product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD8a Monoclonal Antibody (RPA-T8), Alexa Fluor 700, eBioscience
catalog :
56-0088-41
quantity :
25 Tests
price :
US 124.00
clonality :
monoclonal
host :
mouse
conjugate :
AF700
clone name :
RPA-T8
reactivity :
human, mouse
application :
flow cytometry
more info or order :
citations: 113
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 3b
Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed publisher
  • flow cytometry; human; fig 4
Owens G, Erickson K, Malone C, Pan C, Huynh M, Chang J, et al. Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis. J Neuroinflammation. 2015;12:134 pubmed publisher
  • flow cytometry; mouse; fig 3
Markley J, Sadelain M. IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice. Blood. 2010;115:3508-19 pubmed publisher
Kaiser J, Nelson C, Liu X, Park H, Matsuoka Y, Luongo C, et al. Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques. Nat Commun. 2024;15:3553 pubmed publisher
Swatler J, Targo x144 ska A, Turos Korgul L, Mosieniak G, Piwocka K. Protocol for isolation of tumor-derived extracellular vesicles and functional studies on human T cell subsets. STAR Protoc. 2024;5:103011 pubmed publisher
Abdala Torres T, Campi Azevedo A, da Silva Pereira R, Dos Santos L, Henriques P, Costa Rocha I, et al. Immune response induced by standard and fractional doses of 17DD yellow fever vaccine. NPJ Vaccines. 2024;9:54 pubmed publisher
Van Den Eeckhout B, Ballegeer M, De Clercq J, Burg E, Saelens X, Vandekerckhove L, et al. Rethinking IL-1 Antagonism in Respiratory Viral Infections: A Role for IL-1 Signaling in the Development of Antiviral T Cell Immunity. Int J Mol Sci. 2023;24: pubmed publisher
Chan W, Cao Y, Zhao X, Schrom E, Jia D, Song J, et al. TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways. J Exp Med. 2023;220: pubmed publisher
Li D, Zhou X, Xu W, Chen Y, Mu C, Zhao X, et al. Prostate cancer cells synergistically defend against CD8+ T cells by secreting exosomal PD-L1. Cancer Med. 2023;12:16405-16415 pubmed publisher
Zhang Y, Luo F, Dong K. Soluble NKG2D ligands impair CD8+ T cell antitumor function dependent of NKG2D downregulation in neuroblastoma. Oncol Lett. 2023;26:297 pubmed publisher
Lu T, Zhang J, Lu S, Yang F, Gan L, Wu X, et al. Endosialin-positive tumor-derived pericytes promote tumor progression through impeding the infiltration of CD8+ T cells in clear cell renal cell carcinoma. Cancer Immunol Immunother. 2023;72:1739-1750 pubmed publisher
Tan D, An J, Gong M, Wang H, Li H, Meng H, et al. Screening of an individualized treatment strategy for an advanced gallbladder cancer using patient-derived tumor xenograft and organoid models. Front Oncol. 2022;12:1043479 pubmed publisher
Li Q, Zhang L, You W, Xu J, Dai J, Hua D, et al. PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells. Nat Commun. 2022;13:7677 pubmed publisher
Li J, Huang D, Lei B, Huang J, Yang L, Nie M, et al. VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis. elife. 2022;11: pubmed publisher
Yu Z, Li G, Yu H, Asakawa T. Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study. Open Life Sci. 2021;16:1002-1009 pubmed publisher
Vardam Kaur T, Pathangey L, McCormick D, Bergsagel P, Cohen P, Gendler S. Multipeptide stimulated PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma. Oncotarget. 2021;12:2051-2067 pubmed publisher
Cole B, Lambrechts L, Gantner P, Noppe Y, Bonine N, Witkowski W, et al. In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia. Nat Commun. 2021;12:3727 pubmed publisher
Renner K, Schwittay T, Chaabane S, Gottschling J, Muller C, Tiefenböck C, et al. Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes. Nat Commun. 2021;12:3006 pubmed publisher
Zhong L, Shi W, Gan L, Liu X, Huo Y, Wu P, et al. Human endoglin-CD3 bispecific T cell engager antibody induces anti-tumor effect in vivo. Theranostics. 2021;11:6393-6406 pubmed publisher
Thome A, Atassi F, Wang J, Faridar A, Zhao W, Thonhoff J, et al. Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson's disease. NPJ Parkinsons Dis. 2021;7:41 pubmed publisher
YEKU O, Rao T, Laster I, Kononenko A, Purdon T, Wang P, et al. Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition. Front Immunol. 2021;12:663379 pubmed publisher
Festag J, Thelemann T, Schell M, Raith S, Michel S, Jaschinski F, et al. Preventing ATP Degradation by ASO-Mediated Knockdown of CD39 and CD73 Results in A2aR-Independent Rescue of T Cell Proliferation. Mol Ther Nucleic Acids. 2020;21:656-669 pubmed publisher
Hammill J, Kwiecien J, Dvorkin Gheva A, Lau V, Baker C, Wu Y, et al. A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity. Mol Ther Oncolytics. 2020;17:278-292 pubmed publisher
Jarrell J, Twite A, Lau K, Kashani M, Lievano A, Acevedo J, et al. Intracellular delivery of mRNA to human primary T cells with microfluidic vortex shedding. Sci Rep. 2019;9:3214 pubmed publisher
Lagou V, Garcia Perez J, Smets I, Van Horebeek L, Vandebergh M, Chen L, et al. Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators. Cell Rep. 2018;25:798-810.e6 pubmed publisher
Fujii S, Yoshida S, Inagaki E, Hatou S, Tsubota K, Takahashi M, et al. Immunological properties of neural crest cells derived from human induced pluripotent stem cells. Stem Cells Dev. 2018;: pubmed publisher
Sugita S, Makabe K, Fujii S, Iwasaki Y, Kamao H, Shiina T, et al. Detection of Retinal Pigment Epithelium-Specific Antibody in iPSC-Derived Retinal Pigment Epithelium Transplantation Models. Stem Cell Reports. 2017;9:1501-1515 pubmed publisher
Su S, Liao J, Liu J, Huang D, He C, Chen F, et al. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017;27:461-482 pubmed publisher
Chen J, Wang Q, Feng X, Zhang Z, Geng L, Xu T, et al. Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria. Stem Cells Int. 2016;2016:4062789 pubmed publisher
Miles B, Miller S, Folkvord J, Levy D, Rakasz E, Skinner P, et al. Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection. PLoS Pathog. 2016;12:e1005924 pubmed publisher
Sugita S, Iwasaki Y, Makabe K, Kimura T, Futagami T, Suegami S, et al. Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors. Stem Cell Reports. 2016;7:619-634 pubmed publisher
Tang Z, Hao Y, Zhang E, Xu C, Zhou Y, Zheng X, et al. CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade. Mol Med Rep. 2016;14:1107-16 pubmed publisher
Younis R, Han K, Webb T. Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells. J Immunol. 2016;196:1419-29 pubmed publisher
Jozwik A, Habibi M, Paras A, Zhu J, Guvenel A, Dhariwal J, et al. RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection. Nat Commun. 2015;6:10224 pubmed publisher
Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed publisher
Biylgi O, Karagöz B, Türken O, Gültepe M, Özgün A, Tunçel T, et al. CD4+CD25(high), CD8+CD28- cells and thyroid autoantibodies in breast cancer patients. Cent Eur J Immunol. 2014;39:338-44 pubmed publisher
Ly J, Lagman M, Saing T, Singh M, Tudela E, Morris D, et al. Liposomal Glutathione Supplementation Restores TH1 Cytokine Response to Mycobacterium tuberculosis Infection in HIV-Infected Individuals. J Interferon Cytokine Res. 2015;35:875-87 pubmed publisher
Lagman M, Ly J, Saing T, Kaur Singh M, Vera Tudela E, Morris D, et al. Investigating the causes for decreased levels of glutathione in individuals with type II diabetes. PLoS ONE. 2015;10:e0118436 pubmed publisher
Butcher L, Garcia M, Arnold M, Ueno H, Goel A, Boland C. Immune response to JC virus T antigen in patients with and without colorectal neoplasia. Gut Microbes. 2014;5:468-75 pubmed publisher
Feuth T, van Baarle D, van Erpecum K, Siersema P, Hoepelman A, Arends J. CD4/CD8 ratio is a promising candidate for non-invasive measurement of liver fibrosis in chronic HCV-monoinfected patients. Eur J Clin Microbiol Infect Dis. 2014;33:1113-7 pubmed publisher
Wittenbecher F, Rieger K, Dziubianau M, Herholz A, Mensen A, Blau I, et al. Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease. Leuk Res Rep. 2013;2:82-5 pubmed publisher
Fujiyuki T, Yoneda M, Yasui F, Kuraishi T, Hattori S, Kwon H, et al. Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1). PLoS ONE. 2013;8:e83551 pubmed publisher
Fernandes C, Gonçalves H, Cabral P, Pinto H, Pinto M, Câmara L. Increased frequency of CD4 and CD8 regulatory T cells in individuals under 15 years with multibacillary leprosy. PLoS ONE. 2013;8:e79072 pubmed publisher
Abbott R, Quinn L, Leese A, Scholes H, Pachnio A, Rickinson A. CD8+ T cell responses to lytic EBV infection: late antigen specificities as subdominant components of the total response. J Immunol. 2013;191:5398-409 pubmed publisher
Sena A, Grishina I, Thai A, Goulart L, Macal M, Fenton A, et al. Dysregulation of anti-inflammatory annexin A1 expression in progressive Crohns Disease. PLoS ONE. 2013;8:e76969 pubmed publisher
Valentine M, Song K, Maresh G, Mack H, Huaman M, Polacino P, et al. Expression of the memory marker CD45RO on helper T cells in macaques. PLoS ONE. 2013;8:e73969 pubmed publisher
Derkow K, Bauer J, Hecker M, Paap B, Thamilarasan M, Koczan D, et al. Multiple sclerosis: modulation of toll-like receptor (TLR) expression by interferon-? includes upregulation of TLR7 in plasmacytoid dendritic cells. PLoS ONE. 2013;8:e70626 pubmed publisher
Burns J, Song Y, Bujold M, Shimizu C, Kanegaye J, Tremoulet A, et al. Immune-monitoring in Kawasaki disease patients treated with infliximab and intravenous immunoglobulin. Clin Exp Immunol. 2013;174:337-44 pubmed publisher
Kshirsagar S, Binder E, Riedl M, Wechselberger G, Steichen E, Edelbauer M. Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. Arthritis Rheum. 2013;65:2996-3006 pubmed publisher
Yanagisawa K, Yue S, van der Vliet H, Wang R, Alatrakchi N, Golden Mason L, et al. Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C. J Viral Hepat. 2013;20:556-65 pubmed publisher
Gooden M, Wiersma V, Samplonius D, Gerssen J, van Ginkel R, Nijman H, et al. Galectin-9 activates and expands human T-helper 1 cells. PLoS ONE. 2013;8:e65616 pubmed publisher
Danso Abeam D, Zhang J, Dooley J, Staats K, Van Eyck L, Van Brussel T, et al. Olmsted syndrome: exploration of the immunological phenotype. Orphanet J Rare Dis. 2013;8:79 pubmed publisher
Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, et al. 60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells. J Biol Chem. 2013;288:15537-46 pubmed publisher
Macdonald K, Han J, Himmel M, Huang Q, Kan B, Campbell A, et al. Response to comment on "helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans". J Immunol. 2013;190:4440-1 pubmed publisher
Feuth T, Arends J, Fransen J, Nanlohy N, van Erpecum K, Siersema P, et al. Complementary role of HCV and HIV in T-cell activation and exhaustion in HIV/HCV coinfection. PLoS ONE. 2013;8:e59302 pubmed publisher
Canary L, Vinton C, Morcock D, Pierce J, Estes J, Brenchley J, et al. Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. J Immunol. 2013;190:2959-65 pubmed publisher
Azevedo R, Soares M, Albuquerque A, Tendeiro R, Soares R, Martins M, et al. Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19:703-12 pubmed publisher
Lin C, Kift Morgan A, Moser B, Topley N, Eberl M. Suppression of pro-inflammatory T-cell responses by human mesothelial cells. Nephrol Dial Transplant. 2013;28:1743-50 pubmed publisher
Cosgrove C, Ussher J, Rauch A, Gärtner K, Kurioka A, Hühn M, et al. Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood. 2013;121:951-61 pubmed publisher
Vinet J, van Zwam M, Dijkstra I, Brouwer N, van Weering H, Watts A, et al. Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR. Br J Pharmacol. 2013;168:1375-87 pubmed publisher
Müller J, Waldmann T, Kruhlak M, Dubois S. Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15R? in human monocytes and dendritic cells. J Biol Chem. 2012;287:40328-38 pubmed publisher
Ma C, Zhang Q, Ye J, Wang F, Zhang Y, Wevers E, et al. Tumor-infiltrating ?? T lymphocytes predict clinical outcome in human breast cancer. J Immunol. 2012;189:5029-36 pubmed publisher
Pellegrini F, Marinoni M, Frangione V, Tedeschi A, Gandini V, Ciglia F, et al. Down syndrome, autoimmunity and T regulatory cells. Clin Exp Immunol. 2012;169:238-43 pubmed publisher
Vargas Inchaustegui D, Xiao P, Tuero I, Patterson L, Robert Guroff M. NK and CD4+ T cell cooperative immune responses correlate with control of disease in a macaque simian immunodeficiency virus infection model. J Immunol. 2012;189:1878-85 pubmed publisher
Ramakrishnan S, Page A, Farris A, Singh K, Leopardi F, Hamby K, et al. Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques. Am J Transplant. 2012;12:1755-64 pubmed publisher
Kanai Y, Satoh T, Igawa K, Yokozeki H. Impaired expression of Tim-3 on Th17 and Th1 cells in psoriasis. Acta Derm Venereol. 2012;92:367-71 pubmed publisher
Gorska M, Alam R. A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia. Blood. 2012;119:1399-406 pubmed publisher
McAlpine S, Issekutz T, Marshall J. Virus stimulation of human mast cells results in the recruitment of CD56? T cells by a mechanism dependent on CCR5 ligands. FASEB J. 2012;26:1280-9 pubmed publisher
Hippen K, Bucher C, Schirm D, Bearl A, Brender T, Mink K, et al. Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes. Blood. 2012;119:619-28 pubmed publisher
Kean L, Sen S, Onabajo O, Singh K, Robertson J, Stempora L, et al. Significant mobilization of both conventional and regulatory T cells with AMD3100. Blood. 2011;118:6580-90 pubmed publisher
Klatt N, Vinton C, Lynch R, Canary L, Ho J, Darrah P, et al. SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination. Blood. 2011;118:5803-12 pubmed publisher
Page A, Srinivasan S, Singh K, Russell M, Hamby K, Deane T, et al. CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model. Am J Transplant. 2012;12:115-25 pubmed publisher
Kotturi M, Swann J, Peters B, Arlehamn C, Sidney J, Kolla R, et al. Human CD8? and CD4? T cell memory to lymphocytic choriomeningitis virus infection. J Virol. 2011;85:11770-80 pubmed publisher
Demberg T, Ettinger A, Aladi S, McKinnon K, Kuddo T, Venzon D, et al. Strong viremia control in vaccinated macaques does not prevent gradual Th17 cell loss from central memory. Vaccine. 2011;29:6017-28 pubmed publisher
Andorsky D, Yamada R, Said J, Pinkus G, Betting D, Timmerman J. Programmed death ligand 1 is expressed by non-hodgkin lymphomas and inhibits the activity of tumor-associated T cells. Clin Cancer Res. 2011;17:4232-44 pubmed publisher
Santos R, Lin K, Mansfield K, Wachtman L. Specific pathogen-free status alters immunophenotype in rhesus macaques: implications for the study of simian immunodeficiency virus. AIDS Res Hum Retroviruses. 2011;27:1033-42 pubmed publisher
Zhang Y, Li J, Lou J, Zhou Y, Bo L, Zhu J, et al. Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients. Crit Care. 2011;15:R70 pubmed publisher
Franco A, Almanza G, Burns J, Wheeler M, Zanetti M. Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones. Cell Immunol. 2010;266:1-6 pubmed publisher
Llanos Cuentas A, Calderon W, Cruz M, Ashman J, Alves F, Coler R, et al. A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with sodium stibogluconate for the treatment of mucosal leishmaniasis. Vaccine. 2010;28:7427-35 pubmed publisher
Meier D, Cagnola H, Ramisch D, Rumbo C, Chirdo F, Docena G, et al. Analysis of immune cells draining from the abdominal cavity as a novel tool to study intestinal transplant immunobiology. Clin Exp Immunol. 2010;162:138-45 pubmed publisher
Marwaha A, Crome S, Panagiotopoulos C, Berg K, Qin H, Ouyang Q, et al. Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J Immunol. 2010;185:3814-8 pubmed publisher
Rychert J, Strick D, Bazner S, Robinson J, Rosenberg E. Detection of HIV gp120 in plasma during early HIV infection is associated with increased proinflammatory and immunoregulatory cytokines. AIDS Res Hum Retroviruses. 2010;26:1139-45 pubmed publisher
De Meester J, Calvez R, Valitutti S, Dupré L. The Wiskott-Aldrich syndrome protein regulates CTL cytotoxicity and is required for efficient killing of B cell lymphoma targets. J Leukoc Biol. 2010;88:1031-40 pubmed publisher
Payne R, Kløverpris H, Sacha J, Brumme Z, Brumme C, Buus S, et al. Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cells. J Virol. 2010;84:10543-57 pubmed publisher
Harris L, Klatt N, Vinton C, Briant J, Tabb B, Ladell K, et al. Mechanisms underlying ?? T-cell subset perturbations in SIV-infected Asian rhesus macaques. Blood. 2010;116:4148-57 pubmed publisher
Lechner M, Liebertz D, Epstein A. Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. J Immunol. 2010;185:2273-84 pubmed publisher
Martin J, Perry J, Jakhete N, Wang X, Bielekova B. An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells. J Immunol. 2010;185:1311-20 pubmed publisher
Freeman C, Han M, Martinez F, Murray S, Liu L, Chensue S, et al. Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15. J Immunol. 2010;184:6504-13 pubmed publisher
Taaffe J, Chahroudi A, Engram J, Sumpter B, Meeker T, Ratcliffe S, et al. A five-year longitudinal analysis of sooty mangabeys naturally infected with simian immunodeficiency virus reveals a slow but progressive decline in CD4+ T-cell count whose magnitude is not predicted by viral load or immune activation. J Virol. 2010;84:5476-84 pubmed publisher
Franco A, Shimizu C, Tremoulet A, Burns J. Memory T-cells and characterization of peripheral T-cell clones in acute Kawasaki disease. Autoimmunity. 2010;43:317-24 pubmed publisher
Satoh T, Shimura C, Miyagishi C, Yokozeki H. Indomethacin-induced reduction in CRTH2 in eosinophilic pustular folliculitis (Ofuji's disease): a proposed mechanism of action. Acta Derm Venereol. 2010;90:18-22 pubmed publisher
Marino J, Tan C, Taylor A, Bentley C, Van De Wiele C, Ranne R, et al. Differential IL-7 responses in developing human thymocytes. Hum Immunol. 2010;71:329-33 pubmed publisher
Shimizu S, Hong P, Arumugam B, Pokomo L, Boyer J, Koizumi N, et al. A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood. 2010;115:1534-44 pubmed publisher
Brudek T, Christensen T, Aagaard L, Petersen T, Hansen H, Møller Larsen A. B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity. Retrovirology. 2009;6:104 pubmed publisher
Kvistborg P, Boegh M, Pedersen A, Claesson M, Zocca M. Fast generation of dendritic cells. Cell Immunol. 2009;260:56-62 pubmed publisher
Huarte E, Fisher J, Turk M, Mellinger D, Foster C, Wolf B, et al. Ex vivo expansion of tumor specific lymphocytes with IL-15 and IL-21 for adoptive immunotherapy in melanoma. Cancer Lett. 2009;285:80-8 pubmed publisher
Unsinger J, McDonough J, Shultz L, Ferguson T, Hotchkiss R. Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol. 2009;86:219-27 pubmed publisher
Yao Y, Tao R, Wang X, Wang Y, Mao Y, Zhou L. B7-H1 is correlated with malignancy-grade gliomas but is not expressed exclusively on tumor stem-like cells. Neuro Oncol. 2009;11:757-66 pubmed publisher
Shao L, Zhang W, Zhang S, Chen C, Jiang W, Xu Y, et al. Potent immune responses of Ag-specific Vgamma2Vdelta2+ T cells and CD8+ T cells associated with latent stage of Mycobacterium tuberculosis coinfection in HIV-1-infected humans. AIDS. 2008;22:2241-50 pubmed publisher
Fujimaki W, Takahashi N, Ohnuma K, Nagatsu M, Kurosawa H, Yoshida S, et al. Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood. Clin Dev Immunol. 2008;2008:305859 pubmed publisher
Taglauer E, Trikhacheva A, Slusser J, Petroff M. Expression and function of PDCD1 at the human maternal-fetal interface. Biol Reprod. 2008;79:562-9 pubmed publisher
Thakral D, Dobbins J, Devine L, Kavathas P. Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. J Immunol. 2008;180:7431-42 pubmed
Arimura Y, Vang T, Tautz L, Williams S, Mustelin T. TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses. Mol Immunol. 2008;45:3074-84 pubmed publisher
Estes J, Gordon S, Zeng M, Chahroudi A, Dunham R, Staprans S, et al. Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques. J Immunol. 2008;180:6798-807 pubmed
Chaitra M, Shaila M, Chandra N, Nayak R. HLA-A*0201-restricted cytotoxic T-cell epitopes in three PE/PPE family proteins of Mycobacterium tuberculosis. Scand J Immunol. 2008;67:411-7 pubmed publisher
Hartigan O Connor D, Abel K, McCune J. Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med. 2007;204:2679-92 pubmed
Pang D, Hayday A, Bijlmakers M. CD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers. J Biol Chem. 2007;282:13884-94 pubmed
Chen Y, Yang C, Jin N, Xie Z, Tang Y, Fei L, et al. Terminal complement complex C5b-9-treated human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization. Eur J Immunol. 2007;37:167-76 pubmed
Ishida T, Ishii T, Inagaki A, Yano H, Komatsu H, Iida S, et al. Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege. Cancer Res. 2006;66:5716-22 pubmed
Otsuki N, Kamimura Y, Hashiguchi M, Azuma M. Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells. Biochem Biophys Res Commun. 2006;344:1121-7 pubmed
Mansson A, Adner M, Cardell L. Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. Respir Res. 2006;7:36 pubmed
Chan S, Olson J, Utz P. Single-cell analysis of siRNA-mediated gene silencing using multiparameter flow cytometry. Cytometry A. 2006;69:59-65 pubmed
Giroux M, Denis F. CD1d-unrestricted human NKT cells release chemokines upon Fas engagement. Blood. 2005;105:703-10 pubmed
product information
Product Type :
Antibody
Product Name :
CD8a Monoclonal Antibody (RPA-T8), Alexa Fluor 700, eBioscience
Catalog # :
56-0088-41
Quantity :
25 Tests
Price :
US 124.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.125 ug)/test
Species :
Human
Clone :
RPA-T8
Isotype :
IgG1, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.125 ug)/test
Aliases :
BB154331; CD8; CD8 alpha; CD8 alpha chain; CD8 alpha chain precursor; CD8 antigen; CD8 antigen 32 kDa chain; CD8 antigen 37 kDa chain; CD8 antigen alpha polypeptide; CD8 antigen alpha protein; CD8 antigen alpha protein precursor; CD8 antigen alpha-chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, alpha chain; CD8 antigen, alpha polypeptide; CD8 antigen, alpha polypeptide (p32); CD8 antigen, alpha-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8 beta-2; CD8a; CD8A antigen alpha; CD8a molecule; CD8A; T-cell surface glycoprotein; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; Cd8b1; CD8beta; CD8BP; fCD8; LEU2; Leu-2; Leu2 T-lymphocyte antigen; leu-2a; Ly-2; LY3; Ly-3; Ly-35; Ly-B; Ly-C; Lymphocyte antigen 3; Lyt2; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); Lyt3; Lyt-3; MAL; membrane glycoprotein; membrane protein; OKT8 T-cell antigen; OX-8 membrane antigen; p32; P37; RHACD8-4; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T8 T-cell antigen; T-cell antigen Leu2; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3; T-cell surface molecule; T-lymphocyte differentiation antigen T8/Leu-2; type I transmembrane glycoprotein
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA