Phospho-4EBP1 (Thr36, Thr45) Monoclonal Antibody (V3NTY24), eFluor 660, eBioscience | Invitrogen 50-9107-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-4EBP1 (Thr36, Thr45) Monoclonal Antibody (V3NTY24), eFluor 660, eBioscience

catalog :

50-9107-42

quantity :

100 Tests

price :

US 462.00

clonality :

monoclonal

host :

mouse

conjugate :

efluor 660

clone name :

V3NTY24

reactivity :

human, mouse

application :

flow cytometry

citations: 6

Reference
Borsa M, Obba S, Richter F, Zhang H, Riffelmacher T, Carrelha J, et al. Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism. Autophagy. 2024;20:45-57 pubmed publisher
Gkirtzimanaki K, Kabrani E, Nikoleri D, Polyzos A, Blanas A, Sidiropoulos P, et al. IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion. Cell Rep. 2018;25:921-933.e5 pubmed publisher
Bar D, Charar C, Dorfman J, Yadid T, Tafforeau L, Lafontaine D, et al. Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor. Proc Natl Acad Sci U S A. 2016;113:E4620-9 pubmed publisher
Gingras A, Gygi S, Raught B, Polakiewicz R, Abraham R, Hoekstra M, et al. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 1999;13:1422-37 pubmed
Gingras A, Kennedy S, O Leary M, Sonenberg N, Hay N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 1998;12:502-13 pubmed
Brunn G, Hudson C, Sekulic A, Williams J, Hosoi H, Houghton P, et al. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science. 1997;277:99-101 pubmed

product information

Product Type :

Antibody

Product Name :

Phospho-4EBP1 (Thr36, Thr45) Monoclonal Antibody (V3NTY24), eFluor 660, eBioscience

Catalog # :

50-9107-42

Quantity :

100 Tests

Price :

US 462.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 5 uL (0.06 ug)/test

Species :

Human, Mouse

Clone :

V3NTY24

Isotype :

IgG2b, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.06 ug)/test

Aliases :

4EBP1; 4E-BP1; AA959816; BP-1; eIF4E-binding protein 1; EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; MGC431; MGC4316; P/OKCL.6; PHAS-1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1