| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - frozen section; mouse; 1:125; loading ...; fig 4d
- western blot; mouse; 1:1000; loading ...; fig 4a
| Marincola Smith P, Choksi Y, Markham N, Hanna D, Zi J, Weaver C, et al. Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice. Am J Physiol Gastrointest Liver Physiol. 2021;320:G936-G957 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 6a
- western blot; mouse; 1:500; loading ...; fig 6b
| Cox C, Lu R, Salcin K, Wilson J. The Endosomal Protein Endotubin Is Required for Enterocyte Differentiation. Cell Mol Gastroenterol Hepatol. 2018;5:145-156 pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig 2d
| Samuel W, Jaworski C, Postnikova O, Kutty R, Duncan T, Tan L, et al. Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells. Mol Vis. 2017;23:60-89 pubmed |
- immunocytochemistry; human; loading ...; fig 5b
- western blot; human; loading ...; fig 5a
| Zhang C, Yan J, Xiao Y, Shen Y, Wang J, Ge W, et al. Inhibition of Autophagic Degradation Process Contributes to Claudin-2 Expression Increase and Epithelial Tight Junction Dysfunction in TNF-α Treated Cell Monolayers. Int J Mol Sci. 2017;18: pubmed publisher |
- flow cytometry; human; 1:200; loading ...; fig 3a
| Torres Martínez A, Gallardo Vera J, Lara Holguin A, Montano L, Rendón Huerta E. Claudin-6 enhances cell invasiveness through claudin-1 in AGS human adenocarcinoma gastric cancer cells. Exp Cell Res. 2017;350:226-235 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 2b
| Lepage D, Bélanger É, Jones C, Tremblay S, Allaire J, Bruneau J, et al. Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury. Sci Rep. 2016;6:36776 pubmed publisher |
- immunocytochemistry; dogs; loading ...; fig 7a
- western blot; dogs; loading ...; fig 1b
- western blot; human; fig 1a
| Fujii N, Matsuo Y, Matsunaga T, Endo S, Sakai H, Yamaguchi M, et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells. J Biol Chem. 2016;291:24787-24799 pubmed |
- western blot; dogs; 1:1000
| Ronaghan N, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, et al. The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction. Am J Physiol Gastrointest Liver Physiol. 2016;311:G466-79 pubmed publisher |
- immunocytochemistry; human; fig 5
- western blot; human; fig 7
| Maria O, Liu Y, El Hakim M, Zeitouni A, Tran S. The role of human fibronectin- or placenta basement membrane extract-based gels in favouring the formation of polarized salivary acinar-like structures. J Tissue Eng Regen Med. 2017;11:2643-2657 pubmed publisher |
- immunohistochemistry - paraffin section; domestic horse; fig 3
- western blot; domestic horse; 1:1000; fig 1
| Lee B, Kang H, Lee D, Ahn C, Jeung E. Claudin-1, -2, -4, and -5: comparison of expression levels and distribution in equine tissues. J Vet Sci. 2016;17:445-451 pubmed publisher |
- immunocytochemistry; mouse; fig 3
| Strazielle N, Creidy R, Malcus C, Boucraut J, Ghersi Egea J. T-Lymphocytes Traffic into the Brain across the Blood-CSF Barrier: Evidence Using a Reconstituted Choroid Plexus Epithelium. PLoS ONE. 2016;11:e0150945 pubmed publisher |
- immunocytochemistry; mouse; 10 ug/ml; fig 2
| Lazarevic I, Engelhardt B. Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier. Fluids Barriers CNS. 2016;13:2 pubmed publisher |
- western blot; human; fig 2
| Phillips S, Soderblom E, Bradrick S, Garcia Blanco M. Identification of Proteins Bound to Dengue Viral RNA In Vivo Reveals New Host Proteins Important for Virus Replication. MBio. 2016;7:e01865-15 pubmed publisher |
| Higashi T, Stephenson R, Schwayer C, Huljev K, Higashi A, Heisenberg C, et al. Zinc-based Ultrasensitive Microscopic Barrier Assay (ZnUMBA): a live imaging method to detect local barrier breaches. J Cell Sci. 2023;: pubmed publisher |
| Lonati E, Sala G, Corbetta P, Pagliari S, Cazzaniga E, Botto L, et al. Digested Cinnamon (Cinnamomum verum J. Presl) Bark Extract Modulates Claudin-2 Gene Expression and Protein Levels under TNFα/IL-1β Inflammatory Stimulus. Int J Mol Sci. 2023;24: pubmed publisher |
| Wittner L, Wagener L, Wiese J, Stolzer I, Krug S, Naschberger E, et al. Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing. Int J Mol Sci. 2023;24: pubmed publisher |
| Mukherji S, Brambilla L, Stuart K, Mayes I, Kutz L, Chen Y, et al. Na/K-ATPase signaling tonically inhibits sodium reabsorption in the renal proximal tubule. FASEB J. 2023;37:e22835 pubmed publisher |
| Awad K, Barmeyer C, Bojarski C, Nagel O, Lee I, Schweiger M, et al. Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M). Cells. 2023;12: pubmed publisher |
| Higashi T, Saito A, Fukazawa Y, Furuse M, Higashi A, Ono M, et al. EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier. J Cell Biol. 2023;222: pubmed publisher |
| Pan M, Barua N, Ip M. Mucin-degrading gut commensals isolated from healthy faecal donor suppress intestinal epithelial inflammation and regulate tight junction barrier function. Front Immunol. 2022;13:1021094 pubmed publisher |
| Gonschior H, Schmied C, Van der Veen R, Eichhorst J, Himmerkus N, Piontek J, et al. Nanoscale segregation of channel and barrier claudins enables paracellular ion flux. Nat Commun. 2022;13:4985 pubmed publisher |
| Koumangoye R, Penny P, Delpire E. Loss of NKCC1 function increases epithelial tight junction permeability by upregulating claudin-2 expression. Am J Physiol Cell Physiol. 2022;323:C1251-C1263 pubmed publisher |
| Scalavino V, Piccinno E, Bianco G, Schena N, Armentano R, Giannelli G, et al. The Increase of miR-195-5p Reduces Intestinal Permeability in Ulcerative Colitis, Modulating Tight Junctions' Expression. Int J Mol Sci. 2022;23: pubmed publisher |
| Wei xdf F, Czichos C, Knobe L, Voges L, Bojarski C, Michel G, et al. MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating Effects during Colitis Indirectly Stabilizing the Intestinal Barrier. Cells. 2022;11: pubmed publisher |
| Scalavino V, Piccinno E, Lacalamita A, Tafaro A, Armentano R, Giannelli G, et al. miR-195-5p Regulates Tight Junctions Expression via Claudin-2 Downregulation in Ulcerative Colitis. Biomedicines. 2022;10: pubmed publisher |
| Reyes Nicolás V, Allaire J, Alfonso A, Pupo Gómez D, Pomerleau V, Giroux V, et al. Altered Mucus Barrier Integrity and Increased Susceptibility to Colitis in Mice upon Loss of Telocyte Bone Morphogenetic Protein Signalling. Cells. 2021;10: pubmed publisher |
| Beggs M, Young K, Pan W, O Neill D, Saurette M, Plain A, et al. Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
| Ito A, Nasako H, Akizuki R, Takashina Y, Eguchi H, Matsunaga T, et al. Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal. Int J Mol Sci. 2021;22: pubmed publisher |
| Muntjewerff E, Tang K, Lutter L, Christoffersson G, Nicolasen M, Gao H, et al. Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides. Acta Physiol (Oxf). 2021;232:e13655 pubmed publisher |
| Eguchi H, Matsunaga H, Onuma S, Yoshino Y, Matsunaga T, Ikari A. Down-Regulation of Claudin-2 Expression by Cyanidin-3-Glucoside Enhances Sensitivity to Anticancer Drugs in the Spheroid of Human Lung Adenocarcinoma A549 Cells. Int J Mol Sci. 2021;22: pubmed publisher |
| Cray P, Sheahan B, Cortes J, Dekaney C. Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers. Sci Rep. 2020;10:21486 pubmed publisher |
| Hachimi M, Grabowski C, Campanario S, Herranz G, Baonza G, Serrador J, et al. Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis. Curr Biol. 2020;: pubmed publisher |
| Uc P, Miranda J, Raya Sandino A, Alarcón L, Roldán M, Ocadiz Delgado R, et al. E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions. Int J Oncol. 2020;57:905-924 pubmed publisher |
| Wang H, Jiang Y, Li H, Wang J, Li C, Zhang D. Carbachol protects the intestinal barrier in severe acute pancreatitis by regulating Cdc42/F-actin cytoskeleton. Exp Ther Med. 2020;20:2828-2837 pubmed publisher |
| Casselbrant A, F ndriks L, Wallenius V. Glycocholic acid and butyrate synergistically increase vitamin D-induced calcium uptake in Caco-2 intestinal epithelial cell monolayers. Bone Rep. 2020;13:100294 pubmed publisher |
| Raju P, Shashikanth N, Tsai P, Pongkorpsakol P, Chánez Paredes S, Steinhagen P, et al. Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice. J Clin Invest. 2020;130:5197-5208 pubmed publisher |
| Lee J, Kim N, Choi Y, Park J, Ashktorab H, Smoot D, et al. Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex. J Neurogastroenterol Motil. 2020;26:248-258 pubmed publisher |
| Kjærgaard S, Damm M, Chang J, Riis L, Rasmussen H, Hytting Andreasen R, et al. Altered Structural Expression and Enzymatic Activity Parameters in Quiescent Ulcerative Colitis: Are These Potential Normalization Criteria?. Int J Mol Sci. 2020;21: pubmed publisher |
| Flores Maldonado C, Albino S xe1 nchez M, Rodr xed guez Callejas J, Estrada Mondragón A, Le xf3 n Galicia I, Maqueda Alfaro R, et al. A Low Cost Antibody Signal Enhancer Improves Immunolabeling in Cell Culture, Primate Brain and Human Cancer Biopsy. Neuroscience. 2020;439:275-286 pubmed publisher |
| Gamero Estévez E, Andonian S, Jean Claude B, Gupta I, Ryan A. Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells. Int J Mol Sci. 2019;20: pubmed publisher |
| Miranda J, Martín Tapia D, Valdespino Vazquez Y, Alarcón L, Espejel Nuñez A, Guzmán Huerta M, et al. Syncytiotrophoblast of Placentae from Women with Zika Virus Infection Has Altered Tight Junction Protein Expression and Increased Paracellular Permeability. Cells. 2019;8: pubmed publisher |
| Luo Y, Xu J, Zhang C, Jiang C, Ma Y, He H, et al. Toll-like receptor 5-mediated IL-17C expression in intestinal epithelial cells enhances epithelial host defense against F4+ ETEC infection. Vet Res. 2019;50:48 pubmed publisher |
| Kumar R, Gong H, Liu L, Ramos Solis N, Seye C, Derbigny W. TLR3 deficiency exacerbates the loss of epithelial barrier function during genital tract Chlamydia muridarum infection. PLoS ONE. 2019;14:e0207422 pubmed publisher |
| Schlegel C, Weis V, Knowles B, Lapierre L, Martin M, Dickman P, et al. Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease. Dig Dis Sci. 2018;63:356-365 pubmed publisher |
| Buzza M, Johnson T, Conway G, Martin E, Mukhopadhyay S, Shea Donohue T, et al. Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis. J Biol Chem. 2017;292:10801-10812 pubmed publisher |
| Nighot P, Leung L, Ma T. Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin. Exp Cell Res. 2017;352:113-122 pubmed publisher |
| Hichino A, Okamoto M, Taga S, Akizuki R, Endo S, Matsunaga T, et al. Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. J Biol Chem. 2017;292:2411-2421 pubmed publisher |
| Randall K, Henderson N, Reens J, Eckersley S, Nyström A, South M, et al. Claudin-2 Expression Levels in Ulcerative Colitis: Development and Validation of an In-Situ Hybridisation Assay for Therapeutic Studies. PLoS ONE. 2016;11:e0162076 pubmed publisher |
| Maggiorani D, Dissard R, Belloy M, Saulnier Blache J, Casemayou A, Ducassé L, et al. Shear Stress-Induced Alteration of Epithelial Organization in Human Renal Tubular Cells. PLoS ONE. 2015;10:e0131416 pubmed publisher |
| Amoozadeh Y, Dan Q, Xiao J, Waheed F, Szászi K. Tumor necrosis factor-α induces a biphasic change in claudin-2 expression in tubular epithelial cells: role in barrier functions. Am J Physiol Cell Physiol. 2015;309:C38-50 pubmed publisher |
| Staat C, Coisne C, Dabrowski S, Stamatovic S, Andjelkovic A, Wolburg H, et al. Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers. Biomaterials. 2015;54:9-20 pubmed publisher |
| Casselbrant A, Elias E, Fändriks L, Wallenius V. Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2015;11:45-53 pubmed publisher |
| García Hernández V, Flores Maldonado C, Rincon Heredia R, Verdejo Torres O, Bonilla Delgado J, Meneses Morales I, et al. EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells. J Cell Physiol. 2015;230:105-15 pubmed publisher |
| Retana C, Sanchez E, Perez Lopez A, Cruz A, Lagunas J, Cruz C, et al. Alterations of intercellular junctions in peritoneal mesothelial cells from patients undergoing dialysis: effect of retinoic Acid. Perit Dial Int. 2015;35:275-87 pubmed publisher |
