RELM alpha Polyclonal Antibody, PeproTech | Invitrogen 500-P214-50UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RELM alpha Polyclonal Antibody, PeproTech

catalog :

500-P214-50UG

quantity :

50 ug

price :

US 238.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, ELISA

citations: 11

Reference
Dániel B, Belk J, Meier S, Chen A, Sandor K, Czimmerer Z, et al. Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state. Mol Cell. 2023;83:121-138.e7 pubmed publisher
Dichtl S, Sanin D, Koss C, Willenborg S, Petzold A, Tanzer M, et al. Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF. Life Sci Alliance. 2022;5: pubmed publisher
Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Gu xe9 nantin A, et al. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation. Nat Metab. 2021;3:1150-1162 pubmed publisher
Piattini F, Matsushita M, Muri J, Bretscher P, Feng X, Freigang S, et al. Differential sensitivity of inflammatory macrophages and alternatively activated macrophages to ferroptosis. Eur J Immunol. 2021;51:2417-2429 pubmed publisher
Ajendra J, Chenery A, Parkinson J, Chan B, Pearson S, Colombo S, et al. IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection. Mucosal Immunol. 2020;13:958-968 pubmed publisher
Panova V, Gogoi M, Rodriguez Rodriguez N, Sivasubramaniam M, Jolin H, Heycock M, et al. Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11. Mucosal Immunol. 2021;14:26-37 pubmed publisher
Wang Y, Zaitsev K, Lu Q, Li S, Schaiff W, Kim K, et al. Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. Nat Microbiol. 2020;5:272-281 pubmed publisher
Jarjour N, Bradstreet T, Schwarzkopf E, Cook M, Lai C, Huang S, et al. BHLHE40 Promotes TH2 Cell-Mediated Antihelminth Immunity and Reveals Cooperative CSF2RB Family Cytokines. J Immunol. 2020;204:923-932 pubmed publisher
Chenery A, Alhallaf R, Agha Z, Ajendra J, Parkinson J, Cooper M, et al. Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung. J Immunol. 2019;203:2724-2734 pubmed publisher
Bancroft A, Levy C, Jowitt T, Hayes K, Thompson S, McKenzie E, et al. The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function. Nat Commun. 2019;10:2344 pubmed publisher
Minutti C, Modak R, MacDonald F, Li F, Smyth D, Dorward D, et al. A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation. Immunity. 2019;50:645-654.e6 pubmed publisher

product information

Product Type :

Antibody

Product Name :

RELM alpha Polyclonal Antibody, PeproTech

Catalog # :

500-P214-50UG

Quantity :

50 ug

Price :

US 238.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Mouse

Applications :

ELISA: 0.5-2.0 ug/mL, Western Blot: 0.1-0.2 ug/mL

Species :

Mouse

Storage :

-20 C

Description :

RELM alpha, also known as Resistin-like alpha or FIZZ1, is a small cytokine (88 aminoacids, MW 9.4 kDa) produced mostly by macrophages. Its highest constitutive expression has been observed in small peritoneal macrophages, alveolar macrophages and adipose tissue macrophages. It is strongly induced by IL-4 and IL-13. Together with Arginase 1 and Ym-1, RELM alpha is considered one of the hallmarks of the M2 polarization of mouse macrophages, however, macrophages polarized with IL-10 (M2c) express neither RELM alpha nor Arginase 1. Also, the expression patterns of RELM alpha and Arginase 1 in untreated tissue macrophages significantly differ. Elevated levels of RELM alpha may indicate parasitic infection. Humans do not have RELM alpha gene but human Resistin resembles mouse RELM alpha in respect to sequence, tissue distribution and function. Other members of RELM family in mouse: RELM beta, RELM gamma and Resistin display different tissue distribution and functional properties. RELM alpha plays an important role in parasite infection, mucosal inflammation and allergy.

Immunogen :

E.coli-derived Recombinant Murine RELMalpha

Format :

Lyophilized

Applications w/Dilutions :

ELISA: 0.5-2.0 ug/mL, Western Blot: 0.1-0.2 ug/mL

Aliases :

1810019L16Rik; cysteine-rich secreted protein A12-gamma; Cysteine-rich secreted protein FIZZ1; Fizz1; Fizz-1; FIZZ2; found in inflammatory zone 1; Himf; HXCP2; Hypoxia-induced mitogenic factor; parasite-induced macrophage novel gene 1 protein; Pmng1; RELMa; RELMalpha; RELM-alpha; RELMb; RELMbeta; RELM-beta; resistin like alpha; resistin-like alpha; Retnla; Xcp2