CD326 (EpCAM) Monoclonal Antibody (MH99), Alexa Fluor™ 488, eBioscience | Invitrogen 53-8326-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD326 (EpCAM) Monoclonal Antibody (MH99), Alexa Fluor™ 488, eBioscience

catalog :

53-8326-42

quantity :

100 Tests

price :

US 358.00

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

MH99

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig s2a	Sinkala E, Sollier Christen E, Renier C, Rosàs Canyelles E, Che J, Heirich K, et al. Profiling protein expression in circulating tumour cells using microfluidic western blotting. Nat Commun. 2017;8:14622 pubmed publisher
	Verbruggen S, Thompson C, Duffy M, Lunetto S, Nolan J, Pearce O, et al. Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype. Cancers (Basel). 2021;13: pubmed publisher
	Malacrida B, Nichols S, Maniati E, Jones R, Delanie Smith R, Roozitalab R, et al. A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion. iScience. 2021;24:102676 pubmed publisher
	Delaine Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, et al. Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer. iScience. 2021;24:102674 pubmed publisher
	Rao C, Chianese D, Doyle G, Miller M, Russell T, Sanders R, et al. Expression of epithelial cell adhesion molecule in carcinoma cells present in blood and primary and metastatic tumors. Int J Oncol. 2005;27:49-57 pubmed
	Federici M, Kudryashov V, Saigo P, Finstad C, Lloyd K. Selection of carbohydrate antigens in human epithelial ovarian cancers as targets for immunotherapy: serous and mucinous tumors exhibit distinctive patterns of expression. Int J Cancer. 1999;81:193-8 pubmed
	Litvinov S, Velders M, Bakker H, Fleuren G, Warnaar S. Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol. 1994;125:437-46 pubmed
	Litvinov S, Bakker H, Gourevitch M, Velders M, Warnaar S. Evidence for a role of the epithelial glycoprotein 40 (Ep-CAM) in epithelial cell-cell adhesion. Cell Adhes Commun. 1994;2:417-28 pubmed
	Mattes M, Cairncross J, Old L, Lloyd K. Monoclonal antibodies to three widely distributed human cell surface antigens. Hybridoma. 1983;2:253-64 pubmed

product information

Product Type :

Antibody

Product Name :

CD326 (EpCAM) Monoclonal Antibody (MH99), Alexa Fluor™ 488, eBioscience

Catalog # :

53-8326-42

Quantity :

100 Tests

Price :

US 358.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.5 µg)/test

Species :

Human

Clone :

MH99

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types. Also, Ep-CAM reportedly distinguishes adenocarcinomas from pleural mesotheliomas.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.5 µg)/test

Aliases :

adenocarcinoma-associated antigen; CD326; cell surface glycoprotein Trop-1; DIAR5; EGP; EGP-2; EGP314; EGP40; EPCAM; Ep-CAM; EpCAM1; epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; ESA; GA733-2; gp40; hEGP314; HNPCC8; human epithelial glycoprotein-2; KS 1/4 antigen; KS1/4; KSA; Ly74; lymphocyte antigen 74; M1S2; M4S1; major gastrointestinal tumor-associated protein GA733-2; mEGP314; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; panepithelial glycoprotein 314; protein 289A; Protein D5.7A; Tacsd1; Tacstd1; TROP1; Trop-1 protein; Tumor-associated calcium signal transducer 1

more info or order :

Invitrogen product webpage