This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
GFAP Monoclonal Antibody (GA5), eFluor 660, eBioscience
catalog :
50-9892-80
quantity :
25 ug
price :
US 187.00
clonality :
monoclonal
host :
mouse
conjugate :
efluor 660
clone name :
GA5

The same clone is also sold as:
reactivity :
human, mouse, rat, chicken, pigs , domestic rabbit
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 33
Reference
Mazzitelli M, Ponomareva O, Presto P, John J, Neugebauer V. Impaired amygdala astrocytic signaling worsens neuropathic pain-associated neuronal functions and behaviors. Front Pharmacol. 2024;15:1368634 pubmed publisher
Yu K, Basu S, Baquer G, Ahn R, Gantchev J, Jindal S, et al. Investigative needle core biopsies for multi-omics in Glioblastoma. medRxiv. 2023;: pubmed publisher
Novakovic M, Korshunov K, Grant R, Martin M, Valencia H, Budinger G, et al. Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels. Nat Commun. 2023;14:5500 pubmed publisher
Shin J, Cho B, Park J, Kang E, Kim Y, Jang S. Diospyros lotus leaf extract and its main component myricitrin regulate pruritus through the inhibition of astrocyte activation. Exp Ther Med. 2023;26:323 pubmed publisher
Cheng W, Cheung H, Kang A, Fan J, Cooper J, Anwer M, et al. Altered Tau Kinase Activity in rTg4510 Mice after a Single Interfaced CHIMERA Traumatic Brain Injury. Int J Mol Sci. 2023;24: pubmed publisher
Obara K, Shirai K, Hamada Y, Arakawa N, Hasegawa A, Takaoka N, et al. Direct implantation of hair-follicle-associated pluripotent (HAP) stem cells repairs intracerebral hemorrhage and reduces neuroinflammation in mouse model. PLoS ONE. 2023;18:e0280304 pubmed publisher
Mok K, Yeung S, Cheng G, Ma I, Lee R, Herrup K, et al. Apolipoprotein E ε4 disrupts oligodendrocyte differentiation by interfering with astrocyte-derived lipid transport. J Neurochem. 2023;165:55-75 pubmed publisher
Xuan F, Yan L, Li Y, Fan F, Deng H, Gou M, et al. Glial receptor PLXNB2 regulates schizophrenia-related stress perception via the amygdala. Front Immunol. 2022;13:1005067 pubmed publisher
Zhang Q, Abdo R, Iosef C, Kaneko T, Cecchini M, Han V, et al. The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis. Nat Commun. 2022;13:5983 pubmed publisher
Battistella E, Schniete J, Wesencraft K, Quintana J, McConnell G. Light-sheet mesoscopy with the Mesolens provides fast sub-cellular resolution imaging throughout large tissue volumes. iScience. 2022;25:104797 pubmed publisher
Zhang J, Hou P, Shao S, Manaenko A, Xiao Z, Chen Y, et al. microRNA-455-5p alleviates neuroinflammation in cerebral ischemia/reperfusion injury. Neural Regen Res. 2022;17:1769-1775 pubmed publisher
Marini C, Cossu V, Kumar M, Milanese M, Cortese K, Bruno S, et al. The Role of Endoplasmic Reticulum in the Differential Endurance against Redox Stress in Cortical and Spinal Astrocytes from the Newborn SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis. Antioxidants (Basel). 2021;10: pubmed publisher
Gratuze M, Chen Y, Parhizkar S, Jain N, Strickland M, Serrano J, et al. Activated microglia mitigate Aβ-associated tau seeding and spreading. J Exp Med. 2021;218: pubmed publisher
Wu J, Chen N, Liu Y, Godlewski G, Kaplan H, Shrader S, et al. Studies of involvement of G-protein coupled receptor-3 in cannabidiol effects on inflammatory responses of mouse primary astrocytes and microglia. PLoS ONE. 2021;16:e0251677 pubmed publisher
Gebril H, Wahba A, Zhou X, Lai T, Alharfoush E, Dicicco Bloom E, et al. Developmental Role of Adenosine Kinase in the Cerebellum. Eneuro. 2021;8: pubmed publisher
Lee E, Winston Gray C, Barlow J, Rissman R, Jeste D. Plasma Levels of Neuron- and Astrocyte-Derived Exosomal Amyloid Beta1-42, Amyloid Beta1-40, and Phosphorylated Tau Levels in Schizophrenia Patients and Non-psychiatric Comparison Subjects: Relationships With Cognitive Functioning and Psychopathology. Front Psychiatry. 2020;11:532624 pubmed publisher
. CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS. Neurol Neuroimmunol Neuroinflamm. 2021;8: pubmed publisher
Borggrewe M, Grit C, Vainchtein I, Brouwer N, Wesseling E, Laman J, et al. Regionally diverse astrocyte subtypes and their heterogeneous response to EAE. Glia. 2021;69:1140-1154 pubmed publisher
Martins C, Neves L, de Oliveira M, Bagatini P, Barboza R, Mestriner R, et al. Neuroprotective effect of ACTH on collagenase-induced peri-intraventricular hemorrhage in newborn male rats. Sci Rep. 2020;10:17734 pubmed publisher
Upadhyay M, Milliner C, Bell B, Bonilha V. Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1. Redox Biol. 2020;:101623 pubmed publisher
Liu J, Zhu Y, Guo Y, Lin L, Wang Z, Gu F, et al. Inhibition of GSK3β and RIP1K Attenuates Glial Scar Formation Induced by Ischemic Stroke via Reduction of Inflammatory Cytokine Production. Front Pharmacol. 2020;11:812 pubmed publisher
Oh J, Hwang T, Jang J, Park J, Ryu Y, Lee H, et al. Muscovite nanoparticles mitigate neuropathic pain by modulating the inflammatory response and neuroglial activation in the spinal cord. Neural Regen Res. 2020;15:2162-2168 pubmed publisher
Rayaprolu S, Gao T, Xiao H, Ramesha S, Weinstock L, Shah J, et al. Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease. Mol Neurodegener. 2020;15:28 pubmed publisher
Kosuge Y, Kaneko E, Nango H, Miyagishi H, Ishige K, Ito Y. Bidens pilosa Extract Administered after Symptom Onset Attenuates Glial Activation, Improves Motor Performance, and Prolongs Survival in a Mouse Model of Amyotrophic Lateral Sclerosis. Oxid Med Cell Longev. 2020;2020:1020673 pubmed publisher
McWilliams I, Kielczewski J, Ireland D, Sykes J, Lewkowicz A, Konduru K, et al. Pseudovirus rVSVΔG-ZEBOV-GP Infects Neurons in Retina and CNS, Causing Apoptosis and Neurodegeneration in Neonatal Mice. Cell Rep. 2019;26:1718-1726.e4 pubmed publisher
Yan J, Zhao Q, Gabrusiewicz K, Kong L, Xia X, Wang J, et al. FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nat Commun. 2019;10:448 pubmed publisher
Cheng W, Martens K, Bashir A, Cheung H, Stukas S, Gibbs E, et al. CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice. Alzheimers Res Ther. 2019;11:6 pubmed publisher
Nicholatos J, Francisco A, Bender C, Yeh T, Lugay F, Salazar J, et al. Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6. Acta Neuropathol Commun. 2018;6:120 pubmed publisher
Nguyen L, Fregeac J, Bole Feysot C, Cagnard N, Iyer A, Anink J, et al. Role of miR-146a in neural stem cell differentiation and neural lineage determination: relevance for neurodevelopmental disorders. Mol Autism. 2018;9:38 pubmed publisher
Wu L, Ye Z, Zhou C, Wang C, Xie G, Zhang X, et al. Roles of Pannexin-1 Channels in Inflammatory Response through the TLRs/NF-Kappa B Signaling Pathway Following Experimental Subarachnoid Hemorrhage in Rats. Front Mol Neurosci. 2017;10:175 pubmed publisher
Jin W, Shi S, Li Z, Li M, Wood K, Gonzales R, et al. Depletion of microglia exacerbates postischemic inflammation and brain injury. J Cereb Blood Flow Metab. 2017;37:2224-2236 pubmed publisher
Fang H, Chen J, Lin S, Wang P, Wang Y, Xiong X, et al. CD36-mediated hematoma absorption following intracerebral hemorrhage: negative regulation by TLR4 signaling. J Immunol. 2014;192:5984-92 pubmed publisher
Vazquez Cintron E, Vakulenko M, Band P, Stanker L, Johnson E, Ichtchenko K. Atoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasm. PLoS ONE. 2014;9:e85517 pubmed publisher
product information
Product Type :
Antibody
Product Name :
GFAP Monoclonal Antibody (GA5), eFluor 660, eBioscience
Catalog # :
50-9892-80
Quantity :
25 ug
Price :
US 187.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Chicken, Human, Mouse, Porcine, Rabbit, Rat
Applications :
Flow Cytometry: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): 10 ug/mL, Immunohistochemistry (Paraffin): 10 ug/mL
Species :
Chicken, Human, Mouse, Porcine, Rabbit, Rat
Clone :
GA5
Isotype :
IgG1
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): 10 ug/mL, Immunohistochemistry (Paraffin): 10 ug/mL
Aliases :
6330404F12Rik; 65 kDa glutamic acid decarboxylase; AI836096; ALXDRD; Astrocyte or Intermediate Filament Protein; cb345; class III intermediate filament protein; etID36982.3; FLJ45472; GAD(65); Gad2; Gad-2; GAD65; GAD-65; GFAP; GFAP epsilon; gfap protein; gfapl; glial fibrillary acidic protein; Glial Fibrillary Acidic Protein (GFAP); glial fibrillary acidic protein alpha; glutamate decarboxylase 2; Glutamate decarboxylase 65 kDa isoform; glutamic acid decarboxylase 2; I79_011607; intermediate filament; intermediate filament protein; intermediate filament protein; GFAP; Unknown (protein for MGC:139638); wu:fb34h11; wu:fk42c12; xx:af506734; zgc:110485; zGFAP; intermediate filament protein; zrf-1 antigen
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA