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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD284 (TLR4) Monoclonal Antibody (UT41), Alexa Fluor™ 488, eBioscience
catalog :
53-9041-82
quantity :
100 µg
price :
US 377.00
clonality :
monoclonal
host :
mouse
conjugate :
AF488
clone name :
UT41
reactivity :
mouse
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 39
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; loading ...; fig s5a
Millrine D, Tei M, Gemechu Y, Kishimoto T. Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production. Proc Natl Acad Sci U S A. 2016;113:10625-30 pubmed publisher
  • flow cytometry; mouse; fig 5
Yu Y, Cui Y, Zhao Y, Liu S, Song G, Jiao P, et al. The binding capability of plasma phospholipid transfer protein, but not HDL pool size, is critical to repress LPS induced inflammation. Sci Rep. 2016;6:20845 pubmed publisher
Wu Y, Fan X, Yu H, Liu J, Duan Y, Zhang S, et al. Macrophage polarization is involved in liver fibrosis induced by β 1-adrenoceptor autoantibody. Acta Biochim Biophys Sin (Shanghai). 2022;54:1100-1112 pubmed publisher
Xue Q, Liu X, Chen C, Zhang X, Xie P, Liu Y, et al. Erlotinib protests against LPS-induced parthanatos through inhibiting macrophage surface TLR4 expression. Cell Death Discov. 2021;7:181 pubmed publisher
Kitaura A, Nishinaka T, Hamasaki S, Hatipoglu O, Wake H, Nishibori M, et al. Advanced glycation end-products reduce lipopolysaccharide uptake by macrophages. PLoS ONE. 2021;16:e0245957 pubmed publisher
Akhtar M, Mishra M, Yadav V, Yadav M, Gujar R, Lal S, et al. Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells. PLoS Pathog. 2020;16:e1009136 pubmed publisher
Petrovic I, Pejnovic N, Ljujic B, Pavlovic S, Miletic Kovacevic M, Jeftic I, et al. Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice. Front Endocrinol (Lausanne). 2020;11:30 pubmed publisher
Xue J, Yu Y, Zhang X, Zhang C, Zhao Y, Liu B, et al. Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll-Like Receptor 4 to Lipid Rafts. J Am Heart Assoc. 2019;8:e012885 pubmed publisher
Thom S, Bhopale V, Yu K, Yang M. Provocative decompression causes diffuse vascular injury in mice mediated by microparticles containing interleukin-1β. J Appl Physiol (1985). 2018;: pubmed publisher
Thevaranjan N, Puchta A, Schulz C, Naidoo A, Szamosi J, Verschoor C, et al. Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host Microbe. 2017;21:455-466.e4 pubmed publisher
Li Z, Scott M, Fan E, Li Y, Liu J, Xiao G, et al. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ. 2016;23:1428-47 pubmed publisher
Ninkovic J, Jana N, Anand V, Vidhu A, Dutta R, Raini D, et al. Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis. Sci Rep. 2016;6:21094 pubmed publisher
Dutta R, Roy S. Chronic morphine and HIV-1 Tat promote differential central nervous system trafficking of CD3+ and Ly6C+ immune cells in a murine Streptococcus pneumoniae infection model. J Neuroinflammation. 2015;12:120 pubmed publisher
Xue J, Habtezion A. Carbon monoxide-based therapy ameliorates acute pancreatitis via TLR4 inhibition. J Clin Invest. 2014;124:437-47 pubmed publisher
Li X, Wang J, Wang W, Liu C, Sun S, Gu J, et al. Immunomodulatory activity of a novel, synthetic beta-glucan (?-glu6) in murine macrophages and human peripheral blood mononuclear cells. PLoS ONE. 2013;8:e80399 pubmed publisher
Thirunavukkarasu S, de Silva K, Whittington R, Plain K. In vivo and in vitro expression pattern of Toll-like receptors in Mycobacterium avium subspecies paratuberculosis infection. Vet Immunol Immunopathol. 2013;156:20-31 pubmed publisher
Liu C, Zhang C, Mitchel R, Cui J, Lin J, Yang Y, et al. A critical role of toll-like receptor 4 (TLR4) and its' in vivo ligands in basal radio-resistance. Cell Death Dis. 2013;4:e649 pubmed publisher
Casella C, Mitchell T. Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A. PLoS ONE. 2013;8:e62622 pubmed publisher
Liu B, Fu Y, Feng S, Zhang X, Liu Z, Cao Y, et al. Involvement of RP105 and toll-like receptors in the activation of mouse peritoneal macrophages by Staphylococcus aureus. Scand J Immunol. 2013;78:8-16 pubmed publisher
Roberts B, Dragon J, Moussawi M, Huber S. Sex-specific signaling through Toll-Like Receptors 2 and 4 contributes to survival outcome of Coxsackievirus B3 infection in C57Bl/6 mice. Biol Sex Differ. 2012;3:25 pubmed publisher
Aaron J, Carson B, Timlin J. Characterization of differential Toll-like receptor responses below the optical diffraction limit. Small. 2012;8:3041-9 pubmed publisher
Lee H, Hattori T, Park E, Stevenson W, Chauhan S, Dana R. Expression of toll-like receptor 4 contributes to corneal inflammation in experimental dry eye disease. Invest Ophthalmol Vis Sci. 2012;53:5632-40 pubmed publisher
Yang D, Liu Y, Chen Y, Jiao D, Hou X, Wang L, et al. Pretreatment with Mycobacterium avium-derived lipids attenuates the response of murine macrophages to components of Mycobacterium tuberculosis. Int J Mol Med. 2012;29:1072-82 pubmed publisher
Traves P, López Fontal R, Luque A, Hortelano S. The tumor suppressor ARF regulates innate immune responses in mice. J Immunol. 2011;187:6527-38 pubmed publisher
Yang H, Wang J, Mi S, Liu H, Cui B, Yan H, et al. TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol. 2012;180:275-92 pubmed publisher
Levin M, Jirholt P, Wramstedt A, Johansson M, Lundberg A, Trajkovska M, et al. Rip2 deficiency leads to increased atherosclerosis despite decreased inflammation. Circ Res. 2011;109:1210-8 pubmed publisher
Scotland R, Stables M, Madalli S, Watson P, Gilroy D. Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice. Blood. 2011;118:5918-27 pubmed publisher
Miranda Hernandez S, Gerlach N, Fletcher J, Biros E, Mack M, Korner H, et al. Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in experimental autoimmune encephalomyelitis. J Immunol. 2011;187:791-804 pubmed publisher
Li Z, Potts E, Piantadosi C, Foster W, Hollingsworth J. Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide. J Immunol. 2010;185:6891-8 pubmed publisher
Niess J, Adler G. Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. J Immunol. 2010;184:2026-37 pubmed publisher
Oliveira C, Carvalho W, Garcia G, Gutierrez F, De Miranda Santos I, Silva J, et al. Tick saliva induces regulatory dendritic cells: MAP-kinases and Toll-like receptor-2 expression as potential targets. Vet Parasitol. 2010;167:288-97 pubmed publisher
Wang L, Harrington L, Trebicka E, Shi H, Kagan J, Hong C, et al. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest. 2009;119:3322-8 pubmed publisher
Segura E, Wong J, Villadangos J. Cutting edge: B220+CCR9- dendritic cells are not plasmacytoid dendritic cells but are precursors of conventional dendritic cells. J Immunol. 2009;183:1514-7 pubmed publisher
Dasu M, Park S, Devaraj S, Jialal I. Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice. Endocrinology. 2009;150:3457-64 pubmed publisher
Meyer M, Huaux F, Gavilanes X, van den Brule S, Lebecque P, Lo Re S, et al. Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis. Am J Respir Cell Mol Biol. 2009;41:590-602 pubmed publisher
Bi Y, Du Z, Han Y, Guo Z, Tan Y, Zhu Z, et al. Yersinia pestis and host macrophages: immunodeficiency of mouse macrophages induced by YscW. Immunology. 2009;128:e406-17 pubmed publisher
Tokita D, Sumpter T, Raimondi G, Zahorchak A, Wang Z, Nakao A, et al. Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells. J Hepatol. 2008;49:1008-18 pubmed publisher
Dasu M, Riosvelasco A, Jialal I. Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo. Atherosclerosis. 2009;202:76-83 pubmed publisher
Hollingsworth J, Maruoka S, Li Z, Potts E, Brass D, Garantziotis S, et al. Ambient ozone primes pulmonary innate immunity in mice. J Immunol. 2007;179:4367-75 pubmed
product information
Product Type :
Antibody
Product Name :
CD284 (TLR4) Monoclonal Antibody (UT41), Alexa Fluor™ 488, eBioscience
Catalog # :
53-9041-82
Quantity :
100 µg
Price :
US 377.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 µg/test
Species :
Mouse
Clone :
UT41
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test
Aliases :
ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA