CD107b (LAMP-2) Monoclonal Antibody (eBioABL-93 (ABL-93)), Alexa Fluor 488, eBioscience | Invitrogen 53-1072-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD107b (LAMP-2) Monoclonal Antibody (eBioABL-93 (ABL-93)), Alexa Fluor 488, eBioscience

catalog :

53-1072-82

quantity :

100 ug

price :

US 300.00

clonality :

monoclonal

host :

rat

conjugate :

AF488

clone name :

eBioABL-93 (ABL-93)

reactivity :

mouse

application :

flow cytometry

citations: 12

Reference
Matsumoto A, Takahashi Y, Chang H, Wu Y, Yamamoto A, Ishihama Y, et al. Blood concentrations of small extracellular vesicles are determined by a balance between abundant secretion and rapid clearance. J Extracell Vesicles. 2020;9:1696517 pubmed publisher
Pelgrim C, Franx B, Snabel J, Kleemann R, Arnoldussen I, Kiliaan A. Butyrate Reduces HFD-Induced Adipocyte Hypertrophy and Metabolic Risk Factors in Obese LDLr-/-.Leiden Mice. Nutrients. 2017;9: pubmed publisher
Ahlqvist K, Leoncini S, Pecorelli A, Wortmann S, Ahola S, ForsstrÃ¶m S, et al. MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction. Nat Commun. 2015;6:6494 pubmed publisher
Jie Z, Liang Y, Hou L, Dong C, Iwakura Y, Soong L, et al. Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection. J Immunol. 2014;192:3289-300 pubmed publisher
Sepulveda F, Debeurme F, Menasche G, Kurowska M, Côte M, Pachlopnik Schmid J, et al. Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. Blood. 2013;121:595-603 pubmed publisher
Osterbur J, Sprague L, Muccioli M, Pate M, Mansfield K, McGinty J, et al. Adhesion to substrates induces dendritic cell endothelization and decreases immunological response. Immunobiology. 2013;218:64-75 pubmed publisher
Fowler C, Pao L, Blattman J, Greenberg P. SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells. J Immunol. 2010;185:3256-67 pubmed publisher
Hovav A, Panas M, Rahman S, Sircar P, Gillard G, Cayabyab M, et al. Duration of antigen expression in vivo following DNA immunization modifies the magnitude, contraction, and secondary responses of CD8+ T lymphocytes. J Immunol. 2007;179:6725-33 pubmed
Hovav A, Cayabyab M, Panas M, Santra S, Greenland J, Geiben R, et al. Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis. J Virol. 2007;81:74-83 pubmed
Tritel M, Stoddard A, Flynn B, Darrah P, Wu C, Wille U, et al. Prime-boost vaccination with HIV-1 Gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and cellular immune responses. J Immunol. 2003;171:2538-47 pubmed
Chen J, Murphy T, Willingham M, Pastan I, August J. Identification of two lysosomal membrane glycoproteins. J Cell Biol. 1985;101:85-95 pubmed
Cha Y, Holland S, August J. The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. J Biol Chem. 1990;265:5008-13 pubmed

product information

Product Type :

Antibody

Product Name :

CD107b (LAMP-2) Monoclonal Antibody (eBioABL-93 (ABL-93)), Alexa Fluor 488, eBioscience

Catalog # :

53-1072-82

Quantity :

100 ug

Price :

US 300.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 ug/test

Species :

Mouse

Clone :

eBioABL-93 (ABL-93)

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide. Mature, functional LAMP2 is extensively glycosylated with a variety of different N-linked and O-linked oligosaccharides with a total molecular weight of about 100-130 kDa. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. LAMP2 is used to monitor a very selective form of autophagy called chaperone-mediated autophagy. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. The LAMP protein has 3 variant forms: LAMP-2A, -2B, and 2C. LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, and LAMP2 is an important regulator in successful phagosomal maturation. LAMP2 deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danon’s disease).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/test

Aliases :

CD107 antigen-like family member B; CD107b; EGK_20887; Igp96; Lamp II; LAMP2; LAMP-2; LAMP-2 Isoform 2A; LAMP-2 Variant A; Lamp-2a; Lamp-2b; Lamp-2c; LAMPB; LGP110; LGP-110; LGP-96; LGP-B; lysosomal associated membrane protein 2; lysosomal membrane glycoprotein 2; lysosomal membrane glycoprotein type B; lysosomal-associated membrane protein 2; lysosome-associated membrane glycoprotein 2; lysosome-associated membrane protein 2; Mac3; RP23-193O17.2