This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD278 (ICOS) Monoclonal Antibody (ISA-3), PE-eFluor 610, eBioscience
catalog :
61-9948-42
quantity :
100 Tests
price :
US 435.00
clonality :
monoclonal
host :
mouse
conjugate :
PE-eFluor 610
clone name :
ISA-3

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
citations: 14
Reference
Hill D, Whyte C, Innocentin S, Lee J, Dooley J, Wang J, et al. Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans. elife. 2021;10: pubmed publisher
Dart S, Cook A, Millward M, McDonnell A, Chin W, Hakeem M, et al. Changes in expression of PD-L1 on peripheral T cells in patients with melanoma and lung cancer treated with PD-1 inhibitors. Sci Rep. 2021;11:15312 pubmed publisher
Khanam A, Ayithan N, Tang L, Poonia B, Kottilil S. IL-21-Deficient T Follicular Helper Cells Support B Cell Responses Through IL-27 in Patients With Chronic Hepatitis B. Front Immunol. 2020;11:599648 pubmed publisher
Rodda L, Netland J, Shehata L, Pruner K, Morawski P, Thouvenel C, et al. Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Cell. 2021;184:169-183.e17 pubmed publisher
Hill D, Pierson W, Bolland D, Mkindi C, Carr E, Wang J, et al. The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes. J Exp Med. 2019;: pubmed publisher
Wang H, Kang X, Chu S, Li H, Li X, Yin X, et al. Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis. Exp Ther Med. 2018;16:3728-3734 pubmed publisher
Meng X, Yu X, Dong Q, Xu X, Li J, Xu Q, et al. Distribution of circulating follicular helper T cells and expression of interleukin-21 and chemokine C-X-C ligand 13 in gastric cancer. Oncol Lett. 2018;16:3917-3922 pubmed publisher
Gu Trantien C, Migliori E, Buisseret L, de Wind A, Brohée S, Garaud S, et al. CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer. JCI Insight. 2017;2: pubmed publisher
Tang Z, Hao Y, Zhang E, Xu C, Zhou Y, Zheng X, et al. CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade. Mol Med Rep. 2016;14:1107-16 pubmed publisher
Quiroga M, Pasquinelli V, Martinez G, Jurado J, Zorrilla L, Musella R, et al. Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis. J Immunol. 2006;176:5965-74 pubmed
Grimbacher B, Hutloff A, Schlesier M, Glocker E, Warnatz K, Dräger R, et al. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol. 2003;4:261-8 pubmed
Beier K, Hutloff A, Dittrich A, Heuck C, Rauch A, Buchner K, et al. Induction, binding specificity and function of human ICOS. Eur J Immunol. 2000;30:3707-17 pubmed
Buonfiglio D, Bragardo M, Redoglia V, Vaschetto R, Bottarel F, Bonissoni S, et al. The T cell activation molecule H4 and the CD28-like molecule ICOS are identical. Eur J Immunol. 2000;30:3463-7 pubmed
Hutloff A, Dittrich A, Beier K, Eljaschewitsch B, Kraft R, Anagnostopoulos I, et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 1999;397:263-6 pubmed
product information
Product Type :
Antibody
Product Name :
CD278 (ICOS) Monoclonal Antibody (ISA-3), PE-eFluor 610, eBioscience
Catalog # :
61-9948-42
Quantity :
100 Tests
Price :
US 435.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.25 ug)/test
Species :
Human
Clone :
ISA-3
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
ICOS (CD278) encodes a protein that is a member of the CD28 and CTLA-4 cell-surface receptor family. It functions as a homodimer and has a crucial role in cell-cell signaling, immune responses, and the regulation of cell proliferation. ICOS has been linked to various disorders, including Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.25 ug)/test
Aliases :
Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA