This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Ly-6G/Ly-6C Monoclonal Antibody (RB6-8C5), PE-eFluor 610, eBioscience™
catalog :
61-5931-80
quantity :
25 µg
price :
US 309.00
clonality :
monoclonal
host :
rat
conjugate :
PE-eFluor 610
clone name :
RB6-8C5
reactivity :
mouse
application :
flow cytometry
citations: 54
Reference
Dokoshi T, Zhang L, Li F, Nakatsuji T, Butcher A, Yoshida H, et al. Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection. Cell Rep. 2020;30:61-68.e4 pubmed publisher
Calvente C, Tameda M, Johnson C, Del Pilar H, Lin Y, Adronikou N, et al. Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. J Clin Invest. 2019;129:4091-4109 pubmed publisher
Wang N, Yang X, Sun J, Sun Z, Ma Q, Wang Z, et al. Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection. Cell Death Discov. 2019;5:111 pubmed publisher
Geng X, Wang X, Luo M, Xing M, Wu Y, Li W, et al. Induction of neutrophil apoptosis by a Bcl-2 inhibitor reduces particulate matter-induced lung inflammation. Aging (Albany NY). 2018;10:1415-1423 pubmed publisher
Mertens B, Cristina de Araujo Nogueira T, Topalis D, Stranska R, Snoeck R, Andrei G. Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice. Oncotarget. 2018;9:21978-22000 pubmed publisher
Wang H, Li Z, Niu J, Xu Y, Ma L, Lu A, et al. Antiviral effects of ferric ammonium citrate. Cell Discov. 2018;4:14 pubmed publisher
Li Q, Li D, Zhang X, Wan Q, Zhang W, Zheng M, et al. E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor. Immunity. 2018;48:258-270.e5 pubmed publisher
Guo X, Chu L, Ke F, Mu L, Li Z, Cai J, et al. Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells. Oncotarget. 2017;8:108981-108988 pubmed publisher
Quach D, Collins F, Parameswaran N, McCabe L, Britton R. Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice. mSphere. 2018;3: pubmed publisher
Shim D, Shin W, Yu S, Kim B, Ye S, Koppula S, et al. BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination. Sci Rep. 2017;7:15020 pubmed publisher
Qin Y, Wu L, Ouyang Y, Zhou P, Zhou H, Wang Y, et al. MiR-125a Is a critical modulator for neutrophil development. PLoS Genet. 2017;13:e1007027 pubmed publisher
Zhang B, Wang B, Cao S, Wang Y, Wu D. Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-?B signaling and NLRP3 activation. Int J Mol Med. 2017;39:1111-1118 pubmed publisher
Piao Z, Yuan H, Wang C, Shi L. IRF3 Inhibits Neutrophil Recruitment in Mice Infected with Pseudomonas aeruginosa. Inflammation. 2017;40:735-744 pubmed publisher
Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed publisher
Di Siena S, Gimmelli R, Nori S, Barbagallo F, Campolo F, Dolci S, et al. Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury. Cell Death Dis. 2016;7:e2317 pubmed publisher
Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel M, et al. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016;7:292-305 pubmed publisher
Ben Shoshan S, Kagan P, Sultan M, Barabash Z, Dor C, Jacob Hirsch J, et al. ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis. RNA Biol. 2017;14:587-602 pubmed publisher
Zheng H, Zou W, Shen J, Xu L, Wang S, Fu Y, et al. Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth. Stem Cells Transl Med. 2016;5:1216-28 pubmed publisher
Xu Y, Liu Y, Yang C, Kang L, Wang M, Hu J, et al. Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses. Immunology. 2016;149:157-71 pubmed publisher
Mian Y, Zeleznik Le N. The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1. Leuk Res. 2016;46:51-60 pubmed publisher
Wang J, De Veirman K, Faict S, Frassanito M, Ribatti D, Vacca A, et al. Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression. J Pathol. 2016;239:162-73 pubmed publisher
Leist S, Pilzner C, van den Brand J, Dengler L, Geffers R, Kuiken T, et al. Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice. BMC Genomics. 2016;17:143 pubmed publisher
Vegas A, Veiseh O, Doloff J, Ma M, Tam H, Bratlie K, et al. Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016;34:345-52 pubmed publisher
Wang J, De Veirman K, De Beule N, Maes K, De Bruyne E, Van Valckenborgh E, et al. The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells. Oncotarget. 2015;6:43992-4004 pubmed publisher
Matthews G, Mehdipour P, Cluse L, Falkenberg K, Wang E, Roth M, et al. Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies. Blood. 2015;126:2392-403 pubmed publisher
Abboud D, Daubeuf F, Do Q, Utard V, Villa P, Haiech J, et al. A strategy to discover decoy chemokine ligands with an anti-inflammatory activity. Sci Rep. 2015;5:14746 pubmed publisher
Neri T, Muggeo S, Paulis M, Caldana M, Crisafulli L, Strina D, et al. Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts. Stem Cell Reports. 2015;5:558-68 pubmed publisher
Keswani R, Yoon G, Sud S, Stringer K, Rosania G. A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages. Cytometry A. 2015;87:855-67 pubmed publisher
Huang L, Kong Y, Wang J, Sun J, Shi Q, Qiu Y. Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway. Mol Med Rep. 2015;12:4187-4195 pubmed publisher
Draghiciu O, Nijman H, Hoogeboom B, Meijerhof T, Daemen T. Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication. Oncoimmunology. 2015;4:e989764 pubmed
Szulzewsky F, Pelz A, Feng X, Synowitz M, Markovic D, Langmann T, et al. Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PLoS ONE. 2015;10:e0116644 pubmed publisher
Castellana D, Paus R, Perez Moreno M. Macrophages contribute to the cyclic activation of adult hair follicle stem cells. PLoS Biol. 2014;12:e1002002 pubmed publisher
Deng L, Song J, Gao X, Wang J, Yu H, Chen X, et al. Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Cell. 2014;159:1290-9 pubmed publisher
Hari A, Zhang Y, Tu Z, Detampel P, Stenner M, Ganguly A, et al. Activation of NLRP3 inflammasome by crystalline structures via cell surface contact. Sci Rep. 2014;4:7281 pubmed publisher
Anderson E, Kwee B, Lewin S, Raimondo T, Mehta M, Mooney D. Local delivery of VEGF and SDF enhances endothelial progenitor cell recruitment and resultant recovery from ischemia. Tissue Eng Part A. 2015;21:1217-27 pubmed publisher
Doloff J, Chen C, Waxman D. Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2. Mol Cancer. 2014;13:158 pubmed publisher
Zamanian Daryoush M, Lindner D, Tallant T, Wang Z, Buffa J, Klipfell E, et al. The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects. J Biol Chem. 2013;288:21237-52 pubmed publisher
Patil S, Gentschev I, Adelfinger M, Donat U, Hess M, Weibel S, et al. Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody. PLoS ONE. 2012;7:e47472 pubmed publisher
Pello O, Chevre R, Laoui D, De Juan A, Lolo F, Andrés Manzano M, et al. In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities. PLoS ONE. 2012;7:e45399 pubmed publisher
Rajasekaran D, Keeler C, Syed M, Jones M, Harrison J, Wu D, et al. A model of GAG/MIP-2/CXCR2 interfaces and its functional effects. Biochemistry. 2012;51:5642-54 pubmed
Hill R, Gouffon J, Saxton A, Su C. Differential gene expression in mice infected with distinct Toxoplasma strains. Infect Immun. 2012;80:968-74 pubmed publisher
Wan W, Lim J, Lionakis M, Rivollier A, McDermott D, Kelsall B, et al. Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice. Circ Res. 2011;109:374-81 pubmed publisher
Choi J, Curtis S, Roy D, Flesken Nikitin A, Nikitin A. Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency. Am J Pathol. 2010;177:2645-58 pubmed publisher
Durand E, Maldonado Arocho F, Castillo C, Walsh R, Mecsas J. The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection. Cell Microbiol. 2010;12:1064-82 pubmed publisher
Drage M, Pecora N, Hise A, Febbraio M, Silverstein R, Golenbock D, et al. TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. Cell Immunol. 2009;258:29-37 pubmed publisher
Dupré S, Redelman D, Hunter K. The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci. Int J Exp Pathol. 2007;88:351-60 pubmed
Huang B, Zhao J, Shen S, Li H, He K, Shen G, et al. Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Res. 2007;67:4346-52 pubmed
Sasmono R, Ehrnsperger A, Cronau S, Ravasi T, Kandane R, Hickey M, et al. Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. J Leukoc Biol. 2007;82:111-23 pubmed
Fan J, Li Y, Vodovotz Y, Billiar T, Wilson M. Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2006;290:L738-L746 pubmed
Alvarez M, Prada F, Salvatierra E, Bravo A, Lutzky V, Carbone C, et al. Secreted protein acidic and rich in cysteine produced by human melanoma cells modulates polymorphonuclear leukocyte recruitment and antitumor cytotoxic capacity. Cancer Res. 2005;65:5123-32 pubmed
Brown C, Blaho V, Loiacono C. Susceptibility to experimental Lyme arthritis correlates with KC and monocyte chemoattractant protein-1 production in joints and requires neutrophil recruitment via CXCR2. J Immunol. 2003;171:893-901 pubmed
Miura M, Fu X, Zhang Q, Remick D, Fairchild R. Neutralization of Gro alpha and macrophage inflammatory protein-2 attenuates renal ischemia/reperfusion injury. Am J Pathol. 2001;159:2137-45 pubmed
Dunussi Joannopoulos K, Runyon K, Erickson J, Schaub R, Hawley R, Leonard J. Vaccines with interleukin-12-transduced acute myeloid leukemia cells elicit very potent therapeutic and long-lasting protective immunity. Blood. 1999;94:4263-73 pubmed
Fleming T, Fleming M, Malek T. Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. J Immunol. 1993;151:2399-408 pubmed
product information
Product Type :
Antibody
Product Name :
Ly-6G/Ly-6C Monoclonal Antibody (RB6-8C5), PE-eFluor 610, eBioscience™
Catalog # :
61-5931-80
Quantity :
25 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.06 µg/test
Species :
Mouse
Clone :
RB6-8C5
Isotype :
IgG2b, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Granulocytes are a category of white blood cells characterised by the presence of granules in their cytoplasm. They are also called polymorphonuclear leukocytes (PMN or PML) because of the varying shapes of the nucleus, which is usually lobed into three segments. In common parlance, the term polymorphonuclear leukocyte often refers specifically to neutrophil granulocytes, the most abundant of the granulocytes. Granulocytes or PMN are released from the bone marrow by the regulatory complement proteins.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.06 µg/test
Aliases :
AA682074; AA959465; Gr1; Gr-1; Granulocyte Marker; Ly6c; Ly-6C; Ly-6C.2; Ly6c1; Ly-6C1; Ly6c2; Ly-6C2; Ly6g; Ly-6G; ly-6G.1; lymphocyte antigen 6 complex, locus C; lymphocyte antigen 6 complex, locus C1; lymphocyte antigen 6 complex, locus C2; lymphocyte antigen 6 complex, locus G; lymphocyte antigen 6C precursor (Ly-6C); lymphocyte antigen 6C1; Lymphocyte antigen 6C2; lymphocyte antigen 6G; Lymphocyte antigen Ly-6C; lymphocyte differentiation antigen; PML; PMN
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA