Estrogen Receptor beta Polyclonal Antibody | Invitrogen 51-7700 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Estrogen Receptor beta Polyclonal Antibody

catalog :

51-7700

quantity :

100 µg

price :

US 400

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; mouse; loading ...; fig 3b	Yuan B, Yang J, Dubeau L, Hu Y, Li R. A Phosphotyrosine Switch in Estrogen Receptor β Is Required for Mouse Ovarian Function. Front Cell Dev Biol. 2021;9:649087 pubmed publisher
flow cytometry; bovine; 1:50; fig 6	Medina Estrada I, López Meza J, Ochoa Zarzosa A. Anti-Inflammatory and Antimicrobial Effects of Estradiol in Bovine Mammary Epithelial Cells during Staphylococcus aureus Internalization. Mediators Inflamm. 2016;2016:6120509 pubmed publisher
immunocytochemistry; mouse; fig 1 western blot; mouse; fig 1	Pedram A, Razandi M, Blumberg B, Levin E. Membrane and nuclear estrogen receptor Î± collaborate to suppress adipogenesis but not triglyceride content. FASEB J. 2016;30:230-40 pubmed publisher
	Bado I, Pham E, Soibam B, Nikolos F, Gustafsson J, Thomas C. ERβ alters the chemosensitivity of luminal breast cancer cells by regulating p53 function. Oncotarget. 2018;9:22509-22522 pubmed publisher
	Novaira H, Graceli J, Capellino S, Schoeffield A, Hoffman G, Wolfe A, et al. Development and Characterization of Novel Rat Anti-mER? Sera. Endocrinology. 2016;157:2844-52 pubmed publisher
	Bean L, Kumar A, Rani A, Guidi M, Rosario A, Cruz P, et al. Re-Opening the Critical Window for Estrogen Therapy. J Neurosci. 2015;35:16077-93 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Estrogen Receptor beta Polyclonal Antibody

Catalog # :

51-7700

Quantity :

100 µg

Price :

US 400

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: 1.0 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 1-2 µg/mL

Species :

Human

Isotype :

IgG

Storage :

-20°C

Description :

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.

Immunogen :

A 19 amino acid synthetic peptide derived from the C-terminus of the human Estrogen Receptor-beta protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1.0 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 1-2 µg/mL

Aliases :

ER; ER beta; ER[b]; Erb; Erb2; Erbeta; ER-beta; Esr2; ESRB; ESR-BETA; ESTRB; estrogen receptor 2; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; estrogen receptor beta 1 isoform deletion variant; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor

more info or order :

Invitrogen product webpage