product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD19 Monoclonal Antibody (eBio1D3 (1D3)), PE-eFluor 610, eBioscience™
catalog :
61-0193-82
quantity :
100 µg
price :
US 309.00
clonality :
monoclonal
host :
rat
conjugate :
PE-eFluor 610
clone name :
eBio1D3 (1D3)
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 37
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig S3
Uhde A, Herder V, Akram Khan M, Ciurkiewicz M, Schaudien D, Teich R, et al. Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice. PLoS ONE. 2016;11:e0161883 pubmed publisher
Chandran S, Schilke R, Blackburn C, Yurochko A, Mirza R, Scott R, et al. Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization. Front Immunol. 2020;11:787 pubmed publisher
Goldstein J, Valido A, Lewandowski J, Walker R, Mills M, Messemer K, et al. Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus. Sci Rep. 2019;9:18613 pubmed publisher
Gautam A, Park B, Kim T, Akauliya M, Kim D, Maharjan S, et al. Peritoneal Cells Mediate Immune Responses and Cross-Protection Against Influenza A Virus. Front Immunol. 2019;10:1160 pubmed publisher
Weng Q, Hu F, Zhang M, Dong Y, Lv C, Wang Y, et al. A protocol for generating induced T cells by reprogramming B cells in vivo. Cell Regen (Lond). 2018;7:7-15 pubmed publisher
Sarkar A, Shukla S, Alqatawni A, Kumar A, Addya S, Tsygankov A, et al. The Role of Allograft Inflammatory Factor-1 in the Effects of Experimental Diabetes on B Cell Functions in the Heart. Front Cardiovasc Med. 2018;5:126 pubmed publisher
Moretti F, Klapproth S, Ruppert R, Margraf A, Weber J, Pick R, et al. Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus. elife. 2018;7: pubmed publisher
Uhde A, Ciurkiewicz M, Herder V, Khan M, Hensel N, Claus P, et al. Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice. Sci Rep. 2018;8:6106 pubmed publisher
Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, et al. Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun. 2018;9:1136 pubmed publisher
Kauts M, Rodríguez Seoane C, Kaimakis P, Mendes S, Cortés Lavaud X, Hill U, et al. In Vitro Differentiation of Gata2 and Ly6a Reporter Embryonic Stem Cells Corresponds to In Vivo Waves of Hematopoietic Cell Generation. Stem Cell Reports. 2018;10:151-165 pubmed publisher
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, et al. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018;172:517-533.e20 pubmed publisher
Bai W, Li C, Zhang C, Xu L, Zeng Q, Hu B, et al. Prolonged Deleterious Influences of Chemotherapeutic Agent CPT-11 on Resident Peritoneal Macrophages and B1 Cells. Front Immunol. 2017;8:1919 pubmed publisher
Wang Y, Xiao M, Tao C, Chen J, Wang Z, Yang J, et al. Inactivation of mTORC1 Signaling in Osterix-expressing Cells Impairs B-cell Differentiation. J Bone Miner Res. 2017;: pubmed publisher
Deng R, Hurtz C, Song Q, Yue C, Xiao G, Yu H, et al. Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease. Nat Commun. 2017;8:978 pubmed publisher
Chang A, Dao T, Gejman R, Jarvis C, Scott A, Dubrovsky L, et al. A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens. J Clin Invest. 2017;127:2705-2718 pubmed publisher
Wagner J, Jaurich H, Wallner C, Abraham S, Becerikli M, Dadras M, et al. Diminished bone regeneration after debridement of posttraumatic osteomyelitis is accompanied by altered cytokine levels, elevated B cell activity, and increased osteoclast activity. J Orthop Res. 2017;35:2425-2434 pubmed publisher
Grodeland G, Fredriksen A, Løset G, Vikse E, Fugger L, Bogen B. Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination. J Immunol. 2016;197:3575-3585 pubmed
Xiong J, Zhou M, Wang Y, Chen L, Xu W, Wang Y, et al. Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice. Sci Rep. 2016;6:34079 pubmed publisher
Jacoby E, Nguyen S, Fountaine T, Welp K, Gryder B, Qin H, et al. CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity. Nat Commun. 2016;7:12320 pubmed publisher
Gravano D, Al Kuhlani M, Davini D, Sanders P, Manilay J, Hoyer K. CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure. J Autoimmun. 2016;75:58-67 pubmed publisher
Ben Shoshan S, Kagan P, Sultan M, Barabash Z, Dor C, Jacob Hirsch J, et al. ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis. RNA Biol. 2017;14:587-602 pubmed publisher
Dou D, Calvanese V, Sierra M, Nguyen A, Minasian A, Saarikoski P, et al. Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol. 2016;18:595-606 pubmed publisher
Kourtidis A, Anastasiadis P. PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications. Cell Cycle. 2016;15:498-505 pubmed publisher
Weiss J, Robinet M, Aricha R, Cufi P, Villeret B, Lantner F, et al. Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis. Oncotarget. 2016;7:7550-62 pubmed publisher
Pylayeva Gupta Y, Das S, Handler J, Hajdu C, Coffre M, Koralov S, et al. IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia. Cancer Discov. 2016;6:247-55 pubmed publisher
Johnson K, Kong G, Gao X, Chang Y, Hewitt K, Sanalkumar R, et al. Cis-regulatory mechanisms governing stem and progenitor cell transitions. Sci Adv. 2015;1:e1500503 pubmed publisher
Lim S, Kim W, Kim Y, Lee S, Koo J, Lee J, et al. dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis. Nat Commun. 2015;6:8244 pubmed publisher
Song N, Gao L, Qiu H, Huang C, Cheng H, Zhou H, et al. Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant. Int J Mol Med. 2015;36:139-49 pubmed publisher
Pone E, Lam T, Lou Z, Wang R, Chen Y, Liu D, et al. B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. J Immunol. 2015;194:3065-78 pubmed publisher
Tran C, Stary C, Schilling J, Bentley B, Patel H, Roth D. Role of caveolin-3 in lymphocyte activation. Life Sci. 2015;121:35-9 pubmed publisher
Yu M, Chen Y, He Y, Podd A, Fu G, Wright J, et al. Critical role of B cell lymphoma 10 in BAFF-regulated NF-?B activation and survival of anergic B cells. J Immunol. 2012;189:5185-93 pubmed publisher
Phadwal K, Alegre Abarrategui J, Watson A, Pike L, Anbalagan S, Hammond E, et al. A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells. Autophagy. 2012;8:677-89 pubmed publisher
Shoham T, Rajapaksa R, Boucheix C, Rubinstein E, Poe J, Tedder T, et al. The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. J Immunol. 2003;171:4062-72 pubmed
Inabe K, Kurosaki T. Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement. Blood. 2002;99:584-9 pubmed
Cherukuri A, Cheng P, Pierce S. The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens. J Immunol. 2001;167:163-72 pubmed
Krop I, Shaffer A, Fearon D, Schlissel M. The signaling activity of murine CD19 is regulated during cell development. J Immunol. 1996;157:48-56 pubmed
Krop I, de Fougerolles A, Hardy R, Allison M, Schlissel M, Fearon D. Self-renewal of B-1 lymphocytes is dependent on CD19. Eur J Immunol. 1996;26:238-42 pubmed
product information
Product Type :
Antibody
Product Name :
CD19 Monoclonal Antibody (eBio1D3 (1D3)), PE-eFluor 610, eBioscience™
Catalog # :
61-0193-82
Quantity :
100 µg
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test
Species :
Mouse
Clone :
eBio1D3 (1D3)
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains. CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test
Aliases :
AW495831; B4; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Cd19; CD19 antigen; CD19 molecule; CVID3; differentiation antigen CD19; Leu-12; T-cell surface antigen Leu-12
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA