FOXP3 Monoclonal Antibody (150D/E4), Alexa Fluor™ 488, eBioscience | Invitrogen 53-4774-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FOXP3 Monoclonal Antibody (150D/E4), Alexa Fluor™ 488, eBioscience

catalog :

53-4774-42

quantity :

100 Tests

price :

US 394

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

150D/E4

reactivity :

human, mouse, rat

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 3	Kim Y, Lim H, Jung H, Wetsel R, Chung Y. Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. PLoS ONE. 2015;10:e0120294 pubmed publisher
	Glaubitz J, Wilden A, Golchert J, Homuth G, V xf6 lker U, Br xf6 ker B, et al. In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response. Nat Commun. 2022;13:4502 pubmed publisher
	Lebel M, Coutelier M, Galipeau M, Kleinman C, Moon J, Melichar H. Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates. Nat Commun. 2020;11:3734 pubmed publisher
	Court A, Le Gatt A, Luz Crawford P, Parra E, Aliaga Tobar V, Batiz L, et al. Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response. EMBO Rep. 2020;21:e48052 pubmed publisher
	Huang J, Wang L, Dahiya S, Beier U, Han R, Samanta A, et al. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep. 2017;7:8626 pubmed publisher
	Jacobs J, Lin L, Goudarzi M, Ruegger P, McGovern D, Fornace A, et al. Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency. Gut Microbes. 2017;8:1-16 pubmed publisher
	Zang X, Jiang Y, Li X, Du Y, Niu J. Characteristics of CD4+CD25+Foxp3+ regulatory T cells in patients with multiple organ dysfunction syndrome. Exp Ther Med. 2016;11:1908-1912 pubmed
	De Rosa V, Galgani M, Porcellini A, Colamatteo A, Santopaolo M, Zuchegna C, et al. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants. Nat Immunol. 2015;16:1174-84 pubmed publisher
	Rodrigues DÃez R, Rayego Mateos S, Orejudo M, Aroeira L, Selgas R, Ortiz A, et al. TGF-Beta Blockade Increases Renal Inflammation Caused by the C-Terminal Module of the CCN2. Mediators Inflamm. 2015;2015:506041 pubmed publisher
	Guo C, Kogan S, Amano S, Wang M, Dagdeviren S, Friedline R, et al. CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance. Am J Physiol Endocrinol Metab. 2013;304:E951-63 pubmed publisher
	Fontenot J, Rasmussen J, Williams L, Dooley J, Farr A, Rudensky A. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 2005;22:329-41 pubmed
	Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057-61 pubmed

product information

Product Type :

Antibody

Product Name :

FOXP3 Monoclonal Antibody (150D/E4), Alexa Fluor™ 488, eBioscience

Catalog # :

53-4774-42

Quantity :

100 Tests

Price :

US 394

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 5 µL (0.5 µg)/test

Species :

Human, Mouse, Rat

Clone :

150D/E4

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.5 µg)/test

Aliases :

AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID

more info or order :

Invitrogen product webpage