Sall1 Monoclonal Antibody (NRNSTNX), Alexa Fluor 647, eBioscience | Invitrogen 51-9729-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Sall1 Monoclonal Antibody (NRNSTNX), Alexa Fluor 647, eBioscience

catalog :

51-9729-80

quantity :

25 ug

price :

US 199.00

clonality :

monoclonal

host :

rat

conjugate :

AF647

clone name :

NRNSTNX

reactivity :

mouse

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

Sall1 Monoclonal Antibody (NRNSTNX), Alexa Fluor 647, eBioscience

Catalog # :

51-9729-80

Quantity :

25 ug

Price :

US 199.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 ug/test

Species :

Mouse

Clone :

NRNSTNX

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Sall1, which encodes a zinc finger protein, functions as a transcriptional repressor and interacts physically with histone deacetylase and other components of the chromatin remodeling NuRD complex. It is unknown whether the transcriptional repression is solely dependent on histone deacetylase activity. Gene expression profiling has identified Sall1 as a microglial signature gene. Microglia are the resident macrophages of the central nervous system (CNS). Sall1 is also expressed in abundance in the mesenchyme-derived structure from condensed mesenchyme, S-comma-shaped bodies, to renal tubules and podocytes. Sall1 has been identified as a key transcription factor in self-renewal renal progenitor cells. Sall1 is required to maintain the stemness of nephron progenitor cells by restraining their differentiation into renal vesicles. Defects in SALL1 are the cause of Townes-Brocks syndrome as well as bronchio-oto-renal syndrome. Heterozygous mutations of human SALL1 leading to Townes–Brocks syndrome features dysplastic ears, preaxial polydactyly, imperforate anus, and less commonly, kidney and heart anomalies (Kohlhase et al. 1998). Two transcript variants encoding different isoforms have been found for this gene.

Immunogen :

C-terminal fragment of the protein (aa-805-1322)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test

Aliases :

epididymis secretory protein Li 89; HEL-S-89; HSal1; Msal-3; SAL1; Sal-1; sal-3; SALL1; sal-like 1; sal-like 1 (Drosophila); sal-like protein 1; spalt like transcription factor 1; spalt-like transcription factor 1; TBS; Zinc finger protein 794; zinc finger protein SALL1; Zinc finger protein Spalt-1; zinc finger protein Spalt-3; ZNF794