Insulin Monoclonal Antibody (ICBTACLS), Alexa Fluor™ 488, eBioscience | Invitrogen 53-9769-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Insulin Monoclonal Antibody (ICBTACLS), Alexa Fluor™ 488, eBioscience

catalog :

53-9769-82

quantity :

100 µg

price :

US 466

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

ICBTACLS

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 3a	Sheng J, Wang L, Tang P, Wang H, Li J, Xu B, et al. Smad3 deficiency promotes beta cell proliferation and function in db/db mice via restoring Pax6 expression. Theranostics. 2021;11:2845-2859 pubmed publisher
immunohistochemistry - paraffin section; human; 1:400; loading ...; fig 1a	Anquetil F, Mondanelli G, Gonzalez N, Rodríguez Calvo T, Zapardiel Gonzalo J, Krogvold L, et al. Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes. Diabetes. 2018;67:1858-1866 pubmed publisher
	Lee D, An T, Kim H, Jung E, Kim G, Oh S, et al. Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice. Diabetologia. 2023;66:931-954 pubmed publisher
	Wu Y, Wong C, Chiles E, Mellinger A, Bae H, Jung S, et al. Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance. Cell Metab. 2022;34:1042-1053.e6 pubmed publisher
	Mukhuty A, Fouzder C, Kundu R. Fetuin-A secretion from β-cells leads to accumulation of macrophages in islets, aggravates inflammation and impairs insulin secretion. J Cell Sci. 2021;134: pubmed publisher
	Wigger L, Barovic M, Brunner A, Marzetta F, Sch xf6 niger E, Mehl F, et al. Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes. Nat Metab. 2021;3:1017-1031 pubmed publisher
	Bao Y, Zhao Z, Gao H. Effect of hTIMP-1 overexpression in human umbilical cord mesenchymal stem cells on the repair of pancreatic islets in type-1 diabetic mice. Cell Biol Int. 2021;45:1038-1049 pubmed publisher
	Rajendran S, Graef M, Chu T, von Herrath M. IL-4R is expressed on alpha and beta cells of human pancreata. Clin Immunol. 2020;214:108394 pubmed publisher
	Abdelrazek H, Kilany O, Muhammad M, Tag H, Abdelazim A. Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats. Oxid Med Cell Longev. 2018;2018:8104165 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Insulin Monoclonal Antibody (ICBTACLS), Alexa Fluor™ 488, eBioscience

Catalog # :

53-9769-82

Quantity :

100 µg

Price :

US 466

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL

Species :

Human, Mouse, Rat

Clone :

ICBTACLS

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL

Aliases :

AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2; Ins-2; Ins2-rs1; InsII; Insulin; insulin 1; insulin 2; Insulin A chain; Insulin B chain; insulin I; insulin II; insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; IRDN; Mody; MODY10; Mody4; preproinsulin; proinsulin

more info or order :

Invitrogen product webpage