heinbokel T, Maenosono R, Minami K, Nian Y, et al. Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation. Nat Commun. 2020;11:4289 pubmed publisher
Kedzierska A, Lorek D, Slawek A, Chelmonska Soyta A. Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings. Sci Rep. 2020;10:10531 pubmed publisher
Huang J, Diao G, Zhang Q, Chen Y, Han J, Guo J. E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions. Int J Oncol. 2020;56:921-931 pubmed publisher
Andersohn A, Garcia M, Fan Y, Thompson M, Akimzhanov A, Abdullahi A, et al. Aggregated and Hyperstable Damage-Associated Molecular Patterns Are Released During ER Stress to Modulate Immune Function. Front Cell Dev Biol. 2019;7:198 pubmed publisher
Wang Z, Chen J, Hu J, Zhang H, Xu F, He W, et al. cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity. J Clin Invest. 2019;129:4850-4862 pubmed publisher
Serradell M, Rupil L, Martino R, Prucca C, Carranza P, Saura A, et al. Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins. Nat Commun. 2019;10:361 pubmed publisher
Shen Y, Guo D, Weng L, Wang S, Ma Z, Yang Y, et al. Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway. Oncoimmunology. 2017;6:e1362527 pubmed publisher
Zhang H, Qi Y, Yuan Y, Cai L, Xu H, Zhang L, et al. Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation. Sci Rep. 2017;7:41887 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD40 Monoclonal Antibody (1C10), Super Bright 436, eBioscience
Catalog # :
62-0401-82
Quantity :
100 ug
Price :
US 378.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Mouse
Clone :
1C10
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
AI326936; B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; Cd40; CD40 antigen; CD40 antigen (TNF receptor superfamily member 5); CD40 antigen, TNF receptor superfamily member 5; CD40 molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; GP39; HIGM1; I79_006806; IGM; IMD3; Immunoglobulin M; ImmunoglobulinM; membrane protein CD40; MGC9013; p50; receptor for ligand CD154; sCD40; soluble CD40; T-BAM; T-cell differentiation antigen; Tnfrsf5; TRAP; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA