This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
FOXP3 Monoclonal Antibody (PCH101), PE-eFluor 610, eBioscience
catalog :
61-4776-41
quantity :
25 Tests
price :
US 201.00
clonality :
monoclonal
host :
rat
conjugate :
PE-eFluor 610
clone name :
PCH101
reactivity :
crab eating macaque, human, chimpanzee, rhesus macaque
application :
flow cytometry
citations: 50
Reference
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Cascone T, Leung C, Weissferdt A, Pataer A, Carter B, Godoy M, et al. Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial. Nat Med. 2023;29:593-604 pubmed publisher
Liang Y, Li X, Yang Y, Xiao L, Liang Y, Mi J, et al. Preventive effects of Mycobacterium tuberculosis DNA vaccines on the mouse model with latent tuberculosis infection. Front Immunol. 2023;14:1110843 pubmed publisher
Babl N, Hofbauer J, Matos C, Voll F, Menevse A, Rechenmacher M, et al. Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model. Front Oncol. 2023;13:1107484 pubmed publisher
Ringelstein Harlev S, Fanadka M, Horowitz N, Bettman N, Katz T. In chronic lymphocytic leukemia, activation of the thrombopoietin receptor promotes T-cell inhibitory properties, contributing to immunosuppression. Eur J Haematol. 2023;110:371-378 pubmed publisher
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Wang W, Wang X, Lu S, Lv H, Zhao T, Xie G, et al. Metabolic Disturbance and Th17/Treg Imbalance Are Associated With Progression of Gingivitis. Front Immunol. 2021;12:670178 pubmed publisher
You Y, Huang S, Liu H, Fan C, Liu K, Wang Z. Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function. Mol Med Rep. 2021;24: pubmed publisher
Singh Y, Trautwein C, Fendel R, Krickeberg N, Berezhnoy G, Bissinger R, et al. SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells. Heliyon. 2021;7:e07147 pubmed publisher
Chang G, Yang X, Liu W, Lin S, Yang S, Zhao M. FABP4 facilitates inflammasome activation to induce the Treg/Th17 imbalance in preeclampsia via forming a positive feedback with IL-17A. Mol Ther Nucleic Acids. 2021;24:743-754 pubmed publisher
Thome A, Atassi F, Wang J, Faridar A, Zhao W, Thonhoff J, et al. Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson's disease. NPJ Parkinsons Dis. 2021;7:41 pubmed publisher
Li W, Luo Y, Xu H, Ma Q, Yao Q. Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice. J Int Med Res. 2021;49:300060521998471 pubmed publisher
Li S, Simoni Y, Becht E, Loh C, Li N, LaChance D, et al. Human Tumor-Infiltrating MAIT Cells Display Hallmarks of Bacterial Antigen Recognition in Colorectal Cancer. Cell Rep Med. 2020;1:100039 pubmed publisher
Gaudreau P, Negrao M, Mitchell K, Reuben A, Corsini E, Li J, et al. Neoadjuvant Chemotherapy Increases Cytotoxic T Cell, Tissue Resident Memory T Cell, and B Cell Infiltration in Resectable NSCLC. J Thorac Oncol. 2021;16:127-139 pubmed publisher
Harb H, Stephen Victor E, Crestani E, Benamar M, Massoud A, Cui Y, et al. A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2020;21:1359-1370 pubmed publisher
Kim Y, Park S, Ha H, Lee A, Won H, Cha H, et al. HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment. J Cancer. 2020;11:4059-4072 pubmed publisher
Henderson L, Hoyt K, Lee P, Rao D, Jonsson A, Nguyen J, et al. Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. JCI Insight. 2020;5: pubmed publisher
Rackaityte E, Halkias J, Fukui E, Mendoza V, Hayzelden C, Crawford E, et al. Viable bacterial colonization is highly limited in the human intestine in utero. Nat Med. 2020;26:599-607 pubmed publisher
Tian D, Yang L, Wang S, Zhu Y, Shi W, Zhang C, et al. Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma. Nat Commun. 2019;10:4246 pubmed publisher
Yang X, Zeng Q, Göktaş E, Gopal K, Al Aswad L, Blumberg D, et al. T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma. Invest Ophthalmol Vis Sci. 2019;60:877-888 pubmed publisher
Hu Y, Qi W, Sun L, Zhou H, Zhou B, Yang Z. Effect of TGF-β1 on blood CD4+CD25high regulatory T cell proliferation and Foxp3 expression during non-small cell lung cancer blood metastasis. Exp Ther Med. 2018;16:1403-1410 pubmed publisher
Arce Vargas F, Furness A, Litchfield K, Joshi K, Rosenthal R, Ghorani E, et al. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies. Cancer Cell. 2018;33:649-663.e4 pubmed publisher
Hsieh W, Hsu T, Chang Y, Lai M. IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nat Commun. 2018;9:463 pubmed publisher
Terranova Barberio M, Thomas S, Ali N, Pawlowska N, Park J, Krings G, et al. HDAC inhibition potentiates immunotherapy in triple negative breast cancer. Oncotarget. 2017;8:114156-114172 pubmed publisher
Khouri I, Fernandez Curbelo I, Turturro F, Jabbour E, Milton D, Bassett R, et al. Ipilimumab plus Lenalidomide after Allogeneic and Autologous Stem Cell Transplantation for Patients with Lymphoid Malignancies. Clin Cancer Res. 2018;24:1011-1018 pubmed publisher
Sha J, Liu F, Zhai J, Liu X, Zhang Q, Zhang B. Alteration of Th17 and Foxp3+ regulatory T cells in patients with unexplained recurrent spontaneous abortion before and after the therapy of hCG combined with immunoglobulin. Exp Ther Med. 2017;14:1114-1118 pubmed publisher
McDonnell A, Cook A, Robinson B, Lake R, Nowak A. Serial immunomonitoring of cancer patients receiving combined antagonistic anti-CD40 and chemotherapy reveals consistent and cyclical modulation of T cell and dendritic cell parameters. BMC Cancer. 2017;17:417 pubmed publisher
Miller S, Miles B, Guo K, Folkvord J, Meditz A, McCarter M, et al. Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1. J Virol. 2017;91: pubmed publisher
Su S, Liao J, Liu J, Huang D, He C, Chen F, et al. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017;27:461-482 pubmed publisher
Clever D, Roychoudhuri R, Constantinides M, Askenase M, Sukumar M, Klebanoff C, et al. Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche. Cell. 2016;166:1117-1131.e14 pubmed publisher
Zhao J, Ma J, Zhang X, Li Q, Yang X. Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance. Exp Ther Med. 2016;11:2300-2304 pubmed
Vieira A, Trindade M, Pagliari C, Avancini J, Sakai Valente N, Duarte A, et al. Development of Type 2, But Not Type 1, Leprosy Reactions is Associated with a Severe Reduction of Circulating and In situ Regulatory T-Cells. Am J Trop Med Hyg. 2016;94:721-7 pubmed publisher
Younis R, Han K, Webb T. Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells. J Immunol. 2016;196:1419-29 pubmed publisher
Sakthivel P, Grunewald J, Eklund A, Bruder D, Wahlström J. Pulmonary sarcoidosis is associated with high-level inducible co-stimulator (ICOS) expression on lung regulatory T cells--possible implications for the ICOS/ICOS-ligand axis in disease course and resolution. Clin Exp Immunol. 2016;183:294-306 pubmed publisher
De Rosa V, Galgani M, Porcellini A, Colamatteo A, Santopaolo M, Zuchegna C, et al. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants. Nat Immunol. 2015;16:1174-84 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
FOXP3 Monoclonal Antibody (PCH101), PE-eFluor 610, eBioscience
Catalog # :
61-4776-41
Quantity :
25 Tests
Price :
US 201.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Chimpanzee, Cynomolgus Monkey, Human, Non-human primate, Rhesus Monkey
Applications :
Flow Cytometry: 5 uL (0.25 ug)/test
Species :
Chimpanzee, Cynomolgus Monkey, Human, Non-human primate, Rhesus Monkey
Clone :
PCH101
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.25 ug)/test
Aliases :
AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA