This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TNF alpha Monoclonal Antibody (MAb11), PE-eFluor 610, eBioscience
catalog :
61-7349-42
quantity :
100 Tests
price :
US 436.00
clonality :
monoclonal
host :
mouse
conjugate :
PE-eFluor 610
clone name :
MAb11

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
citations: 23
Reference
Laquintana V, Mottini C, Marchesi F, Marcozzi B, Terrenato I, Sperandio E, et al. Dynamics of humoral and cellular response to three doses of anti-SARS-CoV-2 BNT162b2 vaccine in patients with hematological malignancies and older subjects. Front Immunol. 2023;14:1221587 pubmed publisher
Yang J, Liu H, Zhang J, Zou J, Zhang X, Chen W, et al. The effect of metformin on senescence of T lymphocytes. Immun Ageing. 2023;20:73 pubmed publisher
Zeng L, Zheng W, Zhang J, Wang J, Ji Q, Wu X, et al. An epitope encoded by uORF of RNF10 elicits a therapeutic anti-tumor immune response. Mol Ther Oncolytics. 2023;31:100737 pubmed publisher
Lan Y, Yuan S, Guo T, Hou S, Zhao F, Yang W, et al. R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells. iScience. 2023;26:106817 pubmed publisher
Li Q, Zhang L, You W, Xu J, Dai J, Hua D, et al. PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells. Nat Commun. 2022;13:7677 pubmed publisher
Jeong H, Kim S, Jung M, Noh J, Yoo J, Kim E, et al. Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infection. Cell Rep Med. 2022;3:100764 pubmed publisher
Li H, Yang Z, Yang X, Zhang F, Wang J, Wu Z, et al. LINC01123 promotes immune escape by sponging miR-214-3p to regulate B7-H3 in head and neck squamous-cell carcinoma. Cell Death Dis. 2022;13:109 pubmed publisher
Ando M, Kondo T, Tomisato W, Ito M, Shichino S, Srirat T, et al. Rejuvenating Effector/Exhausted CAR T Cells to Stem Cell Memory-Like CAR T Cells By Resting Them in the Presence of CXCL12 and the NOTCH Ligand. Cancer Res Commun. 2021;1:41-55 pubmed publisher
Apostolidis S, Kakara M, Painter M, Goel R, Mathew D, Lenzi K, et al. Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nat Med. 2021;27:1990-2001 pubmed publisher
Wu B, Woo J, Vila P, Jew M, Leung J, Sun Z, et al. NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells. Cell Rep. 2021;36:109603 pubmed publisher
Kucka K, Lang I, Zhang T, Siegmund D, Medler J, Wajant H. Membrane lymphotoxin-α2β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist. Cell Death Dis. 2021;12:360 pubmed publisher
Iwabuchi R, Ide K, Terahara K, Wagatsuma R, Iwaki R, Matsunaga H, et al. Development of an Inflammatory CD14+ Dendritic Cell Subset in Humanized Mice. Front Immunol. 2021;12:643040 pubmed publisher
Hoang T, Pino M, Boddapati A, Viox E, Starke C, Upadhyay A, et al. Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques. Cell. 2021;184:460-475.e21 pubmed publisher
Trivedi S, Labuz D, Anderson C, Araújo C, Blair A, Middleton E, et al. Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis. elife. 2020;9: pubmed publisher
Lee J, Sheen J, Lim O, Lee Y, Ryu J, Shin D, et al. Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy. Sci Rep. 2020;10:17753 pubmed publisher
Huang B, Liu Y, Lai S, Lin H, Shen C, Yang L, et al. CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions. Int J Mol Sci. 2020;21: pubmed publisher
Zhao L, Liu Y, Zhao F, Jin Y, Feng J, Geng R, et al. Inhibition of Cholesterol Esterification Enzyme Enhances the Potency of Human Chimeric Antigen Receptor T Cells against Pancreatic Carcinoma. Mol Ther Oncolytics. 2020;16:262-271 pubmed publisher
Baguma R, Penn Nicholson A, Smit E, Erasmus M, Day J, Makhethe L, et al. Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population. PLoS ONE. 2017;12:e0184563 pubmed publisher
Jiménez Sánchez A, Memon D, Pourpe S, Veeraraghavan H, Li Y, Vargas H, et al. Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient. Cell. 2017;170:927-938.e20 pubmed publisher
Sheng S, Gu Y, Lu C, Zou J, Hong H, Wang R. The distribution and function of human memory T cell subsets in lung cancer. Immunol Res. 2017;65:639-650 pubmed publisher
Kusne Y, Carrera Silva E, Perry A, Rushing E, Mandell E, Dietrich J, et al. Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma. Sci Signal. 2014;7:ra75 pubmed publisher
Geevarghese B, Weinberg A. Cell-mediated immune responses to respiratory syncytial virus infection: magnitude, kinetics, and correlates with morbidity and age. Hum Vaccin Immunother. 2014;10:1047-56 pubmed
Di J, Massuger L, Duiveman de Boer T, Zusterzeel P, Figdor C, Torensma R. Functional OCT4-specific CD4+ and CD8+ T cells in healthy controls and ovarian cancer patients. Oncoimmunology. 2013;2:e24271 pubmed
product information
Product Type :
Antibody
Product Name :
TNF alpha Monoclonal Antibody (MAb11), PE-eFluor 610, eBioscience
Catalog # :
61-7349-42
Quantity :
100 Tests
Price :
US 436.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.25 ug)/test
Species :
Human
Clone :
MAb11
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.25 ug)/test
Aliases :
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA