SMAD2 Polyclonal Antibody | Invitrogen 51-1300 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SMAD2 Polyclonal Antibody

catalog :

51-1300

quantity :

100 ug

price :

US 520.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 16

Reference
Patricelli C, Lehmann P, Oxford J, Pu X. Doxorubicin-induced modulation of TGF-β signaling cascade in mouse fibroblasts: insights into cardiotoxicity mechanisms. Sci Rep. 2023;13:18944 pubmed publisher
Wu S, Xia Y, Yang C, Li M. Protective effects of aloin on asthmatic mice by activating Nrf2/HO-1 pathway and inhibiting TGF-β/Smad2/3 pathway. Allergol Immunopathol (Madr). 2023;51:10-18 pubmed publisher
W xf3 jcik Pszczo x142 a K, Ch x142 o x144 Rzepa G, Jankowska A, Ferreira B, Koczurkiewicz Adamczyk P, P x119 kala E, et al. Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation. Pharmaceuticals (Basel). 2022;15: pubmed publisher
Huang S, Huang P, Wu H, Wang S, Liu G. LINC02381 aggravates breast cancer through the miR-1271-5p/FN1 axis to activate PI3K/AKT pathway. Mol Carcinog. 2022;61:346-358 pubmed publisher
Kim I, Lee M, Park M, Seong E, Lee D, Lee S, et al. Deletion of Akt1 Promotes Kidney Fibrosis in a Murine Model of Unilateral Ureteral Obstruction. Biomed Res Int. 2020;2020:6143542 pubmed publisher
Tosi G, Regoli M, Altera A, Galvagni F, Arcuri C, Bacci T, et al. Heat Shock Protein 90 Involvement in the Development of Idiopathic Epiretinal Membranes. Invest Ophthalmol Vis Sci. 2020;61:34 pubmed publisher
Watanabe H, Goto S, Kato R, Komiyama S, Nagaoka Y, Kazama T, et al. The neovascularization effect of dedifferentiated fat cells. Sci Rep. 2020;10:9211 pubmed publisher
Wójcik Pszczoła K, Chłoń Rzepa G, Jankowska A, Ślusarczyk M, Ferdek P, Kusiak A, et al. A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling. Int J Mol Sci. 2020;21: pubmed publisher
Zhang S, Wang Q, Yang Q, Gu H, Yin Y, Li Y, et al. NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis. BMC Med. 2019;17:204 pubmed publisher
Devocelle A, Lecru L, Francois H, Desterke C, Gallerne C, Eid P, et al. Inhibition of TGF-β1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-β1-Induced EMT in Renal Fibrosis. Int J Cell Biol. 2019;2019:9151394 pubmed publisher
Albers R, Selesniemi K, Natale D, Brown T. TGF-β induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation. Int J Stem Cells. 2018;11:111-120 pubmed publisher
DiMario J. KLF10 Gene Expression Modulates Fibrosis in Dystrophic Skeletal Muscle. Am J Pathol. 2018;188:1263-1275 pubmed publisher
Howe G, Kazda K, Addison C. MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2. PLoS ONE. 2017;12:e0185619 pubmed publisher
Chuvin N, Vincent D, Pommier R, Alcaraz L, Gout J, Caligaris C, et al. Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis. Cell Mol Gastroenterol Hepatol. 2017;4:263-282 pubmed publisher
Al Hendy A, Laknaur A, Diamond M, Ismail N, Boyer T, Halder S. Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/Î²-Catenin Signaling Pathway. Endocrinology. 2017;158:592-603 pubmed publisher
Dubrulle J, Jordan B, Akhmetova L, Farrell J, Kim S, Solnica Krezel L, et al. Response to Nodal morphogen gradient is determined by the kinetics of target gene induction. elife. 2015;4: pubmed publisher

product information

Product Type :

Antibody

Product Name :

SMAD2 Polyclonal Antibody

Catalog # :

51-1300

Quantity :

100 ug

Price :

US 520.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ChIP Assay: 1-3 ug x 10^6 cells, ELISA: 0.1-1.0 ug/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1-3 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

SMAD2 (MADH2, MAD2) regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 interacts with the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin-binding region of the MH1 domain by extracellular signal regulated kinase 1 (ERK1) enhances SMAD2 transcriptional activity, which is negatively regulated by calmodulin. In response to the TGF-beta signal, SMAD2 is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. SMAD2 can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the SMAD2 protein have been observed.

Immunogen :

A 27 amino acid synthetic peptide derived from the MH1 domain of human Smad2. This peptide shares 24/27 residues with the mouse Smad2 protein and 26/27 residues with the Xenopus Smad2 protein.

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1-3 ug x 10^6 cells, ELISA: 0.1-1.0 ug/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1-3 ug/mL

Aliases :

7120426M23Rik; EGK_09664; hMAD-2; hSMAD2; JV18; JV18-1; MAD; MAD homolog 2; Mad protein homolog; Madh2; Madr2; Mad-related protein 2; MGC22139; MGC34440; mMad2; mother against DPP homolog 2; mothers against decapentaplegic homolog 2; Mothers against decapentaplegic-like protein 2; mothers against DPP homolog 2; pSMAD2; Sma- and Mad-related protein 2; SMAD; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; Smad2; Smad-2; Smad2Deltaexon3