MCP-1 Monoclonal Antibody, PeproTech | Invitrogen 500-M71-500UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MCP-1 Monoclonal Antibody, PeproTech

catalog :

500-M71-500UG

quantity :

500 ug

price :

US 190.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA

citations: 11

Reference
Erlichman N, Baram T, Meshel T, Morein D, Da adoosh B, Ben Baruch A. Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes. Cancers (Basel). 2022;14: pubmed publisher
Liubomirski Y, Lerrer S, Meshel T, Rubinstein Achiasaf L, Morein D, Wiemann S, et al. Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer. Front Immunol. 2019;10:757 pubmed publisher
Lerrer S, Liubomirski Y, Bott A, Abnaof K, Oren N, Yousaf A, et al. Co-Inflammatory Roles of TGF?1 in the Presence of TNF? Drive a Pro-inflammatory Fate in Mesenchymal Stem Cells. Front Immunol. 2017;8:479 pubmed publisher
Barzilai S, Blecher Gonen R, Barnett Itzhaki Z, Zauberman A, Lebel Haziv Y, Amit I, et al. M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration. J Leukoc Biol. 2016;99:1045-55 pubmed publisher
Katanov C, Lerrer S, Liubomirski Y, Leider Trejo L, Meshel T, Bar J, et al. Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-? and the NF-?B pathway. Stem Cell Res Ther. 2015;6:87 pubmed publisher
Lebel Haziv Y, Meshel T, Soria G, Yeheskel A, Mamon E, Ben Baruch A. Breast cancer: coordinated regulation of CCL2 secretion by intracellular glycosaminoglycans and chemokine motifs. Neoplasia. 2014;16:723-40 pubmed publisher
Leibovich Rivkin T, Liubomirski Y, Meshel T, Abashidze A, Brisker D, Solomon H, et al. The inflammatory cytokine TNF? cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells. BMC Cancer. 2014;14:158 pubmed publisher
Leibovich Rivkin T, Liubomirski Y, Bernstein B, Meshel T, Ben Baruch A. Inflammatory factors of the tumor microenvironment induce plasticity in nontransformed breast epithelial cells: EMT, invasion, and collapse of normally organized breast textures. Neoplasia. 2013;15:1330-46 pubmed
Weitzenfeld P, Meron N, Leibovich Rivkin T, Meshel T, Ben Baruch A. Progression of luminal breast tumors is promoted by ménage à trois between the inflammatory cytokine TNF? and the hormonal and growth-supporting arms of the tumor microenvironment. Mediators Inflamm. 2013;2013:720536 pubmed publisher
Leibovich Rivkin T, Buganim Y, Solomon H, Meshel T, Rotter V, Ben Baruch A. Tumor-promoting circuits that regulate a cancer-related chemokine cluster: dominance of inflammatory mediators over oncogenic alterations. Cancers (Basel). 2012;4:55-76 pubmed publisher
Fantuzzi L, Spadaro F, Vallanti G, Canini I, Ramoni C, Vicenzi E, et al. Endogenous CCL2 (monocyte chemotactic protein-1) modulates human immunodeficiency virus type-1 replication and affects cytoskeleton organization in human monocyte-derived macrophages. Blood. 2003;102:2334-7 pubmed

product information

Product Type :

Antibody

Product Name :

MCP-1 Monoclonal Antibody, PeproTech

Catalog # :

500-M71-500UG

Quantity :

500 ug

Price :

US 190.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 1.0-2.0 ug/mL, Western Blot: 0.20-0.40 ug/mL

Species :

Human

Storage :

-20 C

Description :

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Immunogen :

E.coli-derived Recombinant Human MCP-1 (CCL2)

Format :

Lyophilized

Applications w/Dilutions :

ELISA: 1.0-2.0 ug/mL, Western Blot: 0.20-0.40 ug/mL

Aliases :

Acidic seminal fluid protein; AI323594; C-C motif chemokine 2; C-C motif chemokine ligand 2; Ccl2; chemokine (C-C motif) ligand 2; GDCF-2; HC11; H-MCP-1; HSMCR30; immediate-early serum-responsive JE protein; immediate-early serum-responsive protein JE; Je; MCAF; Mcp1; MCP-1; MCP1A; MCP-1A; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; monocyte chemotactic protein 1A; Monocyte secretory protein JE; monocyte-chemoattractant protein-1 precursor; platelet-derived growth factor-inducible protein JE; RP23-350G1.3; SCYA2; Sigje; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible gene JE; small-inducible cytokine A2; SMC-CF