CD169 (Siglec-1) Monoclonal Antibody (SER-4), eFluor™ 660, eBioscience | Invitrogen 50-5755-80 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD169 (Siglec-1) Monoclonal Antibody (SER-4), eFluor™ 660, eBioscience

catalog :

50-5755-80

quantity :

25 µg

price :

US 309.00

clonality :

monoclonal

host :

rat

conjugate :

efluor 660

clone name :

SER-4

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 3a	McElrath C, Espinosa V, Lin J, Peng J, Sridhar R, Dutta O, et al. Critical role of interferons in gastrointestinal injury repair. Nat Commun. 2021;12:2624 pubmed publisher
	Cao Q, Huang Q, Wang Y, Li C. Abraxane-induced bone marrow CD11b+ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with 64Cu-labeled anti-CD11b and prevented by anti-CSF-1. Theranostics. 2021;11:3527-3539 pubmed publisher
	Etzerodt A, Moulin M, Doktor T, Delfini M, Mossadegh Keller N, Bajenoff M, et al. Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer. J Exp Med. 2020;217: pubmed publisher
	Etzerodt A, Tsalkitzi K, Maniecki M, Damsky W, Delfini M, Baudoin E, et al. Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression. J Exp Med. 2019;216:2394-2411 pubmed publisher
	Schott E, Farnsworth C, Grier A, Lillis J, Soniwala S, Dadourian G, et al. Targeting the gut microbiome to treat the osteoarthritis of obesity. JCI Insight. 2018;3: pubmed publisher
	Svedova J, Menoret A, Mittal P, Ryan J, Buturla J, Vella A. Therapeutic blockade of CD54 attenuates pulmonary barrier damage in T cell-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2017;313:L177-L191 pubmed publisher
	Kawasaki N, VELA J, Nycholat C, Rademacher C, Khurana A, Van Rooijen N, et al. Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. Proc Natl Acad Sci U S A. 2013;110:7826-31 pubmed publisher
	Klaas M, Oetke C, Lewis L, Erwig L, Heikema A, Easton A, et al. Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni. J Immunol. 2012;189:2414-22 pubmed publisher
	Wu C, Rauch U, Korpos E, Song J, Loser K, Crocker P, et al. Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression. J Immunol. 2009;182:6508-16 pubmed publisher
	Oetke C, Vinson M, Jones C, Crocker P. Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels. Mol Cell Biol. 2006;26:1549-57 pubmed
	Crocker P, Freeman S, Gordon S, Kelm S. Sialoadhesin binds preferentially to cells of the granulocytic lineage. J Clin Invest. 1995;95:635-43 pubmed

product information

Product Type :

Antibody

Product Name :

CD169 (Siglec-1) Monoclonal Antibody (SER-4), eFluor™ 660, eBioscience

Catalog # :

50-5755-80

Quantity :

25 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse

Clone :

SER-4

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

Cd169; dJ1009E24.1; macrophage receptor; p210; pSn; SA; SER; sheep erythrocyte receptor; sialic acid binding Ig like lectin 1; sialic acid binding Ig-like lectin 1, sialoadhesin; Sialic acid-binding Ig-like lectin 1; sialic acid-binding immunoglobulin-like lectin 1; sialoadhesin; SIGLEC1; Siglec-1; SN

more info or order :

Invitrogen product webpage