This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
SAP (SLAM-Associated Protein) Monoclonal Antibody (XLP-1D12), eFluor 660, eBioscience
catalog :
50-9787-42
quantity :
100 Tests
price :
US 480.00
clonality :
monoclonal
host :
rat
conjugate :
efluor 660
clone name :
XLP-1D12
reactivity :
human
application :
flow cytometry
citations: 9
Reference
Gartshteyn Y, Geraldino Pardilla L, Khalili L, Bukhari S, Lerrer S, Winchester R, et al. SAP-expressing T peripheral helper cells identify systemic lupus erythematosus patients with lupus nephritis. Front Immunol. 2024;15:1327437 pubmed publisher
Korniotis S, Saichi M, Trichot C, Hoffmann C, Amblard E, Viguier A, et al. GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization in a CD40-dependent manner. J Cell Sci. 2022;135: pubmed publisher
Zhong M, Veillette A. Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity. Mol Cell Biol. 2013;33:1223-32 pubmed publisher
Bediako Y, Bian Y, Zhang H, Cho H, Stein P, Wang C. SAP is required for the development of innate phenotype in H2-M3--restricted Cd8(+) T cells. J Immunol. 2012;189:4787-96 pubmed publisher
Proust R, Bertoglio J, Gesbert F. The adaptor protein SAP directly associates with CD3? chain and regulates T cell receptor signaling. PLoS ONE. 2012;7:e43200 pubmed publisher
Detre C, Keszei M, Garrido Mesa N, Kis Toth K, Castro W, Agyemang A, et al. SAP expression in invariant NKT cells is required for cognate help to support B-cell responses. Blood. 2012;120:122-9 pubmed publisher
Kroenke M, Eto D, Locci M, Cho M, Davidson T, Haddad E, et al. Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol. 2012;188:3734-44 pubmed publisher
Marsh R, Bleesing J, Filipovich A. Using flow cytometry to screen patients for X-linked lymphoproliferative disease due to SAP deficiency and XIAP deficiency. J Immunol Methods. 2010;362:1-9 pubmed publisher
Kamperschroer C, Roberts D, Zhang Y, Weng N, Swain S. SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation. J Immunol. 2008;181:3994-4003 pubmed
product information
Product Type :
Antibody
Product Name :
SAP (SLAM-Associated Protein) Monoclonal Antibody (XLP-1D12), eFluor 660, eBioscience
Catalog # :
50-9787-42
Quantity :
100 Tests
Price :
US 480.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL (0.03 ug)/test
Species :
Human
Clone :
XLP-1D12
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL (0.03 ug)/test
Aliases :
DSHP; Duncan disease homolog; Duncan disease SH2-protein; Duncan's disease; EBVS; FLJ18687; FLJ92177; Gm686; HGNC:10820; IMD5; LYP; MTCP1; RGD1562408; RP5-1052M9.3; SAP; SAP/SH2D1A; SH2 domain containing 1A; SH2 domain protein 1A; SH2 domain-containing protein 1A; SH2D1A; signaling lymphocyte activation molecule-associated protein; signaling lymphocytic activation molecule-associated protein; SLAM associated protein/SH2 domain protein 1A; SLAM-associated protein; SLAM-associated protein isoform SAP-2; T cell signal transduction molecule SAP; T-cell signal transduction molecule SAP; Xlp; XLPD; XLPD1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA