High Endothelial Venule Marker Monoclonal Antibody (MECA-79), Alexa Fluor 488, eBioscience | Invitrogen 53-6036-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

High Endothelial Venule Marker Monoclonal Antibody (MECA-79), Alexa Fluor 488, eBioscience

catalog :

53-6036-80

quantity :

25 ug

price :

US 177.00

clonality :

monoclonal

host :

rat

conjugate :

AF488

clone name :

MECA-79

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 20

Reference
Wang C, Cui A, Bukenya M, Aung A, Pradhan D, Whittaker C, et al. Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade. Cell Rep. 2021;37:110021 pubmed publisher
Fu Y, Wang Z, Yu B, Lin Y, Huang E, Liu R, et al. Intestinal CD11b+ B Cells Ameliorate Colitis by Secreting Immunoglobulin A. Front Immunol. 2021;12:697725 pubmed publisher
Sun Y, Chen W, Torphy R, Yao S, Zhu G, Lin R, et al. Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Sci Transl Med. 2021;13: pubmed publisher
Choe K, Moon J, Lee S, Song E, Back J, Song J, et al. Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venules. Life Sci Alliance. 2021;4: pubmed publisher
Huang S, Ziegler C, Austin J, Mannoun N, Vukovic M, Ordovas Montanes J, et al. Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential. Cell. 2021;184:441-459.e25 pubmed publisher
Lee G, Jun Y, Yoo H, Jeon Y, Lee D, Lee S, et al. Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation. Oncoimmunology. 2020;9:1746553 pubmed publisher
Maarouf O, Uehara M, Kasinath V, Solhjou Z, Banouni N, Bahmani B, et al. Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing. JCI Insight. 2018;3: pubmed publisher
Yoshizawa A, Bi K, Keskin D, Zhang G, Reinhold B, Reinherz E. TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells. Eur J Immunol. 2018;48:128-150 pubmed publisher
Thiriot A, Perdomo C, Cheng G, Novitzky Basso I, McArdle S, Kishimoto J, et al. Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues. BMC Biol. 2017;15:45 pubmed publisher
Arokiasamy S, Zakian C, Dilliway J, Wang W, Nourshargh S, Voisin M. Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation. Sci Rep. 2017;7:44189 pubmed publisher
Dang A, Tesfagiorgis Y, Jain R, Craig H, Kerfoot S. Meningeal Infiltration of the Spinal Cord by Non-Classically Activated B Cells is Associated with Chronic Disease Course in a Spontaneous B Cell-Dependent Model of CNS Autoimmune Disease. Front Immunol. 2015;6:470 pubmed publisher
Khmaladze I, Kelkka T, Guérard S, Wing K, Pizzolla A, Saxena A, et al. Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice. Proc Natl Acad Sci U S A. 2014;111:E3669-78 pubmed publisher
Onder L, Danuser R, Scandella E, Firner S, Chai Q, Hehlgans T, et al. Endothelial cell-specific lymphotoxin-? receptor signaling is critical for lymph node and high endothelial venule formation. J Exp Med. 2013;210:465-73 pubmed publisher
Hindley J, Jones E, Smart K, Bridgeman H, Lauder S, Ondondo B, et al. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion. Cancer Res. 2012;72:5473-82 pubmed publisher
Brown K, Sacks S, Wong W. Tertiary lymphoid organs in renal allografts can be associated with donor-specific tolerance rather than rejection. Eur J Immunol. 2011;41:89-96 pubmed publisher
Nagaoka K, Takahara K, Minamino K, Takeda T, Yoshida Y, Inaba K. Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages, and monocytes. J Leukoc Biol. 2010;88:913-24 pubmed publisher
Sinha R, Yang G, Alexander C, Mage R. De novo expression of MECA-79 glycoprotein-determinant on developing B lymphocytes in gut-associated lymphoid tissues. Immunology. 2006;119:461-9 pubmed
Girard J, Springer T. High endothelial venules (HEVs): specialized endothelium for lymphocyte migration. Immunol Today. 1995;16:449-57 pubmed
Hemmerich S, Butcher E, Rosen S. Sulfation-dependent recognition of high endothelial venules (HEV)-ligands by L-selectin and MECA 79, and adhesion-blocking monoclonal antibody. J Exp Med. 1994;180:2219-26 pubmed
Streeter P, Rouse B, Butcher E. Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes. J Cell Biol. 1988;107:1853-62 pubmed

product information

Product Type :

Antibody

Product Name :

High Endothelial Venule Marker Monoclonal Antibody (MECA-79), Alexa Fluor 488, eBioscience

Catalog # :

53-6036-80

Quantity :

25 ug

Price :

US 177.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: Assay-Dependent, Immunocytochemistry: 20 ug/mL, Immunohistochemistry (Paraffin): 20 ug/mL

Species :

Human, Mouse

Clone :

MECA-79

Isotype :

IgM

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

HEV peripheral lymph node addressin (PNAd) is a glycoprotein is expressed on the luminal surface and in the cytoplasm of HEVs in lymphoid tissues, including peripheral and mesenteric lymph nodes and, to a lesser extent, Peyer's patches. The MECA-79 antigen has also been detected on follicular B cells in the spleen and appendix in humans, as well as at sites of chronic inflammation. Post-capillary venules or large vessels in the spleen, thymus, or non-lymphoid tissues do not express the MECA-79 antigen and thus cannot be detected with this antibody. This addressin is involved in lymphocyte infiltration and adhesion into secondary lymphoid tissues.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent, Immunocytochemistry: 20 ug/mL, Immunohistochemistry (Paraffin): 20 ug/mL

Aliases :

HEV; MECA-79; PNAd