Arginase 1 Monoclonal Antibody (A1exF5), Alexa Fluor 488, eBioscience | Invitrogen 53-3697-80 product information

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product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Arginase 1 Monoclonal Antibody (A1exF5), Alexa Fluor 488, eBioscience

catalog :

53-3697-80

quantity :

25 ug

price :

US 155.00

clonality :

monoclonal

host :

rat

conjugate :

AF488

clone name :

A1exF5

reactivity :

human, mouse

application :

flow cytometry

citations: 28

Reference
Yang J, Xie Y, Xia Z, Ji S, Yang X, Yue D, et al. HucMSC-Exo Induced N2 Polarization of Neutrophils: Implications for Angiogenesis and Tissue Restoration in Wound Healing. Int J Nanomedicine. 2024;19:3555-3575 pubmed publisher
Griffin K, Mizenko R, Arun V, Carney R, Leach J. Extracellular Vesicles from Highly Metastatic Osteosarcoma Cells Induce Pro-Tumorigenic Macrophage Phenotypes. Adv Biol (Weinh). 2024;8:e2300577 pubmed publisher
Zimarino C, MOODY W, Davidson S, Munir H, Shields J. Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells. iScience. 2024;27:109546 pubmed publisher
Yang F, Akhtar M, Zhang D, El Mayta R, Shin J, Dorsey J, et al. An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Sci Adv. 2024;10:eadj4678 pubmed publisher
Yang J, Shuai J, Siow L, Lu J, Sun M, An W, et al. MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment. Bone Res. 2024;12:2 pubmed publisher
Liu Y, Zhan Z, Kang Z, Li M, Lv Y, Li S, et al. Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma. Acta Pharm Sin B. 2023;13:4748-4764 pubmed publisher
Bokil A, Le Boulvais B xf8 rkja M, Wolowczyk C, Lamsal A, Prestvik W, Nonstad U, et al. Discovery of a new marker to identify myeloid cells associated with metastatic breast tumours. Cancer Cell Int. 2023;23:279 pubmed publisher
Sheng W, Qin H, Wang T, Zhao J, Fang C, Zhang P, et al. Advanced phosphocreatine-grafted chitosan hydrogel promote wound healing by macrophage modulation. Front Bioeng Biotechnol. 2023;11:1199939 pubmed publisher
Brigo N, Neumaier E, Pfeifhofer Obermair C, Grubwieser P, Engl S, Berger S, et al. Timing of Interleukin-4 Stimulation of Macrophages Determines Their Anti-Microbial Activity during Infection with Salmonella enterica Serovar Typhimurium. Cells. 2023;12: pubmed publisher
Martins Nascentes Melo L, Herrera Rios D, Hinze D, L xf6 ffek S, Oezel I, Turiello R, et al. Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma. J Immunother Cancer. 2023;11: pubmed publisher
Feng L, Luo G, Li Y, Zhang C, Liu Y, Liu Y, et al. Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis. Vet Res. 2023;54:25 pubmed publisher
Li C, Anuraga G, Chang C, Weng T, Hsu H, Ta H, et al. Repurposing nitric oxide donating drugs in cancer therapy through immune modulation. J Exp Clin Cancer Res. 2023;42:22 pubmed publisher
Liao W, Foo H, Tran T, Chai C, Wong W. Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function. Br J Pharmacol. 2023;180:1056-1071 pubmed publisher
Dumigan A, Cappa O, Morris B, S xe1 Pessoa J, Calderón Gonzalez R, Mills G, et al. In vivo single-cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection. EMBO Mol Med. 2022;14:e16888 pubmed publisher
Wu H, Liu K, Zhang J. LINC00240/miR-155 axis regulates function of trophoblasts and M2 macrophage polarization via modulating oxidative stress-induced pyroptosis in preeclampsia. Mol Med. 2022;28:119 pubmed publisher
Chryplewicz A, Scotton J, Tichet M, Zomer A, Shchors K, Joyce J, et al. Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity. Cancer Cell. 2022;40:1111-1127.e9 pubmed publisher
Liu Y, Zhai R, Tong J, Yu Y, Yang L, Gu Y, et al. Angiotensin 1-7 and its analogue decrease blood pressure but aggravate renal damage in preeclamptic mice. Exp Anim. 2022;71:519-528 pubmed publisher
Gao T, Huang F, Wang W, Xie Y, Wang B. Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages. Cell Mol Biol Lett. 2022;27:27 pubmed publisher
Dichtl S, Sanin D, Koss C, Willenborg S, Petzold A, Tanzer M, et al. Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF. Life Sci Alliance. 2022;5: pubmed publisher
Trofimova O, Korotkaja K, Skrastina D, Jansons J, Spunde K, Isaguliants M, et al. Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model. Vaccines (Basel). 2021;9: pubmed publisher
Dichtl S, Lindenthal L, Zeitler L, Behnke K, Schlösser D, Strobl B, et al. Lactate and IL6 define separable paths of inflammatory metabolic adaptation. Sci Adv. 2021;7: pubmed publisher
Deng J, Tan S, Liu R, Yu W, Chen H, Tang N, et al. Chinese Medicine Formula PSORI-CM02 Alleviates Psoriatic Dermatitis via M-MDSCs and Th17 Crosstalk. Front Pharmacol. 2020;11:563433 pubmed publisher
Josefs T, Basu D, Vaisar T, Arets B, Kanter J, Huggins L, et al. Atherosclerosis Regression and Cholesterol Efflux in Hypertriglyceridemic Mice. Circ Res. 2021;128:690-705 pubmed publisher
Hu Q, Peng J, Jiang L, Li W, Su Q, Zhang J, et al. Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma. Cell Death Dis. 2020;11:925 pubmed publisher
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Yurdagul A, Subramanian M, Wang X, Crown S, Ilkayeva O, Darville L, et al. Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. Cell Metab. 2020;31:518-533.e10 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Arginase 1 Monoclonal Antibody (A1exF5), Alexa Fluor 488, eBioscience

Catalog # :

53-3697-80

Quantity :

25 ug

Price :

US 155.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 1.0 ug/test

Species :

Human, Mouse

Clone :

A1exF5

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.

Immunogen :

E.coli-derived recombinant mouse Arginase 1

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1.0 ug/test

Aliases :

AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase