product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Claudin 1 Polyclonal Antibody
catalog :
51-9000
quantity :
100 µg
price :
US 430
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, chicken, pigs
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 111
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; 1:150; loading ...; fig s1a
  • immunohistochemistry - frozen section; mouse; 1:150; loading ...; fig s1b
Li Y, Wang C, Zhang L, Chen B, Mo Y, Zhang J. Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids Barriers CNS. 2022;19:40 pubmed publisher
  • western blot; human; 1:100; loading ...; fig 5a
Fayad R, Rojas M, Partisani M, Finetti P, Dib S, Abélanet S, et al. EFA6B regulates a stop signal for collective invasion in breast cancer. Nat Commun. 2021;12:2198 pubmed publisher
  • western blot; mouse; 0.5 ug/ml; loading ...; fig 6k
Break T, Oikonomou V, Dutzan N, Desai J, Swidergall M, Freiwald T, et al. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021;371: pubmed publisher
  • immunohistochemistry; human; 1:200; loading ...; fig 3c
Pellegrini L, Bonfio C, Chadwick J, Begum F, Skehel M, Lancaster M. Human CNS barrier-forming organoids with cerebrospinal fluid production. Science. 2020;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 6a
  • western blot; mouse; 1:200; loading ...; fig 6b
Cox C, Lu R, Salcin K, Wilson J. The Endosomal Protein Endotubin Is Required for Enterocyte Differentiation. Cell Mol Gastroenterol Hepatol. 2018;5:145-156 pubmed publisher
  • immunocytochemistry; dogs; fig 2
  • western blot; dogs; fig 2
Tokuda S, Hirai T, Furuse M. Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells. PLoS ONE. 2017;12:e0182521 pubmed publisher
  • western blot; human; loading ...; fig 1b
Mathieu A, Ohl Séguy E, Dubois M, Jean D, Jones C, Boudreau F, et al. Subcellular proteomics analysis of different stages of colorectal cancer cell lines. Proteomics. 2016;16:3009-3018 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig s1d
Balusu S, Van Wonterghem E, De Rycke R, Raemdonck K, Stremersch S, Gevaert K, et al. Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles. EMBO Mol Med. 2016;8:1162-1183 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
  • western blot; human; fig 1
Yuki T, Tobiishi M, Kusaka Kikushima A, Ota Y, Tokura Y. Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17. PLoS ONE. 2016;11:e0161759 pubmed publisher
  • western blot; mouse; 1:50; loading ...; fig 4j
Wardill H, Bowen J, Van Sebille Y, Secombe K, Coller J, Ball I, et al. TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced Diarrhea. Mol Cancer Ther. 2016;15:2767-2779 pubmed
  • western blot; dogs; 1:1000; fig 3a
Ronaghan N, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, et al. The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction. Am J Physiol Gastrointest Liver Physiol. 2016;311:G466-79 pubmed publisher
  • immunocytochemistry; human; fig 5
Maria O, Liu Y, El Hakim M, Zeitouni A, Tran S. The role of human fibronectin- or placenta basement membrane extract-based gels in favouring the formation of polarized salivary acinar-like structures. J Tissue Eng Regen Med. 2017;11:2643-2657 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 2
Zoschke C, Ulrich M, Sochorová M, Wolff C, Vavrova K, Ma N, et al. The barrier function of organotypic non-melanoma skin cancer models. J Control Release. 2016;233:10-8 pubmed publisher
  • western blot; pigs ; 1:1000; loading ...; tbl 6
Zhu H, Liu Y, Chen S, Wang X, Pi D, Leng W, et al. Fish oil enhances intestinal barrier function and inhibits corticotropin-releasing hormone/corticotropin-releasing hormone receptor 1 signalling pathway in weaned pigs after lipopolysaccharide challenge. Br J Nutr. 2016;115:1947-57 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 2
Kacem M, Agili F, Tounsi H, Zribi H, Zaraa I, Mokni M, et al. Immunohistological study of tight junction protein expression in mal de Meleda. Ultrastruct Pathol. 2016;40:176-80 pubmed publisher
  • western blot; human; 1:500; fig 3
Patkee W, Carr G, Baker E, Baines D, Garnett J. Metformin prevents the effects of Pseudomonas aeruginosa on airway epithelial tight junctions and restricts hyperglycaemia-induced bacterial growth. J Cell Mol Med. 2016;20:758-64 pubmed publisher
  • immunocytochemistry; mouse; 5 ug/ml; fig 2
Lazarevic I, Engelhardt B. Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier. Fluids Barriers CNS. 2016;13:2 pubmed publisher
  • immunocytochemistry; rat; 1:100; fig 1
  • western blot; rat; 1:1000; fig 3
Yang S, Krug S, Heitmann J, Hu L, Reinhold A, Sauer S, et al. Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier. Biomaterials. 2016;82:20-33 pubmed publisher
  • western blot; human; fig 1c
Barbáchano A, Fernández Barral A, Pereira F, Segura M, Ordóñez Morán P, Carrillo de Santa Pau E, et al. SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. Oncogene. 2016;35:2991-3003 pubmed publisher
  • western blot; chicken; 1:1000
Liu S, Zhao J, Fan X, Liu G, Jiao H, Wang X, et al. Rapamycin, a specific inhibitor of the target of rapamycin complex 1, disrupts intestinal barrier integrity in broiler chicks. J Anim Physiol Anim Nutr (Berl). 2016;100:323-30 pubmed publisher
Kolli U, Jalodia R, Moidunny S, Singh P, Ban Y, Tao J, et al. Multi-omics analysis revealing the interplay between gut microbiome and the host following opioid use. Gut Microbes. 2023;15:2246184 pubmed publisher
Huang C, Yue Q, Sun L, Di K, Yang D, Hao E, et al. Restorative effects of Lactobacillus rhamnosus LR-32 on the gut microbiota, barrier integrity, and 5-HT metabolism in reducing feather-pecking behavior in laying hens with antibiotic-induced dysbiosis. Front Microbiol. 2023;14:1173804 pubmed publisher
Wittner L, Wagener L, Wiese J, Stolzer I, Krug S, Naschberger E, et al. Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing. Int J Mol Sci. 2023;24: pubmed publisher
Nakazawa T, Hasegawa A, Nagasaka T, Yoshida K, Guo F, Wu D, et al. Differential Expression of Claudin 1 and 4 in Basal Cell Carcinoma of the Skin. Dermatol Res Pract. 2023;2023:9936551 pubmed publisher
Awad K, Barmeyer C, Bojarski C, Nagel O, Lee I, Schweiger M, et al. Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M). Cells. 2023;12: pubmed publisher
Brunner N, Stein L, Amasheh S. Cellular Distribution Pattern of tjp1 (ZO-1) in Xenopus laevis Oocytes Heterologously Expressing Claudins. J Membr Biol. 2023;256:51-61 pubmed publisher
Bekusova V, Zudova T, Fatyykhov I, Fedorova A, Amasheh S, Markov A. Selective Role of TNFα and IL10 in Regulation of Barrier Properties of the Colon in DMH-Induced Tumor and Healthy Rats. Int J Mol Sci. 2022;23: pubmed publisher
Haas A, Zihni C, Krug S, Maraspini R, Otani T, Furuse M, et al. ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions. Cells. 2022;11: pubmed publisher
Hollis P, Mobley R, Bhuju J, Abell A, Sutter C, Sutter T. CYP1B1 Augments the Mesenchymal, Claudin-Low, and Chemoresistant Phenotypes of Triple-Negative Breast Cancer Cells. Int J Mol Sci. 2022;23: pubmed publisher
Shi H, Yin Z, Koronyo Y, Fuchs D, Sheyn J, Davis M, et al. Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia. Acta Neuropathol Commun. 2022;10:136 pubmed publisher
Xia B, Zhong R, Wu W, Luo C, Meng Q, Gao Q, et al. Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model. Microbiome. 2022;10:139 pubmed publisher
Delgado Diaz D, Jesaveluk B, Hayward J, Tyssen D, Alisoltani A, Potgieter M, et al. Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression. Microbiome. 2022;10:141 pubmed publisher
Moran M, Pope E, Brewer M, Beck L. Supply Chain Disruptions During COVID-19 Pandemic Uncover Differences in Keratinocyte Culture Media. JID Innov. 2022;2:100151 pubmed publisher
Hasegawa K, Sakamaki Y, Tamaki M, Wakino S. Nicotinamide mononucleotide ameliorates adriamycin-induced renal damage by epigenetically suppressing the NMN/NAD consumers mediated by Twist2. Sci Rep. 2022;12:13712 pubmed publisher
Deissler H, Busch C, Wolf A, Rehak M. Beovu, but not Lucentis impairs the function of the barrier formed by retinal endothelial cells in vitro. Sci Rep. 2022;12:12493 pubmed publisher
Reinhold A, Krug S, Salvador E, Sauer R, Karl Sch xf6 ller F, Malcangio M, et al. MicroRNA-21-5p functions via RECK/MMP9 as a proalgesic regulator of the blood nerve barrier in nerve injury. Ann N Y Acad Sci. 2022;1515:184-195 pubmed publisher
Deissler H, Rehak M, Wolf A. Impairment of the Retinal Endothelial Cell Barrier Induced by Long-Term Treatment with VEGF-A165 No Longer Depends on the Growth Factor's Presence. Biomolecules. 2022;12: pubmed publisher
Wei xdf F, Czichos C, Knobe L, Voges L, Bojarski C, Michel G, et al. MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating Effects during Colitis Indirectly Stabilizing the Intestinal Barrier. Cells. 2022;11: pubmed publisher
Ishikawa S, Nikaido M, Otani T, Ogata K, Iida H, Inai Y, et al. Inhibition of retinoid X receptor improved the morphology, localization of desmosomal proteins and paracellular permeability in three-dimensional cultures of mouse keratinocytes. Microscopy (Oxf). 2022;71:152-160 pubmed publisher
Kinoshita N, Yamamoto T, Yasue N, Takagi C, Fujimori T, Ueno N. Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to cell-cell adhesion through enhancing tight junctions. iScience. 2022;25:103846 pubmed publisher
Xia B, Wu W, Fang W, Wen X, Xie J, Zhang H. Heat stress-induced mucosal barrier dysfunction is potentially associated with gut microbiota dysbiosis in pigs. Anim Nutr. 2022;8:289-299 pubmed publisher
Liu G, Xu X, Wu C, Jia G, Zhao H, Chen X, et al. Spermine protects intestinal barrier integrity through ras-related C3 botulinum toxin substrate 1/phospholipase C-γ1 signaling pathway in piglets. Anim Nutr. 2022;8:135-143 pubmed publisher
Yang Y, Fan X, Ji Y, Li J, Dai Z, Wu Z. Glycine represses endoplasmic reticulum stress-related apoptosis and improves intestinal barrier by activating mammalian target of rapamycin complex 1 signaling. Anim Nutr. 2022;8:1-9 pubmed publisher
Edechi C, Amini M, Hamedani M, Terceiro L, Nickel B, Leygue E, et al. Comparison of Fixation Methods for the Detection of Claudin 1 and E-Cadherin in Breast Cancer Cell Lines by Immunofluorescence. J Histochem Cytochem. 2022;70:181-187 pubmed publisher
Cohen Barak E, Azzam W, Koetsier J, Danial Farran N, Barcan M, Hriesh M, et al. Acral peeling in Nagashima type palmo-plantar keratosis patients reveals the role of serine protease inhibitor B 7 in keratinocyte adhesion. Exp Dermatol. 2022;31:214-222 pubmed publisher
Moran M, Pandya R, Leffler K, Yoshida T, Beck L, Brewer M. Characterization of Human Keratinocyte Cell Lines for Barrier Studies. JID Innov. 2021;1:100018 pubmed publisher
Reyes Nicolás V, Allaire J, Alfonso A, Pupo Gómez D, Pomerleau V, Giroux V, et al. Altered Mucus Barrier Integrity and Increased Susceptibility to Colitis in Mice upon Loss of Telocyte Bone Morphogenetic Protein Signalling. Cells. 2021;10: pubmed publisher
Bony B, Tarudji A, Miller H, Gowrikumar S, Roy S, Curtis E, et al. Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood-Brain Barrier. ACS Nano. 2021;15:18520-18531 pubmed publisher
Yen T, Jiang R, Chang C, Wu C, Liang K. Erythromycin reduces nasal inflammation by inhibiting immunoglobulin production, attenuating mucus secretion, and modulating cytokine expression. Sci Rep. 2021;11:21737 pubmed publisher
MARCHELLETTA R, Krishnan M, Spalinger M, Placone T, Alvarez R, Sayoc Becerra A, et al. T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling. J Clin Invest. 2021;131: pubmed publisher
Meloni M, Buratti P, Carriero F, Ceriotti L. In Vitro Modelling of Barrier Impairment Associated with Gastro-Oesophageal Reflux Disease (GERD). Clin Exp Gastroenterol. 2021;14:361-373 pubmed publisher
Droessler L, Cornelius V, Markov A, Amasheh S. Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1. Int J Mol Sci. 2021;22: pubmed publisher
Wu B, Zhou Q, He Z, Wang X, Sun X, Chen Y. Protective Effect of the Abelmoschus manihot Flower Extract on DSS-Induced Ulcerative Colitis in Mice. Evid Based Complement Alternat Med. 2021;2021:7422792 pubmed publisher
Broussard J, Koetsier J, Hegazy M, Green K. Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function. Curr Biol. 2021;31:3275-3291.e5 pubmed publisher
Park S, Jang H, Kim S, Kim D, Park Y, Kee S. Expression of E-Cadherin in Epithelial Cancer Cells Increases Cell Motility and Directionality through the Localization of ZO-1 during Collective Cell Migration. Bioengineering (Basel). 2021;8: pubmed publisher
Huang X, Oshima T, Tomita T, Fukui H, Miwa H. Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels. Biology (Basel). 2021;10: pubmed publisher
Yasuda I, Hasegawa K, Sakamaki Y, Muraoka H, Kawaguchi T, Kusahana E, et al. Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy. J Am Soc Nephrol. 2021;32:1355-1370 pubmed publisher
Kumamoto J, Fujimoto K, Kobayashi Y, Ohno K, Nagayama M, Denda M. Substrate membrane bearing close-packed array of micron-level pillars incrassates air-exposed three-dimensional epidermal equivalent model. Skin Res Technol. 2021;27:863-870 pubmed publisher
Kakiuchi A, Kakuki T, Ohwada K, Kurose M, Kondoh A, Obata K, et al. HDAC inhibitors suppress the proliferation, migration and invasiveness of human head and neck squamous cell carcinoma cells via p63‑mediated tight junction molecules and p21‑mediated growth arrest. Oncol Rep. 2021;45: pubmed publisher
Buzhdygan T, Rodrigues C, McGary H, Khan J, Andrews A, Rawls S, et al. The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties. J Neuroinflammation. 2021;18:63 pubmed publisher
Jia H, Zhang Y, Si X, Jin Y, Jiang D, Dai Z, et al. Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes. Nutrients. 2021;13: pubmed publisher
Liu Y, Xu Q, Wang Y, Liang T, Li X, Wang D, et al. Necroptosis is active and contributes to intestinal injury in a piglet model with lipopolysaccharide challenge. Cell Death Dis. 2021;12:62 pubmed publisher
Pastushenko I, Mauri F, Song Y, De Cock F, Meeusen B, Swedlund B, et al. Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis. Nature. 2021;589:448-455 pubmed publisher
Winkler L, Blasig R, Breitkreuz Korff O, Berndt P, Dithmer S, Helms H, et al. Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins. J Cereb Blood Flow Metab. 2021;41:132-145 pubmed publisher
Shi H, Koronyo Y, Fuchs D, Sheyn J, Wawrowsky K, Lahiri S, et al. Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease. Acta Neuropathol Commun. 2020;8:202 pubmed publisher
Cui J, Shipley F, Shannon M, Alturkistani O, Dani N, Webb M, et al. Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation. Dev Cell. 2020;55:617-628.e6 pubmed publisher
Uc P, Miranda J, Raya Sandino A, Alarcón L, Roldán M, Ocadiz Delgado R, et al. E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions. Int J Oncol. 2020;57:905-924 pubmed publisher
Aragona M, Sifrim A, Malfait M, Song Y, Van Herck J, Dekoninck S, et al. Mechanisms of stretch-mediated skin expansion at single-cell resolution. Nature. 2020;584:268-273 pubmed publisher
Chen Z, Chen G, Zhao H. FDPS promotes glioma growth and macrophage recruitment by regulating CCL20 via Wnt/β-catenin signalling pathway. J Cell Mol Med. 2020;24:9055-9066 pubmed publisher
Jäckle A, Ziemssen F, Kuhn E, Kampmeier J, Lang G, Lang G, et al. Sitagliptin and the Blood-Retina Barrier: Effects on Retinal Endothelial Cells Manifested Only after Prolonged Exposure. J Diabetes Res. 2020;2020:2450781 pubmed publisher
da Cruz Silva L, de Oliveira W, Pereira N, Halpern I, Tanabe C, Mattos M, et al. Claudin expression profile in flat wart and cutaneous squamous cell carcinoma in epidermodysplasia verruciformis. Sci Rep. 2020;10:9268 pubmed publisher
Bishehsari F, Preuss F, Mirbagheri S, Zhang L, Shaikh M, Keshavarzian A. Interaction of alcohol with time of eating on markers of circadian dyssynchrony and colon tissue injury. Chem Biol Interact. 2020;325:109132 pubmed publisher
Ito N, Sakamoto K, Hikichi C, Matsusaka T, Nagata M. Biphasic MIF and SDF1 expression during podocyte injury promote CD44-mediated glomerular parietal cell migration in focal segmental glomerulosclerosis. Am J Physiol Renal Physiol. 2020;318:F741-F753 pubmed publisher
Chen L, Feng Z, Yuan G, Emerson C, Stewart P, Ye F, et al. Human Immunodeficiency Virus-Associated Exosomes Promote Kaposi's Sarcoma-Associated Herpesvirus Infection via the Epidermal Growth Factor Receptor. J Virol. 2020;94: pubmed publisher
Su L, Wang Z, Xie S, Hu D, Cheng Y, Mruk D, et al. Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization. J Cell Physiol. 2020;235:6127-6138 pubmed publisher
Lux T, Hu X, Ben Kraiem A, Blum R, Chen J, Rittner H. Regional Differences in Tight Junction Protein Expression in the Blood-DRG Barrier and Their Alterations after Nerve Traumatic Injury in Rats. Int J Mol Sci. 2019;21: pubmed publisher
Sayoc Becerra A, Krishnan M, Fan S, Jimenez J, HERNANDEZ R, Gibson K, et al. The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction. Inflamm Bowel Dis. 2020;26:407-422 pubmed publisher
Mehdizadeh Gohari I, Li J, Navarro M, Uzal F, McClane B. Effects of Claudin-1 on the Action of Clostridium perfringens Enterotoxin in Caco-2 Cells. Toxins (Basel). 2019;11: pubmed publisher
Miranda J, Martín Tapia D, Valdespino Vazquez Y, Alarcón L, Espejel Nuñez A, Guzmán Huerta M, et al. Syncytiotrophoblast of Placentae from Women with Zika Virus Infection Has Altered Tight Junction Protein Expression and Increased Paracellular Permeability. Cells. 2019;8: pubmed publisher
Dan Q, Shi Y, Rabani R, Venugopal S, Xiao J, Anwer S, et al. Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells. J Biol Chem. 2019;294:15446-15465 pubmed publisher
Otani T, Nguyen T, Tokuda S, Sugihara K, Sugawara T, Furuse K, et al. Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity. J Cell Biol. 2019;218:3372-3396 pubmed publisher
Yang R, Hui Q, Jiang Q, Liu S, Zhang H, Wu J, et al. Effect of Manitoba-Grown Red-Osier Dogwood Extracts on Recovering Caco-2 Cells from H2O2-Induced Oxidative Damage. Antioxidants (Basel). 2019;8: pubmed publisher
Amaya E, Alarcón L, Martín Tapia D, Cuellar Perez F, Cano Cortina M, Ortega Olvera J, et al. Activation of the Ca2+ sensing receptor and the PKC/WNK4 downstream signaling cascade induces incorporation of ZO-2 to tight junctions and its separation from 14-3-3. Mol Biol Cell. 2019;30:2377-2398 pubmed publisher
Masterson J, Biette K, Hammer J, Nguyen N, Capocelli K, Saeedi B, et al. Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis. J Clin Invest. 2019;129:3224-3235 pubmed publisher
Luo Y, Xu J, Zhang C, Jiang C, Ma Y, He H, et al. Toll-like receptor 5-mediated IL-17C expression in intestinal epithelial cells enhances epithelial host defense against F4+ ETEC infection. Vet Res. 2019;50:48 pubmed publisher
Moonwiriyakit A, Koval M, Muanprasat C. Pharmacological stimulation of G-protein coupled receptor 40 alleviates cytokine-induced epithelial barrier disruption in airway epithelial Calu-3 cells. Int Immunopharmacol. 2019;73:353-361 pubmed publisher
Reinhold A, Schwabe J, Lux T, Salvador E, Rittner H. Quantitative and Microstructural Changes of the Blood-Nerve Barrier in Peripheral Neuropathy. Front Neurosci. 2018;12:936 pubmed publisher
Zhang L, Wang X, Chen S, Wang S, Tu Z, Zhang G, et al. Medium-Chain Triglycerides Attenuate Liver Injury in Lipopolysaccharide-Challenged Pigs by Inhibiting Necroptotic and Inflammatory Signaling Pathways. Int J Mol Sci. 2018;19: pubmed publisher
Deissler H, Lang G, Lang G. Fate of the Fc fusion protein aflibercept in retinal endothelial cells: competition of recycling and degradation. Graefes Arch Clin Exp Ophthalmol. 2019;257:83-94 pubmed publisher
Bashir M, Meddings J, Alshaikh A, Jung D, Le K, Amin R, et al. Enhanced gastrointestinal passive paracellular permeability contributes to the obesity-associated hyperoxaluria. Am J Physiol Gastrointest Liver Physiol. 2019;316:G1-G14 pubmed publisher
Jin Y, Ibrahim D, Magness S, Blikslager A. Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity. Am J Physiol Gastrointest Liver Physiol. 2018;315:G966-G979 pubmed publisher
Tawiah A, Moreau F, Kumar M, Tiwari S, Falguera J, Chadee K. High MUC2 Mucin Biosynthesis in Goblet Cells Impedes Restitution and Wound Healing by Elevating Endoplasmic Reticulum Stress and Altered Production of Growth Factors. Am J Pathol. 2018;188:2025-2041 pubmed publisher
Xu X, Chen S, Wang H, Tu Z, Wang S, Wang X, et al. Medium-chain TAG improve intestinal integrity by suppressing toll-like receptor 4, nucleotide-binding oligomerisation domain proteins and necroptosis signalling in weanling piglets challenged with lipopolysaccharide. Br J Nutr. 2018;119:1019-1028 pubmed publisher
Riva L, Song O, Prentoe J, Helle F, L homme L, Gattolliat C, et al. Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry. J Virol. 2018;92: pubmed publisher
Steeland S, Gorlé N, Vandendriessche C, Balusu S, Brkic M, Van Cauwenberghe C, et al. Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease. EMBO Mol Med. 2018;10: pubmed publisher
Yamaga K, Murota H, Tamura A, Miyata H, Ohmi M, Kikuta J, et al. Claudin-3 Loss Causes Leakage of Sweat from the Sweat Gland to Contribute to the Pathogenesis of Atopic Dermatitis. J Invest Dermatol. 2018;138:1279-1287 pubmed publisher
Cuellar P, Hernández Nava E, García Rivera G, Chavez Munguia B, Schnoor M, Betanzos A, et al. Entamoeba histolytica EhCP112 Dislocates and Degrades Claudin-1 and Claudin-2 at Tight Junctions of the Intestinal Epithelium. Front Cell Infect Microbiol. 2017;7:372 pubmed publisher
Sauer R, Kirchner J, Yang S, Hu L, Leinders M, Sommer C, et al. Blood-spinal cord barrier breakdown and pericyte deficiency in peripheral neuropathy. Ann N Y Acad Sci. 2017;1405:71-88 pubmed publisher
Zhu H, Pi D, Leng W, Wang X, HU C, Hou Y, et al. Asparagine preserves intestinal barrier function from LPS-induced injury and regulates CRF/CRFR signaling pathway. Innate Immun. 2017;23:546-556 pubmed publisher
Kern M, Günzel D, Aschenbach J, Tedin K, Bondzio A, Lodemann U. Altered Cytokine Expression and Barrier Properties after In Vitro Infection of Porcine Epithelial Cells with Enterotoxigenic Escherichia coli and Probiotic Enterococcus faecium. Mediators Inflamm. 2017;2017:2748192 pubmed publisher
Nighot P, Leung L, Ma T. Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin. Exp Cell Res. 2017;352:113-122 pubmed publisher
Martínez Revollar G, Garay E, Martín Tapia D, Nava P, Huerta M, Lopez Bayghen E, et al. Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways. Exp Cell Res. 2015;339:67-80 pubmed publisher
Baruch K, Rosenzweig N, Kertser A, Deczkowska A, Sharif A, Spinrad A, et al. Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology. Nat Commun. 2015;6:7967 pubmed publisher
Goichon A, Bertrand J, Chan P, Lecleire S, Coquard A, Cailleux A, et al. Enteral delivery of proteins enhances the expression of proteins involved in the cytoskeleton and protein biosynthesis in human duodenal mucosa. Am J Clin Nutr. 2015;102:359-67 pubmed publisher
Lu Z, Kim D, Fan J, Lu Q, Verbanac K, Ding L, et al. A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment. Mol Cancer. 2015;14:120 pubmed publisher
Staat C, Coisne C, Dabrowski S, Stamatovic S, Andjelkovic A, Wolburg H, et al. Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers. Biomaterials. 2015;54:9-20 pubmed publisher
Ghersi Egea J, Babikian A, Blondel S, Strazielle N. Changes in the cerebrospinal fluid circulatory system of the developing rat: quantitative volumetric analysis and effect on blood-CSF permeability interpretation. Fluids Barriers CNS. 2015;12:8 pubmed publisher
Tokuda S, Furuse M. Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells. PLoS ONE. 2015;10:e0119869 pubmed publisher
Watari A, Hashegawa M, Yagi K, Kondoh M. Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers. Eur J Pharm Biopharm. 2015;89:232-8 pubmed publisher
Casselbrant A, Elias E, Fändriks L, Wallenius V. Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2015;11:45-53 pubmed publisher
Retana C, Sanchez E, Perez Lopez A, Cruz A, Lagunas J, Cruz C, et al. Alterations of intercellular junctions in peritoneal mesothelial cells from patients undergoing dialysis: effect of retinoic Acid. Perit Dial Int. 2015;35:275-87 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Claudin 1 Polyclonal Antibody
Catalog # :
51-9000
Quantity :
100 µg
Price :
US 430
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Chicken, Human, Rat
Applications :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 0.25 - 2 µg/mL
Species :
Chicken, Human, Rat
Isotype :
IgG
Storage :
-20°C
Description :
Claudin-1 is a member of the transmembrane protein family claudins located in cell-cell tight junctions and it acts as a co-receptor for HCV entry into hepatic cells. Claudins are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Claudin-1 is expressed in most tissues such as bladder, fallopian tube, liver, pancreas, prostate, and skin.
Immunogen :
Synthetic peptide derived from the C-terminus of the human Claudin-1 protein
Format :
Liquid
Applications w/Dilutions :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 0.25 - 2 µg/mL
Aliases :
AI596271; claudin 1; claudin-1; CLD1; CLDN1; hypothetical protein; ILVASC; SEMP1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1; tight junction protein; UNQ481/PRO944
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA