Themis Monoclonal Antibody (1TMYS), eFluor 660, eBioscience | Invitrogen 50-5918-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Themis Monoclonal Antibody (1TMYS), eFluor 660, eBioscience

catalog :

50-5918-82

quantity :

100 ug

price :

US 470.00

clonality :

monoclonal

host :

rat

conjugate :

efluor 660

clone name :

1TMYS

reactivity :

mouse

application :

flow cytometry

citations: 6

Reference
Paster W, Brockmeyer C, Fu G, Simister P, de Wet B, Martinez RiaÃ±o A, et al. GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. J Immunol. 2013;190:3749-56 pubmed publisher
Brockmeyer C, Paster W, Pepper D, Tan C, Trudgian D, McGowan S, et al. T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem. 2011;286:7535-47 pubmed publisher
Patrick M, Oda H, Hayakawa K, Sato Y, Eshima K, Kirikae T, et al. Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Proc Natl Acad Sci U S A. 2009;106:16345-50 pubmed publisher
Fu G, Vallee S, Rybakin V, McGuire M, Ampudia J, Brockmeyer C, et al. Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol. 2009;10:848-56 pubmed publisher
Lesourne R, Uehara S, Lee J, Song K, Li L, Pinkhasov J, et al. Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol. 2009;10:840-7 pubmed publisher
Johnson A, Aravind L, Shulzhenko N, Morgun A, Choi S, Crockford T, et al. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol. 2009;10:831-9 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Themis Monoclonal Antibody (1TMYS), eFluor 660, eBioscience

Catalog # :

50-5918-82

Quantity :

100 ug

Price :

US 470.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 ug/test

Species :

Mouse

Clone :

1TMYS

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Themis is a cytoplasmic protein that is essential for positive selection and the development of single-positive thymocytes. Highest levels of expression are found in CD4+CD8+ double-positive thymocytes, with lower expression found in mature T cells. In addition to Grb1, Themis has been found to associate with PLC gamma 1 and LAT and is quickly phosphorylated by SLP-76 following TCR signaling. There are 5 isoforms of mouse Themis that are produced as a result of alternative splicing.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 ug/test

Aliases :

bA325O24.3; bA325O24.4; C6orf190; C6orf207; E430004N04Rik; FLJ40584; Gasp; GRB2-associated protein; Grb2-associating protein; MGC163388; Protein THEMIS; Protein thylex; RGD1560849; signaling phosphoprotein specific for T cells; SPOT; THEMIS; thylex; thymocyte expressed molecule involved in selection; thymocyte selection associated; thymocyte selection pathway associated; thymocyte-expressed molecule involved in selection; Tsepa