CD223 (LAG-3) Monoclonal Antibody (3DS223H), Alexa Fluor 700, eBioscience | Invitrogen 56-2239-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD223 (LAG-3) Monoclonal Antibody (3DS223H), Alexa Fluor 700, eBioscience

catalog :

56-2239-42

quantity :

100 Tests

price :

US 451.00

clonality :

monoclonal

host :

mouse

conjugate :

AF700

clone name :

3DS223H

reactivity :

human

application :

flow cytometry

citations: 7

Reference
Yu T, Nie F, Zhang Q, Yu S, Zhang M, Wang Q, et al. Effects of methionine deficiency on B7H3-DAP12-CAR-T cells in the treatment of lung squamous cell carcinoma. Cell Death Dis. 2024;15:12 pubmed publisher
Babl N, Hofbauer J, Matos C, Voll F, Menevse A, Rechenmacher M, et al. Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model. Front Oncol. 2023;13:1107484 pubmed publisher
YEKU O, Rao T, Laster I, Kononenko A, Purdon T, Wang P, et al. Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition. Front Immunol. 2021;12:663379 pubmed publisher
Choe J, Watchmaker P, Simic M, Gilbert R, Li A, Krasnow N, et al. SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Sci Transl Med. 2021;13: pubmed publisher
Stunnenberg M, van Pul L, Sprokholt J, van Dort K, Gringhuis S, Geijtenbeek T, et al. MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals. Viruses. 2020;12: pubmed publisher
Hegde M, Joseph S, Pashankar F, Derenzo C, Sanber K, Navai S, et al. Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma. Nat Commun. 2020;11:3549 pubmed publisher
Anzengruber F, Ignatova D, Schlaepfer T, Chang Y, French L, Pascolo S, et al. Divergent LAG-3 versus BTLA, TIGIT, and FCRL3 expression in Sézary syndrome. Leuk Lymphoma. 2019;60:1899-1907 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD223 (LAG-3) Monoclonal Antibody (3DS223H), Alexa Fluor 700, eBioscience

Catalog # :

56-2239-42

Quantity :

100 Tests

Price :

US 451.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.06 ug)/test

Species :

Human

Clone :

3DS223H

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4. LAG-3 binds to MHC class II with higher affinity than CD4 and is thought to be involved in the negative regulation of T cell activation and homeostatic proliferation. Surface expression of LAG-3 has been reported on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells usually express LAG-3 at significantly higher levels than CD4+ T cells. Coexpression of LAG-3 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells).

Immunogen :

hCD223-FC PFA 4%

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.06 ug)/test

Aliases :

Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3