product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
SOX2 Monoclonal Antibody (Btjce), Alexa Fluor™ 488, eBioscience
catalog :
53-9811-82
quantity :
100 µg
price :
US 435
clonality :
monoclonal
host :
rat
conjugate :
AF488
clone name :
Btjce
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 45
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...
Deng H, Gao Y, Trappetti V, Hertig D, Karatkevich D, Losmanová T, et al. Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. Cell Mol Life Sci. 2022;79:445 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; tbl 1
Chen K, Harris L, Lim J, Harvey T, Piper M, Gronostajski R, et al. Differential neuronal and glial expression of nuclear factor I proteins in the cerebral cortex of adult mice. J Comp Neurol. 2017;525:2465-2483 pubmed publisher
  • immunocytochemistry; mouse; 1:50; loading ...; tbl 2
Li Y, Adomat H, Guns E, Hojabrpour P, Duronio V, Curran T, et al. Identification of a Hematopoietic Cell Dedifferentiation-Inducing Factor. J Cell Physiol. 2016;231:1350-63 pubmed publisher
Wang C, Zhang L, Cao M, Fu Z, Wang H, Zhang S, et al. Thioredoxin facilitates hepatocellular carcinoma stemness and metastasis by increasing BACH1 stability to activate the AKT/mTOR pathway. FASEB J. 2023;37:e22943 pubmed publisher
Bulut M, Vila Cuenca M, de Graaf M, van den Hil F, Mummery C, Orlova V. Three-Dimensional Vessels-on-a-Chip Based on hiPSC-derived Vascular Endothelial and Smooth Muscle Cells. Curr Protoc. 2022;2:e564 pubmed publisher
Frederico B, Martins I, Chapela D, Gasparrini F, Chakravarty P, Ackels T, et al. DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential. Dev Cell. 2022;57:1957-1975.e9 pubmed publisher
Doerfler R, Melamed J, Whitehead K. The Effect of Infant Gastric Digestion on Human Maternal Milk Cells. Mol Nutr Food Res. 2022;66:e2200090 pubmed publisher
Hiramatsu N, Yamamoto N, Kato Y, Nagai N, Isogai S, Imaizumi K. Formation of three-dimensional cell aggregates expressing lens-specific proteins in various cultures of human iris-derived tissue cells and iPS cells. Exp Ther Med. 2022;24:539 pubmed publisher
Hoye M, Calviello L, Poff A, Ejimogu N, Newman C, Montgomery M, et al. Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model. elife. 2022;11: pubmed publisher
B xe9 renger Currias N, Mircea M, Adegeest E, van den Berg P, Feliksik M, Hochane M, et al. A gastruloid model of the interaction between embryonic and extra-embryonic cell types. J Tissue Eng. 2022;13:20417314221103042 pubmed publisher
Belgacemi R, Danopoulos S, Deutsch G, Glass I, Dormoy V, Bellusci S, et al. Hedgehog Signaling Pathway Orchestrates Human Lung Branching Morphogenesis. Int J Mol Sci. 2022;23: pubmed publisher
Choy Buentello D, Koch L, Trujillo de Santiago G, Alvarez M, Broersen K. Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies. PLoS ONE. 2022;17:e0262062 pubmed publisher
Lambert E, Saha O, Soares Landeira B, Melo de Farias A, Hermant X, Carrier A, et al. The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects. Acta Neuropathol Commun. 2022;10:4 pubmed publisher
Valcourt J, Huang R, Kundu S, Venkatasubramanian D, Kingston R, Ramanathan S. Modulating mesendoderm competence during human germ layer differentiation. Cell Rep. 2021;37:109990 pubmed publisher
Mirzaei R, Gordon A, Zemp F, Kumar M, Sarkar S, Luchman H, et al. PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway. Sci Adv. 2021;7:eabh2148 pubmed publisher
Suong D, Imamura K, Inoue I, Kabai R, Sakamoto S, Okumura T, et al. Induction of inverted morphology in brain organoids by vertical-mixing bioreactors. Commun Biol. 2021;4:1213 pubmed publisher
Austin S, Gabarr xf3 Solanas R, Rigo P, Paun O, Harris L, Guillemot F, et al. Wnt/β-catenin signalling is dispensable for adult neural stem cell homeostasis and activation. Development. 2021;148: pubmed publisher
Liu C, Pan Z, Chen Q, Chen Z, Liu W, Wu L, et al. Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer. J Exp Clin Cancer Res. 2021;40:297 pubmed publisher
Morgani S, Hadjantonakis A. Quantitative analysis of signaling responses during mouse primordial germ cell specification. Biol Open. 2021;10: pubmed publisher
Kojic M, Gawda T, Gaik M, Begg A, Salerno Kochan A, Kurniawan N, et al. Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Nat Commun. 2021;12:2678 pubmed publisher
Morgani S, Su J, Nichols J, Massague J, Hadjantonakis A. The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos. elife. 2021;10: pubmed publisher
Dzikowski L, Mirzaei R, Sarkar S, Kumar M, Bose P, Bellail A, et al. Fibrinogen in the glioblastoma microenvironment contributes to the invasiveness of brain tumor-initiating cells. Brain Pathol. 2021;31:e12947 pubmed publisher
Siljee S, Buchanan O, Brasch H, Bockett N, Patel J, Paterson E, et al. Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System. Cells. 2021;10: pubmed publisher
Kinoshita M, Barber M, Mansfield W, Cui Y, Spindlow D, Stirparo G, et al. Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency. Cell Stem Cell. 2021;28:453-471.e8 pubmed publisher
Ahn L, Coatti G, Liu J, Gumus E, Schaffer A, Miranda H. An epilepsy-associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model. J Neurosci Res. 2021;99:110-123 pubmed publisher
Sugiura A, Shimizu T, Kameyama T, Maruo T, Kedashiro S, Miyata M, et al. Identification of Sox2 and NeuN Double-Positive Cells in the Mouse Hypothalamic Arcuate Nucleus and Their Reduction in Number With Aging. Front Aging Neurosci. 2020;12:609911 pubmed publisher
Siljee S, Pilkington T, Brasch H, Bockett N, Patel J, Paterson E, et al. Cancer Stem Cells in Head and Neck Metastatic Malignant Melanoma Express Components of the Renin-Angiotensin System. Life (Basel). 2020;10: pubmed publisher
Ramos Ibeas P, Lamas Toranzo I, Martínez Moro Á, de Frutos C, Quiroga A, Zurita E, et al. Embryonic disc formation following post-hatching bovine embryo development in vitro. Reproduction. 2020;160:579-589 pubmed publisher
Peculis R, Mandrika I, Petrovska R, Dortane R, Megnis K, Nazarovs J, et al. Pituispheres Contain Genetic Variants Characteristic to Pituitary Adenoma Tumor Tissue. Front Endocrinol (Lausanne). 2020;11:313 pubmed publisher
Trus I, Bérubé N, Jiang P, Rak J, Gerdts V, Karniychuk U. Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells. Viruses. 2020;12: pubmed publisher
Hoffman M, Zylla J, Bhattacharya S, Calar K, Hartman T, Bhardwaj R, et al. Analysis of Dual Class I Histone Deacetylase and Lysine Demethylase Inhibitor Domatinostat (4SC-202) on Growth and Cellular and Genomic Landscape of Atypical Teratoid/Rhabdoid. Cancers (Basel). 2020;12: pubmed publisher
Mitchell A, Wanczyk H, JENSEN T, Finck C. Human induced pluripotent stem cells ameliorate hyperoxia-induced lung injury in a mouse model. Am J Transl Res. 2020;12:292-307 pubmed
Oishi S, Zalucki O, Vega M, Harkins D, Harvey T, Kasherman M, et al. Investigating cortical features of Sotos syndrome using mice heterozygous for Nsd1. Genes Brain Behav. 2020;19:e12637 pubmed publisher
Vardhana S, Arnold P, Rosen B, Chen Y, Carey B, Huangfu D, et al. Glutamine independence is a selectable feature of pluripotent stem cells. Nat Metab. 2019;1:676-687 pubmed publisher
Cameron B, Traver G, Roland J, Brockman A, Dean D, Johnson L, et al. Bcl2-Expressing Quiescent Type B Neural Stem Cells in the Ventricular-Subventricular Zone Are Resistant to Concurrent Temozolomide/X-Irradiation. Stem Cells. 2019;37:1629-1639 pubmed publisher
Lee K, Cho H, Rickert R, Li Q, Pulecio J, Leslie C, et al. FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation. Cell Rep. 2019;28:382-393.e7 pubmed publisher
Lazarus K, Hadi F, Zambon E, Bach K, Santolla M, Watson J, et al. BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma. Nat Commun. 2018;9:3327 pubmed publisher
Yang Y, Riccio P, Schotsaert M, Mori M, LU J, Lee D, et al. Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways. Dev Cell. 2018;44:752-761.e4 pubmed publisher
Morgani S, Metzger J, Nichols J, Siggia E, Hadjantonakis A. Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning. elife. 2018;7: pubmed publisher
Harris L, Zalucki O, Oishi S, Burne T, Jhaveri D, Piper M. A morphology independent approach for identifying dividing adult neural stem cells in the mouse hippocampus. Dev Dyn. 2018;247:194-200 pubmed publisher
Bouma M, van Iterson M, Janssen B, Mummery C, Salvatori D, Freund C. Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays. Stem Cell Reports. 2017;8:1340-1353 pubmed publisher
Jang S, Choubey S, Furchtgott L, Zou L, Doyle A, Menon V, et al. Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states. elife. 2017;6: pubmed publisher
Oishi S, Premarathne S, Harvey T, Iyer S, Dixon C, Alexander S, et al. Usp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus. Sci Rep. 2016;6:25783 pubmed publisher
Alexandrova S, Kalkan T, Humphreys P, Riddell A, Scognamiglio R, Trumpp A, et al. Selection and dynamics of embryonic stem cell integration into early mouse embryos. Development. 2016;143:24-34 pubmed publisher
Yamamizu K, Schlessinger D, Ko M. SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1). Development. 2014;141:4254-66 pubmed publisher
product information
Product Type :
Antibody
Product Name :
SOX2 Monoclonal Antibody (Btjce), Alexa Fluor™ 488, eBioscience
Catalog # :
53-9811-82
Quantity :
100 µg
Price :
US 435
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: 0.25 µg/mL, Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent
Species :
Human, Mouse
Clone :
Btjce
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/mL, Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Frozen): Assay-Dependent, Immunohistochemistry (Paraffin): Assay-Dependent
Aliases :
ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MCOPS3 (Microphthalmia Syndromic type 3); RGD1565646; sex determining region Y-box 2; SOX 2; SOX2; Sox-2; soxp; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box 2; SRY-box 2; SOX2; SRY-box containing gene 2; SRY-box transcription factor 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2; wu:fb83g04; wu:fc14d07; ysb; zgc:65860; zgc:77389
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA