This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-21 Monoclonal Antibody (mhalx21), eFluor 660, eBioscience
catalog :
50-7213-82
quantity :
100 ug
price :
US 383.00
clonality :
monoclonal
host :
rat
conjugate :
efluor 660
clone name :
mhalx21
reactivity :
mouse
application :
flow cytometry
citations: 8
Reference
Luu M, Binder K, Hartmann S, Kespohl M, Bazant J, Romero R, et al. Transcription factor c-Rel mediates communication between commensal bacteria and mucosal lymphocytes. J Leukoc Biol. 2022;111:1001-1007 pubmed publisher
Lu M, Zhang Y, Dravid P, Li A, Zeng C, Kc M, et al. A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters. J Virol. 2021;95:e0059221 pubmed publisher
Kawata K, Suzuki T, Ozawa K, Sekiguchi M. Features of T-cell subset composition in a D-galactose-induced senescence mouse model. Exp Anim. 2021;70:284-292 pubmed publisher
Lewis P, Poteet E, Liu D, Chen C, LaBranche C, Stanfield Oakley S, et al. CTLA-4 Blockade, during HIV Virus-Like Particles Immunization, Alters HIV-Specific B-Cell Responses. Vaccines (Basel). 2020;8: pubmed publisher
Pot C, Jin H, Awasthi A, Liu S, Lai C, Madan R, et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol. 2009;183:797-801 pubmed publisher
Konforte D, Paige C. Interleukin-21 regulates expression of the immediate-early lytic cycle genes and proteins in Epstein-Barr Virus infected B cells. Virus Res. 2009;144:339-43 pubmed publisher
Elsaesser H, Sauer K, Brooks D. IL-21 is required to control chronic viral infection. Science. 2009;324:1569-72 pubmed publisher
Bauquet A, Jin H, Paterson A, Mitsdoerffer M, Ho I, Sharpe A, et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol. 2009;10:167-75 pubmed publisher
product information
Product Type :
Antibody
Product Name :
IL-21 Monoclonal Antibody (mhalx21), eFluor 660, eBioscience
Catalog # :
50-7213-82
Quantity :
100 ug
Price :
US 383.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Mouse
Clone :
mhalx21
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA