PARP1 (cleaved Asp214) Monoclonal Antibody (HLNC4), Alexa Fluor 488, eBioscience | Invitrogen 53-6668-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PARP1 (cleaved Asp214) Monoclonal Antibody (HLNC4), Alexa Fluor 488, eBioscience

catalog :

53-6668-42

quantity :

100 Tests

price :

US 368.00

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

HLNC4

reactivity :

human

application :

flow cytometry

citations: 5

Reference
Patel T, Gores G, Kaufmann S. The role of proteases during apoptosis. FASEB J. 1996;10:587-97 pubmed
Tewari M, Quan L, O Rourke K, Desnoyers S, Zeng Z, Beidler D, et al. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 1995;81:801-9 pubmed
Zahradka P, Ebisuzaki K. Poly(ADP-ribose) polymerase is a zinc metalloenzyme. Eur J Biochem. 1984;142:503-9 pubmed
Lamarre D, Talbot B, de Murcia G, Laplante C, Leduc Y, Mazen A, et al. Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study. Biochim Biophys Acta. 1988;950:147-60 pubmed
Lamarre D, Talbot B, Leduc Y, Muller S, Poirier G. Production and characterization of monoclonal antibodies specific for the functional domains of poly(ADP-ribose) polymerase. Biochem Cell Biol. 1986;64:368-76 pubmed

product information

Product Type :

Antibody

Product Name :

PARP1 (cleaved Asp214) Monoclonal Antibody (HLNC4), Alexa Fluor 488, eBioscience

Catalog # :

53-6668-42

Quantity :

100 Tests

Price :

US 368.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.015 ug)/test

Species :

Human

Clone :

HLNC4

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Poly ADP-Ribose Polymerase (PARP) uses nicotinamide adenine dinucleotide (oxidized form) NAD as a substrate to catalyse the transfer of ADP-ribose to a variety of nuclear protein acceptors. Proteolysis of PARP to its stable 85kDa fragment is an early marker of programmed cell death (apoptosis) and is mediated by the caspase CPP32 protein. Cleavage occurs between Adp216 and Gly217, a site in PARP conserved across species.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.015 ug)/test

Aliases :

5830444G22Rik; ADP-ribosyltransferase (NAD+; ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase); ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1; ADP-ribosyltransferase 1; ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); Adprp; Adprt; ADPRT 1; ADPRT1; AI893648; ARTD1; C80510; DNA ADP-ribosyltransferase PARP1; msPARP; NAD(+) ADP-ribosyltransferase 1; pADPRT-1; PARP; Parp1; PARP-1; poly (ADP-ribose) polymerase 1; poly (ADP-ribose) polymerase family, member 1; poly (ADP-ribose) polymerase); poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) polymerase 1; poly(ADP-ribose) polymerase PARP-1; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; poly[ADP-ribose] synthase 1; poly[ADP-ribose] synthetase 1; PPOL; Protein poly-ADP-ribosyltransferase PARP1; sPARP-1; synthetase fragment (AA 67); Unknown (protein for IMAGE:8023736); unnamed protein product