IL-12/IL-23 p40 Monoclonal Antibody (C17.8), Alexa Fluor 488, eBioscience™ | Invitrogen 53-7123-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-12/IL-23 p40 Monoclonal Antibody (C17.8), Alexa Fluor 488, eBioscience™

catalog :

53-7123-80

quantity :

25µg

price :

US 139

clonality :

monoclonal

host :

rat

conjugate :

AF488

clone name :

C17.8

reactivity :

mouse

application :

flow cytometry

citations: 6

Reference
Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, et al. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Nat Commun. 2018;9:873 pubmed publisher
Bagchi S, Li S, Wang C. CD1b-autoreactive T cells recognize phospholipid antigens and contribute to antitumor immunity against a CD1b+ T cell lymphoma. Oncoimmunology. 2016;5:e1213932 pubmed
Cicchelero L, Denies S, Devriendt B, de Rooster H, Sanders N. Can dendritic cells improve whole cancer cell vaccines based on immunogenically killed cancer cells?. Oncoimmunology. 2015;4:e1048413 pubmed
Manta C, Heupel E, Radulovic K, Rossini V, Garbi N, Riedel C, et al. CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium. Mucosal Immunol. 2013;6:177-88 pubmed publisher
Cho D, Lee W, Halloran P, Trinchieri G, Kim Y. Enhancement of porcine natural killer cell activity by recombinant human and murine IL-12. Cell Immunol. 1996;172:29-34 pubmed
Aragane Y, Riemann H, Bhardwaj R, Schwarz A, Sawada Y, Yamada H, et al. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 1994;153:5366-72 pubmed

product information

Product Type :

Antibody

Product Name :

IL-12/IL-23 p40 Monoclonal Antibody (C17.8), Alexa Fluor 488, eBioscience™

Catalog # :

53-7123-80

Quantity :

25µg

Price :

US 139

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse

Clone :

C17.8

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

IL12B; Il12p40; interleukin 12B; RP23-388G23.1; Il-12b; Il-12p40; p40; IL-12 p40; IL-23 subunit p40; IL12P40