This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD34 Monoclonal Antibody (RAM34), Alexa Fluor 488, eBioscience
catalog :
53-0341-82
quantity :
100 ug
price :
US 277.00
clonality :
monoclonal
host :
rat
conjugate :
AF488
clone name :
RAM34

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 76
Reference
Griffin K, Thorpe S, Sebastian A, Hum N, Coonan T, Sagheb I, et al. Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening. Proc Natl Acad Sci U S A. 2023;120:e2302101120 pubmed publisher
Lee P, Tsai B, Sitorus M, Lin P, Lin S, Shih C, et al. Ohwia caudata aqueous extract attenuates doxorubicin-induced mitochondrial dysfunction in Wharton's jelly-derived mesenchymal stem cells. Environ Toxicol. 2023;38:2450-2461 pubmed publisher
Li N, Wang Y, Wang A, Zhang J, Jia C, Yu C, et al. STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression. Int J Mol Sci. 2023;24: pubmed publisher
Wang G, Zhang Z, Zhong K, Wang Z, Yang N, Tang X, et al. CXCL11-armed oncolytic adenoviruses enhance CAR-T cell therapeutic efficacy and reprogram tumor microenvironment in glioblastoma. Mol Ther. 2023;31:134-153 pubmed publisher
Tarazi S, Aguilera Castrejon A, Joubran C, Ghanem N, Ashouokhi S, Roncato F, et al. Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell. 2022;185:3290-3306.e25 pubmed publisher
Wang Y, Huang Y, Cai W, Tao Q. Multiple benign fibrous histiocytomas of the mandible: A case report and review of the literature. Exp Ther Med. 2022;24:593 pubmed publisher
Lorenzo Mart xed n L, Menacho M xe1 rquez M, Fern xe1 ndez Parejo N, Rodr xed guez Fdez S, Pascual G, Abad A, et al. The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function. Oncogene. 2022;41:3341-3354 pubmed publisher
Prior R, Verschoren S, Vints K, Jaspers T, Rossaert E, Klingl Y, et al. HDAC3 Inhibition Stimulates Myelination in a CMT1A Mouse Model. Mol Neurobiol. 2022;59:3414-3430 pubmed publisher
Flora P, Li M, Galbo P, Astorkia M, Zheng D, Ezhkova E. Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration. PLoS Genet. 2021;17:e1009948 pubmed publisher
Cohen C, Le Goff O, Soysouvanh F, Vasseur F, Tanou M, Nguyen C, et al. Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1. EMBO Mol Med. 2021;13:e14146 pubmed publisher
Tang H, Zhang P, Zeng L, Zhao Y, Xie L, Chen B. Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat. Stem Cell Res Ther. 2021;12:409 pubmed publisher
Yamada S, Yassin M, Schwarz T, Hansmann J, Mustafa K. Induction of osteogenic differentiation of bone marrow stromal cells on 3D polyester-based scaffolds solely by subphysiological fluidic stimulation in a laminar flow bioreactor. J Tissue Eng. 2021;12:20417314211019375 pubmed publisher
Baltanás F, Mucientes Valdivieso C, Lorenzo Martín L, Fernández Parejo N, García Navas R, Segrelles C, et al. Functional Specificity of the Members of the Sos Family of Ras-GEF Activators: Novel Role of Sos2 in Control of Epidermal Stem Cell Homeostasis. Cancers (Basel). 2021;13: pubmed publisher
Sávio Silva C, Soinski Sousa P, Simplício Filho A, Bastos R, Beyerstedt S, Rangel E. Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity. Int J Mol Sci. 2021;22: pubmed publisher
Li Y, Sun X, Zhang X, Zhou H, Wang D, Xia Y, et al. Functional damage of endothelial progenitor cells is attenuated by 14-3-3-n through inhibition of mitochondrial injury and oxidative stress. Cell Biol Int. 2021;45:839-848 pubmed publisher
Yang L, Liu G, Li X, Xia Z, Wang Y, Lin W, et al. Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis. Cell Death Dis. 2020;11:827 pubmed publisher
Kondo J, Huh W, Franklin J, Heinrich M, Rubin B, Coffey R. A smooth muscle-derived, Braf-driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell-of-origin. J Pathol. 2020;252:441-450 pubmed publisher
Sanches B, Maldarine J, Tamarindo G, Da Silva A, Lima M, Rahal P, et al. Explant culture: A relevant tool for the study of telocytes. Cell Biol Int. 2020;44:2395-2408 pubmed publisher
Li G, Tang X, Zhang S, Jin M, Wang M, Deng Z, et al. SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice. EMBO J. 2020;:e104365 pubmed publisher
Liu J, Qiu P, Qin J, Wu X, Wang X, Yang X, et al. Allogeneic adipose-derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF-1α/IL-10 pathway. Stem Cells. 2020;38:1307-1320 pubmed publisher
Wilkes M, Siva K, Chen J, Varetti G, Youn M, Chae H, et al. Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase. Nat Commun. 2020;11:3344 pubmed publisher
Chen L, Singh S, Muller G, Bornstein S, Kanczkowski W. Transcriptional Analysis of Sepsis-Induced Activation and Damage of the Adrenal Endothelial Microvascular Cells. Front Endocrinol (Lausanne). 2019;10:944 pubmed publisher
Li J, Wang T, Li C, Wang Z, Wang P, Zheng L. Sema3A and HIF1α co-overexpressed iPSC-MSCs/HA scaffold facilitates the repair of calvarial defect in a mouse model. J Cell Physiol. 2020;235:6754-6766 pubmed publisher
Park M, Kim H, Lee H, Zabel B, Bae Y. Novel CD11b+Gr-1+Sca-1+ myeloid cells drive mortality in bacterial infection. Sci Adv. 2020;6:eaax8820 pubmed publisher
Lorenzo Martín L, Bustelo X. In Silico Analysis of the Age-Dependent Evolution of the Transcriptome of Mouse Skin Stem Cells. Cells. 2020;9: pubmed publisher
Kang S, Long K, Wang S, Sada A, Tumbar T. Histone H3 K4/9/27 Trimethylation Levels Affect Wound Healing and Stem Cell Dynamics in Adult Skin. Stem Cell Reports. 2020;14:34-48 pubmed publisher
HWANG C, Marini S, Huber A, Stepien D, Sorkin M, Loder S, et al. Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Res. 2019;7:36 pubmed publisher
Xiong Z, Xia P, Zhu X, Geng J, Wang S, Ye B, et al. Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. J Exp Med. 2020;217: pubmed publisher
Wilkinson A, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo R, et al. Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. Nature. 2019;: pubmed publisher
Meln I, Wolff G, Gajek T, Koddebusch J, Lerch S, Harbrecht L, et al. Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth. Mol Metab. 2019;24:139-148 pubmed publisher
Camps J, Grosemans H, Gijsbers R, Maes C, Sampaolesi M. Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells. Int J Mol Sci. 2019;20: pubmed publisher
Soukup A, Zheng Y, Mehta C, Wu J, Liu P, Cao M, et al. Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer. J Clin Invest. 2019;129:1180-1192 pubmed publisher
Karatepe K, Zhu H, Zhang X, Guo R, Kambara H, Loison F, et al. Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow. Stem Cell Reports. 2018;11:1092-1105 pubmed publisher
Blackshear C, Borrelli M, Shen E, Ransom R, Chung N, Vistnes S, et al. Utilizing Confocal Microscopy to Characterize Human and Mouse Adipose Tissue. Tissue Eng Part C Methods. 2018;: pubmed publisher
Singh K, Camera E, Krug L, Basu A, Pandey R, Munir S, et al. JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin. Nat Commun. 2018;9:3425 pubmed publisher
Wang G, Zhu H, Situ C, Han L, Yu Y, Cheung T, et al. p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells. EMBO J. 2018;37: pubmed publisher
Li Z, Zhang S, Cao L, Li W, Ye Y, Shi Z, et al. Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43. Exp Ther Med. 2018;15:1847-1854 pubmed publisher
Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, et al. Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice. J Biol Chem. 2018;293:1596-1609 pubmed publisher
Yang J, Joshi S, Wang Q, Li P, Wang H, Xiong Y, et al. 14-3-3ζ loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature. Cell Biosci. 2017;7:58 pubmed publisher
Naik S, Larsen S, Gomez N, Alaverdyan K, Sendoel A, Yuan S, et al. Inflammatory memory sensitizes skin epithelial stem cells to tissue damage. Nature. 2017;550:475-480 pubmed publisher
Li X, Yang L, Sun X, Wu J, Li Y, Zhang Q, et al. The role of TGF??HGF?Smad4 axis in regulating the proliferation of mouse airway progenitor cells. Mol Med Rep. 2017;16:8155-8163 pubmed publisher
Joshi S, Yang J, Wang Q, Li P, Wang H, Zhang Q, et al. 14-3-3ζ loss impedes oncogene-induced mammary tumorigenesis and metastasis by attenuating oncogenic signaling. Am J Cancer Res. 2017;7:1654-1664 pubmed
Flores A, Schell J, Krall A, Jelinek D, Miranda M, Grigorian M, et al. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017;19:1017-1026 pubmed publisher
Wang Y, Wang W, Wang X, Wang Y, Wang J, Fu Q, et al. Tissue-engineered sling with adipose-derived stem cells under static mechanical strain. Exp Ther Med. 2017;14:1337-1342 pubmed publisher
Gao S, Zheng G, Wang L, Liang Y, Zhang S, Lao X, et al. Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB. PLoS ONE. 2017;12:e0179248 pubmed publisher
Wang D, Ding X, Xue W, Zheng J, Tian X, Li Y, et al. A new scaffold containing small intestinal submucosa and mesenchymal stem cells improves pancreatic islet function and survival in vitro and in vivo. Int J Mol Med. 2017;39:167-173 pubmed publisher
Barnett F, Rosenfeld M, Wood M, Kiosses W, Usui Y, Marchetti V, et al. Macrophages form functional vascular mimicry channels in vivo. Sci Rep. 2016;6:36659 pubmed publisher
Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, et al. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. J Clin Invest. 2016;126:4537-4553 pubmed publisher
García Mariscal A, Peyrollier K, Basse A, Pedersen E, Ruhl R, van Hengel J, et al. RhoA controls retinoid signaling by ROCK dependent regulation of retinol metabolism. Small Gtpases. 2018;9:433-444 pubmed publisher
Blanco S, Bandiera R, Popis M, Hussain S, Lombard P, Aleksic J, et al. Stem cell function and stress response are controlled by protein synthesis. Nature. 2016;534:335-40 pubmed publisher
Agarwal S, Loder S, Sorkin M, Li S, Shrestha S, Zhao B, et al. Analysis of Bone-Cartilage-Stromal Progenitor Populations in Trauma Induced and Genetic Models of Heterotopic Ossification. Stem Cells. 2016;34:1692-701 pubmed publisher
Frazier T, Bowles A, Lee S, Abbott R, Tucker H, Kaplan D, et al. Serially Transplanted Nonpericytic CD146(-) Adipose Stromal/Stem Cells in Silk Bioscaffolds Regenerate Adipose Tissue In Vivo. Stem Cells. 2016;34:1097-111 pubmed publisher
Loder S, Agarwal S, Sorkin M, Breuler C, Li J, Peterson J, et al. Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification. Ann Surg. 2016;264:1174-1180 pubmed
Rolls A, Pang W, Ibarra I, Colas D, Bonnavion P, Korin B, et al. Sleep disruption impairs haematopoietic stem cell transplantation in mice. Nat Commun. 2015;6:8516 pubmed publisher
Wang B, Zhao L, Fish M, Logan C, Nusse R. Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature. 2015;524:180-5 pubmed publisher
Stitelman D, Brazelton T, Bora A, Traas J, Merianos D, Limberis M, et al. Developmental stage determines efficiency of gene transfer to muscle satellite cells by in utero delivery of adeno-associated virus vector serotype 2/9. Mol Ther Methods Clin Dev. 2014;1:14040 pubmed publisher
Stitelman D, Brazelton T, Endo M, Bora A, Traas J, Zoltick P, et al. Life-Long Transgene Expression in Skeletal Muscle Without Transduction of Satellite Cells Following Embryonic Myogenic Progenitor Transduction by Lentivirus Administered in Utero. Stem Cells Dev. 2015;24:1878-87 pubmed publisher
Mesa K, Rompolas P, Zito G, Myung P, Sun T, Brown S, et al. Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool. Nature. 2015;522:94-7 pubmed publisher
Feng Y, Zhu M, Dangelmajer S, Lee Y, Wijesekera O, Castellanos C, et al. Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer. Cell Death Dis. 2014;5:e1567 pubmed publisher
Ubil E, Duan J, Pillai I, Rosa Garrido M, Wu Y, Bargiacchi F, et al. Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature. 2014;514:585-90 pubmed publisher
Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, et al. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014;211:2119-34 pubmed publisher
Fang J, Barker B, Bolanos L, Liu X, Jerez A, Makishima H, et al. Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network. Cell Rep. 2014;8:1328-38 pubmed publisher
Moding E, Lee C, Castle K, Oh P, Mao L, Zha S, et al. Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. J Clin Invest. 2014;124:3325-38 pubmed publisher
van Berlo J, Kanisicak O, Maillet M, Vagnozzi R, Karch J, Lin S, et al. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014;509:337-41 pubmed publisher
Cosgrove B, Gilbert P, Porpiglia E, Mourkioti F, Lee S, Corbel S, et al. Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nat Med. 2014;20:255-64 pubmed publisher
Peng Y, Levine C, Zahid S, Wilson E, Joyner A. Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration. Proc Natl Acad Sci U S A. 2013;110:20611-6 pubmed publisher
Carofino B, Ayanga B, Justice M. A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013;6:1494-506 pubmed publisher
Adorno M, Sikandar S, Mitra S, Kuo A, Nicolis Di Robilant B, Haro Acosta V, et al. Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature. 2013;501:380-4 pubmed publisher
Zhu B, Smith J, Yarmush M, Nahmias Y, Kirby B, Murthy S. Microfluidic enrichment of mouse epidermal stem cells and validation of stem cell proliferation in vitro. Tissue Eng Part C Methods. 2013;19:765-73 pubmed publisher
Pello O, Chevre R, Laoui D, De Juan A, Lolo F, Andrés Manzano M, et al. In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities. PLoS ONE. 2012;7:e45399 pubmed publisher
Cecchi F, Pajalunga D, Fowler C, Uren A, Rabe D, Peruzzi B, et al. Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling. Cancer Cell. 2012;22:250-62 pubmed publisher
Ding B, Nolan D, Guo P, Babazadeh A, Cao Z, Rosenwaks Z, et al. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell. 2011;147:539-53 pubmed publisher
Alfaro L, Dick S, Siegel A, Anonuevo A, McNagny K, Megeney L, et al. CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration. Stem Cells. 2011;29:2030-41 pubmed publisher
McGee M, Hamner J, Williams R, Rosati S, Sims T, Ng C, et al. Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation. Int J Radiat Oncol Biol Phys. 2010;76:1537-45 pubmed publisher
Kanisicak O, Mendez J, Yamamoto S, Yamamoto M, Goldhamer D. Progenitors of skeletal muscle satellite cells express the muscle determination gene, MyoD. Dev Biol. 2009;332:131-41 pubmed publisher
Park T, Boyd K, Curran T. Cardiovascular and craniofacial defects in Crk-null mice. Mol Cell Biol. 2006;26:6272-82 pubmed
product information
Product Type :
Antibody
Product Name :
CD34 Monoclonal Antibody (RAM34), Alexa Fluor 488, eBioscience
Catalog # :
53-0341-82
Quantity :
100 ug
Price :
US 277.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1.0 ug/test
Species :
Mouse
Clone :
RAM34
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1.0 ug/test
Aliases :
(E3-independent) E2 ubiquitin-conjugating enzyme R1; AU040960; CD34; CD34 antigen; CD34 molecule; CDC34; cell division cycle 34; cell division cycle 34 homolog; cluster designation 34; cluster of differentiation antigen 34; E2 ubiquitin-conjugating enzyme R1; E2-CDC34; hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell marker CD34; Mucosialin; RP11-328D5.2; sialomucin protein; type 1 transmembrane protein; UBC3; UBCH3; UBE2R1; ubiquitin carrier protein; ubiquitin conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA